Explanipedia

Nanoengineered innovations on DNA delivery systems for targeted cancer therapy Open

Renato Nunes, Joana F. A. Valente, Tatiana Patrício, Ângela Sousa · 2025

Innovative Minicircle DNA Vector Encoding pri-miR-375 Silences E6 and E7 oncoproteins in HPV16-positive CaSki Cells Open

Diego Pereira, Ana M. Almeida, João A. Queiroz, Fani Sousa, Nuno Alves , et al. · 2025

Ocean acidification will not affect the shell strength of juveniles of the commercial clam species Chamelea gallina: Implications of the local alkalinization of seawater Open

Laura Sordo, Esteves Eduardo, Joana F. A. Valente, Jaime Aníbal, Catarina M.M. Duarte , et al. · 2024

Ocean acidification (OA) is expected to decrease the strength of bivalves' shells, especially during the early stages of development, with negative consequences to the resilience of natural populations and the economy. The objectives of th…

Metal-based approaches to fight cervical cancer Open

Diana Pereira, Nuno Alves, Ângela Sousa, Joana F. A. Valente · 2024

Cervical cancer (CC) is one of the leading causes of death among women worldwide. The current treatments for this cancer consist of invasive methods such as chemotherapeutic drugs, radiation, immunotherapy and surgery, which could lead to …

Silver and Antimicrobial Polymer Nanocomplexes to Enhance Biocidal Effects Open

Diana Pereira, Susana Ferreira, Gloria B. Ramírez‐Rodríguez, Nuno Alves, Ângela Sousa , et al. · 2024

Antimicrobial resistance has become a major problem over the years and threatens to remain in the future, at least until a solution is found. Silver nanoparticles (Ag-NPs) and antimicrobial polymers (APs) are known for their antimicrobial …

Assessment of 3D-Printed Polycaprolactone, Hydroxyapatite Nanoparticles and Diacrylate Poly(ethylene glycol) Scaffolds for Bone Regeneration Open

Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes , et al. · 2022

Notwithstanding the advances achieved in the last decades in the field of synthetic bone substitutes, the development of biodegradable 3D-printed scaffolds with ideal mechanical and biological properties remains an unattained challenge. In…

Editorial for Special Issue: “Additive Manufacturing Approaches to Produce Drug Delivery Systems” Open

Joana F. A. Valente, Nuno Alves · 2022

Cutting-edge technologies such as additive manufacturing (AM) have had an enormous impact in a multitude of sectors [...]

Assessment Of 3D Printed Polycaprolactone, Hydroxyapatite Nanoparticles and Polyethylene Glycol Diacrylate Scaffolds for Bone Regeneration Open

Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes , et al. · 2022

Notwithstanding the advances achieved in the last decades in the field of synthetic bone substitutes, the development of biodegradable 3D scaffolds with ideal mechanical and biological properties remains an unattained challenge. In this wo…

Arginine-Modified 3D-Printed Chromatographic Supports Open

Joana F. A. Valente, Tiago Soares Carreira, Juliana R. Dias, Fani Sousa, Nuno Alves · 2022

The increasing progression of biopharmaceutical-based therapies highlights the demand for efficient chromatographic methods that can be used to purify the desired biomolecules (e.g., nucleic acids, enzymes, or monoclonal antibodies) which …

Electrospun-Based Membranes as a Key Tool to Prevent Respiratory Infections Open

Sara F. C. Guerreiro, Carolina A. M. Ferreira, Joana F. A. Valente, Tatiana Patrício, Nuno Alves , et al. · 2022

The use of electrospun meshes has been proposed as highly efficient protective equipment to prevent respiratory infections. Those infections can result from the activity of micro-organisms and other small dust particles, such as those resu…

Advanced Face Mask Filters Based on PCL Electrospun Meshes Dopped with Antimicrobial MgO and CuO Nanoparticles Open

Carolina A. M. Ferreira, Sara F. C. Guerreiro, Joana F. A. Valente, Tatiana Patrício, Nuno Alves , et al. · 2022

The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL…

Chitosan–Silver Nanoconjugates to Achieve Enhanced Antimicrobial Effect and Fight Cervical Cancer Open

Diana Pereira, Susana Ferreira, Nuno Alves, Ângela Sousa, Joana F. A. Valente · 2022

Cervical cancer (CC) is considered to be the fourth most frequently diagnosed cancer worldwide and the second leading cause of cancer deaths in women, causing about 10 premature deaths per week in women in the age group 20–39 years [...]

