José L. F. C. Lima
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View article: Mixture Design and Doehlert Matrix for Optimization of Energized Dispersive Guided Extraction (EDGE) of Theobromine and Caffeine from Cocoa Bean Shells
Mixture Design and Doehlert Matrix for Optimization of Energized Dispersive Guided Extraction (EDGE) of Theobromine and Caffeine from Cocoa Bean Shells Open
This work describes the development of a method for the extraction of methylxanthines from cocoa bean shell (CBS) by employing the novel Energized Dispersive Guided Extraction (EDGE) system. The mixtures were composed of ethanol–methanol–w…
View article: Intense Pulsed Light (IPL) from Dermatology to Ophthalmology
Intense Pulsed Light (IPL) from Dermatology to Ophthalmology Open
Intense pulsed light (IPL) are medical-esthetical procedures that emit light at a wavelength of 500 – 1200 nm, interacting with epidermal and dermal tissues. IPL is a relatively new treatment of growing popularity thanks to its versatility…
View article: Arqueologia marítima em Cabo Verde: enquadramento e primeiros resultados do projecto CONCHA
Arqueologia marítima em Cabo Verde: enquadramento e primeiros resultados do projecto CONCHA Open
Among the partners of the UNESCO Chair The Ocean’s Cultural Heritage are CHAM and IPC (Cape Verde) which defined as essential action the underwater archaeological site inventory of that archipelago. This action started in 2018 as part of t…
View article: Evaluation of NSAIDs antioxidant activity on lipid peroxidation in splenocyte membranes
Evaluation of NSAIDs antioxidant activity on lipid peroxidation in splenocyte membranes Open
Here we summarized the nanoscale layered transition metal chalcogenide superconductors, mainly based on the experimental results. In transition-metal chalcogenides the interplay between strong electron-electron and electron-phonon interact…
View article: Screening of fluoroquinolones in environmental waters using disk-based solid-phase extraction combined to microplate fluorimetric determination and LC-MS/MS
Screening of fluoroquinolones in environmental waters using disk-based solid-phase extraction combined to microplate fluorimetric determination and LC-MS/MS Open
Fluoroquinolones are in the order of the day concerning environmental contamination through anthropogenic activities, resulting in increased risk for antibiotic resistance dissemination. In this context, accessible, low-cost analytical met…
View article: Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood
Optimization of Experimental Settings for the Assessment of Reactive Oxygen Species Production by Human Blood Open
The purpose of an experimental design is to improve the productivity of experimentation. It is an efficient procedure for planning experiments, so the data obtained can be analyzed to yield a valid and objective conclusion. This approach h…
View article: Professor José Luís Costa Lima, with an extensive and prestigious academic career, collaborated and continues to collaborate with many Brazilian research groups
Professor José Luís Costa Lima, with an extensive and prestigious academic career, collaborated and continues to collaborate with many Brazilian research groups Open
where he also obtained a PhD degree with a thesis titled "Ion-selective electrodes with conductive resin support".In 1986, he joined the Faculty of Pharmacy of the University of Porto (FFUP) as an assistant professor and participated in th…
View article: Calcium Pathways in Human Neutrophils—The Extended Effects of Thapsigargin and ML-9
Calcium Pathways in Human Neutrophils—The Extended Effects of Thapsigargin and ML-9 Open
In neutrophils, intracellular Ca2+ levels are regulated by several transporters and pathways, namely SERCA [sarco(endo)plasmic reticulum Ca2+-ATPase], SOCE (store-operated calcium entry), and ROCE (receptor-operated calcium entry). However…
View article: A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity
A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity Open
Daunorubicin is extensively used in chemotherapy for diverse types of cancer. Over the years, evidence has suggested that the mechanisms by which daunorubicin causes cytotoxic effects are also associated with interactions at the membrane l…
View article: Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies
Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies Open
Despite doxorubicin being commonly used in chemotherapy there still remain significant holes in our knowledge regarding its delivery efficacy and an observed resistance mechanism that is postulated to involve the cell membrane. One possibl…
View article: An eco-friendly method for analysis of sulfonamides in water samples using a multi-pumping system
An eco-friendly method for analysis of sulfonamides in water samples using a multi-pumping system Open
A new methodology for determination of sulfonamides (sulfaquinoxaline, sulfathiazole, and sulfadimethoxine) in water samples was developed by coupling an automated multi-pumping flow system (MPFS) with a liquid waveguide capillary cell (LW…
View article: Fluoroquinolones and sulfonamides: features of their determination in water. A review
Fluoroquinolones and sulfonamides: features of their determination in water. A review Open
Sulfonamides and fluoroquinolones are two group of antibiotics widely used in the treatment of bacterial infections. Monitoring these residues in live animals and animal products is commonly legislated; however, the environmental occurrenc…