Joan C. Han
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View article: MON-670 Pituitary Expression of Brain-Derived Neurotrophic Factor (BDNF) and Projection of Hypothalamic BDNF-expressing Neurons
MON-670 Pituitary Expression of Brain-Derived Neurotrophic Factor (BDNF) and Projection of Hypothalamic BDNF-expressing Neurons Open
Disclosure: E.C. Tsao: None. A.F. Zhao: None. J.C. Han: None. C.E. Kinney: None. Objectives: Brain-derived neurotrophic factor (BDNF) plays important roles in embryologic development of the central nervous system and postnatally functions …
View article: SUN-403 Apparent Mineralocorticoid Excess (AME): Challenges in the Newborn Period
SUN-403 Apparent Mineralocorticoid Excess (AME): Challenges in the Newborn Period Open
Disclosure: S. Patel: None. L. Choleva: None. M. Wilkes: None. C.J. Romero: None. B.C. Shah: None. R. Rapaport: None. J.C. Han: None. M. Yau: None. Classic apparent mineralocorticoid excess (AME) is a rare form of low renin hypertension. I…
View article: MON-249 Higher Physical Activity Level is Associated with Skeletal Muscle Mass Preservation after Bariatric Surgery in Adolescents with Obesity
MON-249 Higher Physical Activity Level is Associated with Skeletal Muscle Mass Preservation after Bariatric Surgery in Adolescents with Obesity Open
Disclosure: S.B. Zakashansky: None. V.H. Jonokuchi: None. A.F. Zhao: None. J.C. Han: None. Background: Reduction of skeletal muscle mass (SMM) is commonly observed after bariatric surgery in both adults and adolescents. This unfavorable ef…
View article: Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis
Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis Open
Summary Background and Objectives Resting energy expenditure (REE) assessments can help inform clinical treatment decisions in adolescents with elevated body mass index (BMI), but current equations are suboptimal for severe obesity. We dev…
View article: PB1410 The Association between Microvascular Health and Coagulation Parameters: The Netherlands Epidemiology of Obesity Study
PB1410 The Association between Microvascular Health and Coagulation Parameters: The Netherlands Epidemiology of Obesity Study Open
View article: Dissociative identity precipitated by emergence from general anesthesia: A case report and analytical framework
Dissociative identity precipitated by emergence from general anesthesia: A case report and analytical framework Open
View article: Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue
Chronic intake of high dietary sucrose induces sexually dimorphic metabolic adaptations in mouse liver and adipose tissue Open
View article: Prenatal metabolomic profiles mediate the effect of maternal obesity on early childhood growth trajectories and obesity risk: the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study
Prenatal metabolomic profiles mediate the effect of maternal obesity on early childhood growth trajectories and obesity risk: the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study Open
View article: Pharmacologic Weight Management in the Era of Adolescent Obesity
Pharmacologic Weight Management in the Era of Adolescent Obesity Open
Context Pediatric obesity is a serious health problem in the United States. While lifestyle modification therapy with dietary changes and increased physical activity are integral for the prevention and treatment of mild to moderate obesity…
View article: Acceptability of Time-Limited Eating in Pediatric Weight Management
Acceptability of Time-Limited Eating in Pediatric Weight Management Open
Background Adherence to dietary interventions is a significant barrier in the treatment of childhood obesity. Time-limited eating (TLE) is a simple dietary approach that limits food intake to a given number of consecutive hours per day, bu…
View article: Energy expenditure deficits drive obesity in a mouse model of Alström syndrome
Energy expenditure deficits drive obesity in a mouse model of Alström syndrome Open
Alström syndrome (AS) is a rare multi-system disorder for which early-onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss-of-function mutations develop obesity, supporting the notion that ALMS1…
View article: Review of Insulin Resistance in Dilated Cardiomyopathy and Implications for the Pediatric Patient Short Title: Insulin Resistance DCM and Pediatrics
Review of Insulin Resistance in Dilated Cardiomyopathy and Implications for the Pediatric Patient Short Title: Insulin Resistance DCM and Pediatrics Open
Energy metabolism in the heart is affected during states of dysfunction. Understanding how the heart utilizes substrates in cardiomyopathy may be key to the development of alternative treatment modalities. Myocardial insulin resistance has…
View article: Waitlist management in a pediatric weight management clinic: implementing an orientation session
Waitlist management in a pediatric weight management clinic: implementing an orientation session Open
Background This study evaluates implementation of an orientation session to address a waitlist of more than 2000 referrals to a pediatric weight management clinic in the Mid-South United States. Methods An hour-long group-based orientation…
View article: The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder
The contribution of platelets to peripheral BDNF elevation in children with autism spectrum disorder Open
Brain-derived neurotrophic factor (BDNF), a key peptide in neurocognitive development, has been reported to be elevated in the serum of children with autism spectrum disorder (ASD). In a few studies, however, no differences or the converse…
View article: The efficacy and safety of setmelanotide in individuals with Bardet-Biedl syndrome or Alström syndrome: Phase 3 trial design
The efficacy and safety of setmelanotide in individuals with Bardet-Biedl syndrome or Alström syndrome: Phase 3 trial design Open
Study Design, Statistical Design, Study Protocols.