3D Printing for Affinity Chromatographic Support Production Open

Joana F. A. Valente, Juliana R. Dias, Fani Sousa, Nuno Alves · 2022

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract 3D Printing for Affinity Chromatographic Support Production † by Joana …

Polymeric Blends with Copper: A Powerful Weapon against Pathogenic Spread Open

Cyril Santos, Hugo Marques, Artur Mateus, Nuno Alves, Joana F. A. Valente · 2022

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Polymeric Blends with Copper: A Powerful Weapon against Pathogenic Spre…

Production, Characterisation, and In Vitro Evaluation of 3D Printed PCL/HANp/PEGDA Scaffold for Bone Regeneration Open

Ana Catarina Sousa, Sara Biscaia, Rui Alvites, Mariana Branquinho, Bruna Lopes , et al. · 2022

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract Production, Characterisation, and In Vitro Evaluation of 3D Printed PCL…

New Combined Approach to Simplify the Minicircular DNA Lysate and Directly Apply in Ion Exchange Membrane Chromatography Open

Daniela Carvalho, Diana Pereira, Nuno Alves, Andreas Pickl, Sara Cardoso , et al. · 2022

first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract New Combined Approach to Simplify the Minicircular DNA Lysate and Direc…

Dopamine-Coated Silver Nanoparticles: Therapeutic Agents to Fight Bacteria and Fungi Open

Diana Pereira, Susana Ferreira, Nuno Alves, Ângela Sousa, Joana F. A. Valente · 2022

Open AccessAbstract Dopamine-Coated Silver Nanoparticles: Therapeutic Agents to Fight Bacteria and Fungi † by Diana Pereira 1,*, Susana Ferreira 1, Nuno Alves 2, Ângela Sousa 1 and Joana F. A. Valente 2,* 1 CICS-UBI—Centro de Investigação …

Metallic Structures: Effective Agents to Fight Pathogenic Microorganisms Open

Diana Pereira, Tiago Soares Carreira, Nuno Alves, Ângela Sousa, Joana F. A. Valente · 2022

The current worldwide pandemic caused by coronavirus disease 2019 (COVID-19) had alerted the population to the risk that small microorganisms can create for humankind’s wellbeing and survival. All of us have been affected, directly or indi…

Additive Manufacturing Tools to Improve the Performance of Chromatographic Approaches Open

Joana F. A. Valente, Fani Sousa, Nuno Alves · 2021

Effect of Plasmid DNA Size on Chitosan or Polyethyleneimine Polyplexes Formulation Open

Joana F. A. Valente, Patrícia Pereira, Ângela Sousa, João A. Queiroz, Fani Sousa · 2021

Gene therapy could be simply defined as a strategy for the introduction of a functional copy of desired genes in patients, to correct some specific mutation and potentially treat the respective disorder. However, this straightforward defin…

Box‐Behnken Design a Key Tool to Achieve Optimized PCL/Gelatin Electrospun Mesh Open

Sara F. C. Guerreiro, Joana F. A. Valente, Juliana R. Dias, Nuno Alves · 2021

Hybrid electrospun nanofibers of polycaprolactone (PCL)/gelatin are considered as drug‐delivery systems for increasing the treatment efficacy in superficial (skin) wounds. Continuous delivery of therapeutic agents, skin extracellular matri…

Effect of Chromatographic Conditions on Supercoiled Plasmid DNA Stability and Bioactivity Open

G.M. Azevedo, Joana F. A. Valente, Ângela Sousa, Augusto Q. Pedro, Patrícia Pereira , et al. · 2019

The dysfunction of the tumor suppressor gene TP53 has been associated with the pathogenesis of the majority of the cases of cancer reported to date, leading the cell to acquire different features known as the cancer hallmarks. In normal si…

Composite Central Face Design—An Approach to Achieve Efficient Alginate Microcarriers Open

Joana F. A. Valente, Juliana R. Dias, Ângela Sousa, Nuno Alves · 2019

Microparticulated drug delivery systems have been used as promising encapsulation systems for protecting drugs for in vitro and in vivo applications, enhancing its stability, providing an increased surface to volume ratio, reducing adverse…

DoE to improve supercoiled p53-pDNA purification by O-phospho-l-tyrosine chromatography Open

Joana F. A. Valente, Ângela Sousa, João A. Queiroz, Fani Sousa · 2019

DoE to improve supercoiled p53-pDNA purification by O-phospho-l-tyrosine chromatography Open

Joana F. A. Valente, Ângela Sousa, João A. Queiroz, Fani Sousa · 2018

Affinity purification and delivery of a p53-encoding plasmid DNA for gene mediated cancer therapy Open

Joana F. A. Valente · 2018

Cancer is still one of the leading causes of death worldwide. In order to treat this scourge, gene therapy and DNA vaccination have been proposed as an alternative to the common treatments. Among the several gene abnormalities that could b…

The biological performance of purified supercoiled p53 plasmid DNA in different cancer cell lines Open

Joana F. A. Valente, Ângela Sousa, Vítor M. Gaspar, João A. Queiroz, Fani Sousa · 2018

Serviço Psicopedagógico de Promoção de Habilidades Cognitivas em Atletas de Competição: SPAC Open

Joana F. A. Valente, Luís André · 2017

As habilidades necessárias para um atleta para ter sucesso no desporto de alta competição são plurais. Vários estudos têm considerado que o desempenho de um atleta resulta da interação entre as habilidades físicas, motoras, técnico-táticas…

Affinity analysis and application of dipeptides derived from l-tyrosine in plasmid purification Open

Soraia Ferreira, Josué Carvalho, Joana F. A. Valente, Marta C. Corvo, Eurico J. Cabrita , et al. · 2015

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