Joan Jiménez-Baladó
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View article: CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital-Based Neurology Cohort
CSF Biomarker Profile of Cerebral Amyloid Angiopathy: Diagnostic Performance and Imaging Correlates in a Hospital-Based Neurology Cohort Open
BACKGROUND Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer’s disease (AD), which complicates diagnosis in patients with cognitive impairment. The cerebrospinal fluid (CSF) biomarker profile of CAA, particularly in the…
View article: Long-term Stroke Recurrence in Atrial Fibrillation: Differential Predictors of Ischaemic and Haemorrhagic Risk
Long-term Stroke Recurrence in Atrial Fibrillation: Differential Predictors of Ischaemic and Haemorrhagic Risk Open
Background Predictors of long-term ischaemic and haemorrhagic stroke recurrence (LTSR) after acute ischaemic stroke (AIS) with AF remain uncertain. This study aimed to identify independent predictors of LTSR in patients with AF-related AIS…
View article: Biological age acceleration is more prevalent in men than in women at time of spontaneous intracerebral hemorrhage
Biological age acceleration is more prevalent in men than in women at time of spontaneous intracerebral hemorrhage Open
Objective Spontaneous intracerebral hemorrhage (ICH) occurs later in life in women compared to men. Although previous studies have demonstrated epigenetic age acceleration (EAA) differences in ischemic stroke (IS) patients - a measure of a…
View article: The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol
The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol Open
Background Spontaneous, non-traumatic intracranial hemorrhage (ICH) is highly heritable disease. However, the identification of the genetic risk factors driving this high genetic predisposition has been limited by small sample sizes and un…
View article: Patent foramen ovale diagnosis in young stroke patients: analysis of recurrence and mortality
Patent foramen ovale diagnosis in young stroke patients: analysis of recurrence and mortality Open
Background Revised European Stroke Organization guidelines in 2018 recommend early patent foramen ovale (PFO) detection and closure in patients aged 60 or younger who suffered an ischemic stroke. Our primary aim was to analyze the impact o…
View article: Epigenetic age and long-term cancer risk following a stroke
Epigenetic age and long-term cancer risk following a stroke Open
Our findings suggest that epigenetic accelerated aging, as indicated by Hannum's EEAA, may play a significant role in the increased cancer risk observed in CVE survivors.
View article: Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus
Acute-to-chronic glycemic ratio as an outcome predictor in ischemic stroke in patients with and without diabetes mellitus Open
Objective Elevated plasma glucose levels are common in patients suffering acute ischemic stroke (AIS), and acute hyperglycemia has been defined as an independent determinant of adverse outcomes. The impact of acute-to-chronic glycemic rati…
View article: DNA methylation and stroke prognosis: an epigenome-wide association study
DNA methylation and stroke prognosis: an epigenome-wide association study Open
View article: Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Blood DNA Methylation Analysis Reveals a Distinctive Epigenetic Signature of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Open
View article: The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review
The Role of Epigenetics in Brain Aneurysm and Subarachnoid Hemorrhage: A Comprehensive Review Open
This comprehensive review explores the emerging field of epigenetics in intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (aSAH). Despite recent advancements, the high mortality of aSAH needs an understanding of its underly…
View article: Blood‐brain barrier permeability and risk of conversion to dementia in patients with mild cognitive impairment
Blood‐brain barrier permeability and risk of conversion to dementia in patients with mild cognitive impairment Open
Background Cardiovascular risk factors (CVRF) have been associated with an increased risk of cognitive decline and dementia. Increase of blood‐brain barrier permeability (BBBp) measured by CSF/serum albumin ratio (Qalb) have been associate…
View article: Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review.
Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review. Open
Blood biomarkers represent a promising future for studying cognitive impairment, particularly in Alzheimer's Disease (AD), as they offer a non-invasive alternative to cerebrospinal fluid tests and have potential as population screenin…
View article: Risk of cognitive decline progression is associated to increased blood‐brain‐barrier permeability: A longitudinal study in a memory unit clinical cohort
Risk of cognitive decline progression is associated to increased blood‐brain‐barrier permeability: A longitudinal study in a memory unit clinical cohort Open
INTRODUCTION This study examined the relationship between blood‐brain‐barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb), and cognitive decline progression in a clinical cohort. METHODS This prospective…
View article: Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age
Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age Open
In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methyla…
View article: Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage
Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage Open
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lob…
View article: Migraine Aura mimicking Stroke in Code Stroke. Analysis of diagnostic prediction models.
Migraine Aura mimicking Stroke in Code Stroke. Analysis of diagnostic prediction models. Open
Background: Differences between migraine with aura (MA) mimicking stroke and ischemic strokes were analyzed to create a predictive diagnostic model.Methods: Prospective cohort of code strokes attended between January 2005 and June 2020 in …
View article: Reduced Hippocampal GABA+ Is Associated With Poorer Episodic Memory in Healthy Older Women: A Pilot Study
Reduced Hippocampal GABA+ Is Associated With Poorer Episodic Memory in Healthy Older Women: A Pilot Study Open
Background : The current pilot study was designed to examine the association between hippocampal γ-aminobutyric acid (GABA) concentration and episodic memory in older individuals, as well as the impact of two major risk factors for Alzheim…
View article: New candidate blood biomarkers potentially associated with white matter hyperintensities progression
New candidate blood biomarkers potentially associated with white matter hyperintensities progression Open
View article: Diabetes, Albuminuria and the Kidney—Brain Axis
Diabetes, Albuminuria and the Kidney—Brain Axis Open
Cognitive decline and kidney disease are significant public health problems that share similar characteristics and risk factors. The pathophysiology of the kidney–brain axis is not completely understood, and studies analysing the relations…
View article: Genome-wide Transcriptome Study in Skin Biopsies Reveals an Association of E2F4 With Cadasil and Cognitive Impairment
Genome-wide Transcriptome Study in Skin Biopsies Reveals an Association of E2F4 With Cadasil and Cognitive Impairment Open
Background:CADASIL is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the receptor, causing protein misfolding and aggregation. The main symptoms are migraine, psychiatric disturbances, recur…
View article: Cognitive Impact of Cerebral Small Vessel Disease Changes in Patients With Hypertension
Cognitive Impact of Cerebral Small Vessel Disease Changes in Patients With Hypertension Open
Hypertension is one of the principal risk factors for cerebral small vessel disease progression and cognitive impairment. We aimed to investigate how changes in cerebral small vessel disease lesions relate to cognitive decline and incident…