Joana Pissarra
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View article: Portal hypertension in alcohol-associated hepatitis: harmless and the reflection of systemic inflammation?
Portal hypertension in alcohol-associated hepatitis: harmless and the reflection of systemic inflammation? Open
In our study, severe PH had no impact on 6-month TFS. Further investigations on the prognostic value of PH and its natural history in AH are warranted.
View article: Systematic screening for primary immunodeficiencies in patients hospitalized for severe infection in pediatric intensive care unit
Systematic screening for primary immunodeficiencies in patients hospitalized for severe infection in pediatric intensive care unit Open
Over 500 primary immunodeficiency diseases (PID) have been described, but immunological assessment after a severe infection is not routine. We aimed to evaluate the feasibility of a PID screening protocol and calculate PID prevalence in ch…
View article: Structural and Functional Characterization of the 28 <scp>kDa</scp> Structured Core of <scp>BmSA1</scp> , the Major Surface Antigen of <i>Babesia Microti</i>
Structural and Functional Characterization of the 28 <span>kDa</span> Structured Core of <span>BmSA1</span> , the Major Surface Antigen of <i>Babesia Microti</i> Open
Babesiosis is a tick‐borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human‐to‐human transmission through blood transfusion have made babesiosis an emerging disease in hu…
View article: Healthcare Resource Utilisation and Costs of Mepolizumab Initiation: A 5‐Year National Cohort Analysis
Healthcare Resource Utilisation and Costs of Mepolizumab Initiation: A 5‐Year National Cohort Analysis Open
International audience
View article: Prevalence of psychiatric disorders during pregnancy—a feasibility study at second trimester ultrasound in the general population (GROUP study): study protocol
Prevalence of psychiatric disorders during pregnancy—a feasibility study at second trimester ultrasound in the general population (GROUP study): study protocol Open
Introduction During the perinatal period, women have an increased risk for psychiatric disorders, which are highly prevalent in this context. In addition, there are significant delays in diagnosing these conditions, worsening their prognos…
View article: Influence of meteorological changes on the occurrence of cerebral aneurysm rupture in the Montpellier region: A retrospective study
Influence of meteorological changes on the occurrence of cerebral aneurysm rupture in the Montpellier region: A retrospective study Open
Due to the low accuracy of the statistical model, our study could not provide evidence of a link between weather variables and occurrence of aSAH. This issue requires further investigation and reliable epidemiological data to fully underst…
View article: Identifying innovations produced by primary health care centers and evaluating their scalability: the SPRINT Occitanie cross-sectional study in France
Identifying innovations produced by primary health care centers and evaluating their scalability: the SPRINT Occitanie cross-sectional study in France Open
Background Practice-based research is one of the levers identified by the World Health Organization (WHO) to strengthen primary health care. The scaling of health and social care innovations has the potential to reduce inequities in health…
View article: Hospitalizations for Chronic Obstructive Pulmonary Disease Exacerbation During COVID-19
Hospitalizations for Chronic Obstructive Pulmonary Disease Exacerbation During COVID-19 Open
This cross-sectional study investigates changes in the number of chronic obstructive pulmonary disease (COPD)–related admissions before, during, and after the COVID-19 pandemic in France.
View article: Identifying innovations produced by primary health care centers and evaluating their scalability: the SPRINT Occitanie cross-sectional study in France
Identifying innovations produced by primary health care centers and evaluating their scalability: the SPRINT Occitanie cross-sectional study in France Open
Background: Practice-based research is one of the levers identified by the World Health Organization (WHO) to strengthen primary health care. The scaling of health and social care innovations has thepotential to reduce inequities in health…
View article: A systematic review of peptide-based serological tests for the diagnosis of leishmaniasis
A systematic review of peptide-based serological tests for the diagnosis of leishmaniasis Open
Serological methods should meet the needs of leishmaniasis diagnosis due to their high sensitivity and specificity, economical and adaptable rapid diagnostic test format, and ease of use. Currently, the performances of serological diagnost…
View article: SILVI, an open-source pipeline for T-cell epitope selection
SILVI, an open-source pipeline for T-cell epitope selection Open
High-throughput screening of available genomic data and identification of potential antigenic candidates have promoted the development of epitope-based vaccines and therapeutics. Several immunoinformatic tools are available to predict pote…
View article: Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae
Combining High-Pressure NMR and Geometrical Sampling to Obtain a Full Topological Description of Protein Folding Landscapes: Application to the Folding of Two MAX Effectors from Magnaporthe oryzae Open
Despite advances in experimental and computational methods, the mechanisms by which an unstructured polypeptide chain regains its unique three-dimensional structure remains one of the main puzzling questions in biology. Single-molecule tec…
View article: Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process
Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process Open
Quality control pathways that oversee the quality of stable RNA molecules are critical for the cell. In this work, we demonstrate, for the first time, a functional link between Hfq and RNase R in the processing and degradation of the highl…
View article: Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?
Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages? Open
Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in…
View article: Inhibition of Plasmodium Liver Infection by Ivermectin
Inhibition of Plasmodium Liver Infection by Ivermectin Open
Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro . Notably, ivermectin p…
View article: Escaping Deleterious Immune Response in Their Hosts: Lessons from Trypanosomatids
Escaping Deleterious Immune Response in Their Hosts: Lessons from Trypanosomatids Open
The Trypanosomatidae family includes the genera Trypanosoma and Leishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. Trypanosoma brucei gambiense, Trypanosoma cruzi, and…