Joana N. Bugalhão
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View article: <scp>LZTS2</scp> Negatively Regulates Centrosomal <scp>CEP135</scp> Levels and Microtubule Nucleation
<span>LZTS2</span> Negatively Regulates Centrosomal <span>CEP135</span> Levels and Microtubule Nucleation Open
The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instabi…
View article: The Chlamydia trachomatis IncM Protein Interferes with Host Cell Cytokinesis, Centrosome Positioning, and Golgi Distribution and Contributes to the Stability of the Pathogen-Containing Vacuole
The Chlamydia trachomatis IncM Protein Interferes with Host Cell Cytokinesis, Centrosome Positioning, and Golgi Distribution and Contributes to the Stability of the Pathogen-Containing Vacuole Open
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes ocular and urogenital infections in humans. The ability of C. trachomatis to grow intracellularly in a pathogen-containing vacuole (known as an inclusion) de…
View article: The Chlamydia trachomatis inclusion membrane protein CT006 associates with lipid droplets in eukaryotic cells
The Chlamydia trachomatis inclusion membrane protein CT006 associates with lipid droplets in eukaryotic cells Open
Chlamydia trachomatis causes genital and ocular infections in humans. This bacterial pathogen multiplies exclusively within host cells in a characteristic vacuole (inclusion) and delivers proteins such as inclusion membrane proteins (Incs)…
View article: The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg
The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg Open
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and mul…
View article: The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion
The Chlamydia trachomatis type III secretion substrates CT142, CT143, and CT144 are secreted into the lumen of the inclusion Open
Chlamydia trachomatis is a human bacterial pathogen causing ocular and genital infections. It multiplies exclusively within an intracellular membrane-bound vacuole, the inclusion, and uses a type III secretion system to manipulate h…
View article: Identification of regions within the <i>Legionella pneumophila</i> VipA effector protein involved in actin binding and polymerization and in interference with eukaryotic organelle trafficking
Identification of regions within the <i>Legionella pneumophila</i> VipA effector protein involved in actin binding and polymerization and in interference with eukaryotic organelle trafficking Open
The Legionella pneumophila effector protein VipA is an actin nucleator that co‐localizes with actin filaments and early endosomes in infected macrophages and which interferes with organelle trafficking when expressed in yeast. To identify …
View article: Bacterial nucleators: actin' on actin
Bacterial nucleators: actin' on actin Open
The actin cytoskeleton is a key target of numerous microbial pathogens, including protozoa, fungi, bacteria and viruses. In particular, bacterial pathogens produce and deliver virulence effector proteins that hijack actin dynamics to enabl…