View article: A Phase 3 Trial in Participants With Obesity Due to Bardet-Biedl Syndrome or Alström Syndrome: Efficacy and Safety of the Melanocortin 4 Receptor Agonist Setmelanotide
A Phase 3 Trial in Participants With Obesity Due to Bardet-Biedl Syndrome or Alström Syndrome: Efficacy and Safety of the Melanocortin 4 Receptor Agonist Setmelanotide Open
Introduction: This randomized Phase 3 trial evaluated the effect of setmelanotide, a melanocortin 4 receptor agonist, on weight loss, hunger reduction, and safety outcomes in individuals (aged ≥6 years) with obesity and a genetically confi…
View article: Investigating Insulin Resistance in Pediatric Cardiomyopathy - A Pilot Study
Investigating Insulin Resistance in Pediatric Cardiomyopathy - A Pilot Study Open
Children with cardiomyopathy are a vulnerable population and understanding the factors that contribute to cardiac dysfunction are of great importance. At the biochemical level, energy utilization by cardiomyocytes during stress may provide…
View article: Associations of prenatal metabolomics profiles with early childhood growth trajectories and obesity risk in African Americans: the CANDLE study
Associations of prenatal metabolomics profiles with early childhood growth trajectories and obesity risk in African Americans: the CANDLE study Open
View article: The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet
The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet Open
View article: Author Correction: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Author Correction: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Consensus clinical management guidelines for Alström syndrome
Consensus clinical management guidelines for Alström syndrome Open
View article: Oxytocin for treating Prader-Willi Syndrome
Oxytocin for treating Prader-Willi Syndrome Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the clinical effects of oxytocin and potential adverse effects on the behavior and excessive eating in people with PWS.
View article: Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders Open
View article: The gut mycobiome of healthy mice is shaped by the environment and shapes metabolic outcomes in response to diet
The gut mycobiome of healthy mice is shaped by the environment and shapes metabolic outcomes in response to diet Open
Objective As an active interface between the host and their diet, the gut bacteriome influences host metabolic adaptation. However, the contribution of gut fungi to host metabolic outcomes is not yet understood. Therefore, we aimed to dete…
View article: Chronic high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue
Chronic high dietary sucrose induces sexually dimorphic metabolic adaptations in liver and adipose tissue Open
Summary Almost all effective treatments for non-alcoholic fatty liver disease (NAFLD) involve reduction of adiposity, which suggests the metabolic axis between liver and adipose tissue is essential to NAFLD development. Since excessive die…
View article: SUN-036 Evaluation of Gender Experience Among Individuals with Isolated GnRH Deficiency Compared to Controls
SUN-036 Evaluation of Gender Experience Among Individuals with Isolated GnRH Deficiency Compared to Controls Open
Background: Sex hormones play a role in gender identity development. For example, 46,XY individuals with complete androgen insensitivity typically have a female gender identity. Isolated GnRH deficiency (IGD) leads to hypogonadism due to d…
View article: Effects of Maternal Dietary Patterns during Pregnancy on Early Childhood Growth Trajectories and Obesity Risk: The CANDLE Study
Effects of Maternal Dietary Patterns during Pregnancy on Early Childhood Growth Trajectories and Obesity Risk: The CANDLE Study Open
We investigated the associations between maternal dietary patterns during pregnancy and early childhood growth trajectories and overweight/obesity risk in offspring. Maternal diet was assessed using a food frequency questionnaire during th…
View article: In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene
In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene Open
View article: BridgesLab/TissueSpecificTscKnockouts: bioRxiv Submission
BridgesLab/TissueSpecificTscKnockouts: bioRxiv Submission Open
This is the dataset for the TSC knockout repository, including manuscript files and all underlying data at the time of initial submission to bioRxiv and Molecular Metabolism. The preprint of this manuscript can be found at: Stephenson EJ, …
View article: Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice
Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice Open
The mechanistic target of rapamycin (mTORC1) is a nutrient responsive protein kinase complex that helps co-ordinate anabolic processes across all tissues. There is evidence that signaling through mTORC1 in skeletal muscle may be a determin…