Joana Teixeira
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View article: A short 3’UTR motif regulates gene expression in bilaterians
A short 3’UTR motif regulates gene expression in bilaterians Open
The mechanisms of gene expression regulation are essential for cell identity and function, and their disruption usually leads to human disease. The 3’ untranslated region (UTR) of mRNA contains important regulatory elements of gene express…
View article: FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1
FOXM1 expression reverts aging chromatin profiles through repression of the senescence-associated pioneer factor AP-1 Open
Aging is characterized by changes in gene expression that drive deleterious cellular phenotypes leading to senescence. The transcriptional activation of senescence genes has been mainly attributed to epigenetic shifts, but the changes in c…
View article: The concept of motivation and its implication in additive disorders
The concept of motivation and its implication in additive disorders Open
Introduction The word motivation derives from the Latin movere, which means to move. In psychiatry, it is an isolated phenomenon found in the substrate of several pathologies, and may be part of an heterogeneous dimensional spectrum. Howev…
View article: Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers
Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers Open
Introductory paragraph The pancreas is a central organ for human diseases that have a dramatic societal burden, such as pancreatic cancer and diabetes 1,2 . Non-coding cis-regulatory elements (CREs) of DNA control gene expression 3,4 , bei…
View article: Evaluation of the Effectiveness of Acupuncture in the Treatment of Knee Osteoarthritis: A Case Study
Evaluation of the Effectiveness of Acupuncture in the Treatment of Knee Osteoarthritis: A Case Study Open
Background: Osteoarthritis is a widespread chronic disease seen as a continuum of clinical occurrences within several phases, which go from synovial inflammation and microscopic changes of bone and cartilage to painful destructive changes …
View article: A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal
A nationwide serosurvey of hepatitis E virus antibodies in the general population of Portugal Open
The present nation-wide survey provides insight in the epidemiology of HEV in Portugal and confirms that HEV is endemic in the Portuguese population.
View article: Quality of Life and aortobifemoral bypass – Importance of the hypogastric arteries
Quality of Life and aortobifemoral bypass – Importance of the hypogastric arteries Open
Aim: Evaluate SD after AFB and assess the importance of patent hypogastric arteries before the procedure. Introduction: The aortobifemoral bypass (AFB) is one of the best options to revascularize patients with Aortoiliac Occlusive Disease …