Johanna Lepeule
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View article: Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis
Road traffic noise exposure and blood DNA methylation at birth and in childhood: An epigenome-wide meta-analysis Open
Road traffic noise exposure has been associated with multiple adverse outcomes in epidemiological studies. However, the underlying biological mechanisms remain unclear. The aim of this study was to investigate the association between road …
View article: Effects of projected increases in heat exposure on linguistic development in two-year-old children: A longitudinal modified treatment policy analysis
Effects of projected increases in heat exposure on linguistic development in two-year-old children: A longitudinal modified treatment policy analysis Open
Background: Previous studies have demonstrated that in utero and early life heat exposure can influence neurodevelopment. However, to our knowledge, these investigations have not evaluated realistic counterfactual scenarios; instead, they …
View article: Effect of acute air pollution exposure on pregnant women's blood pressure: Insights from personal exposure assessment
Effect of acute air pollution exposure on pregnant women's blood pressure: Insights from personal exposure assessment Open
Background: Exposure to air pollution has been associated with adverse cardiovascular outcomes. Pregnant women may be especially vulnerable to air pollution due to physiological changes that affect blood pressure regulation. Traditional me…
View article: hdmax2, an R package to perform high dimension mediation analysis
hdmax2, an R package to perform high dimension mediation analysis Open
Mediation analysis plays a crucial role in epidemiology, unraveling the intricate pathways through which exposures exert influence on health outcomes. Recent advances in high-throughput sequencing techniques have generated growing interest…
View article: Perinatal air pollution exposure and autism spectrum disorder severity: The intertwined roles of green space, grey space and healthcare accessibility – A cohort study
Perinatal air pollution exposure and autism spectrum disorder severity: The intertwined roles of green space, grey space and healthcare accessibility – A cohort study Open
These findings highlight the critical role of healthcare accessibility and environmental factors in shaping the relationship between air pollution and ASD severity. Integrating geographic and environmental contexts is crucial when evaluati…
View article: Replacing cars with green spaces: an assessment of the mortality benefits in Paris
Replacing cars with green spaces: an assessment of the mortality benefits in Paris Open
Increasing urban vegetation coverage is associated with improved human health and well-being, reduced environmental impact of cities and enhanced urban resilience to climate change. To support evidence-based urban planning, this study quan…
View article: Environmental justice in France: Analysis of the association between exposure to environmental pollution and social deprivation
Environmental justice in France: Analysis of the association between exposure to environmental pollution and social deprivation Open
This study highlights the compounding effects of environmental and social inequities in France, underscoring the need for targeted interventions to reduce disparities in pollution exposure and associated health risks.
View article: Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight
Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight Open
This novel untargeted workflow elucidated biological mechanisms linking environmental exposures to child obesity, potentially supporting targeted public health interventions.
View article: Associations of family affluence with cortisol production and telomere length in European children
Associations of family affluence with cortisol production and telomere length in European children Open
UK Research and Innovation (Grants: MR/S03532X/1, MR/Y02012X/1), European Community (Grants: 874583, 308333).
View article: Personal exposure to air pollutants and immune system biomarkers in pregnant women
Personal exposure to air pollutants and immune system biomarkers in pregnant women Open
The immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. One-week personal measurements of exposure to nitrogen dioxide (NO 2 ), particulate mat…
View article: Outdoor air pollution, road traffic noise, and allostatic load in children aged 6–11 years: evidence from six European cohorts
Outdoor air pollution, road traffic noise, and allostatic load in children aged 6–11 years: evidence from six European cohorts Open
Emerging evidence suggests that exposure to air pollutants and road traffic noise triggers stress responses, which mediate physiological responses in multiple organs and tissues. However, epidemiological study in children is sparse. We aim…
View article: Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6–12 Years
Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6–12 Years Open
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6–12 years. Method: Data from 1,759 children belonging to the HELIX project cohorts and the Astu…
View article: The multi-omics signatures of telomere length in childhood
The multi-omics signatures of telomere length in childhood Open
Findings of this multi-omics study suggested an intricate interplay between telomere length, metabolism and immune responses, providing valuable insights into the molecular underpinnings of the early-life biological aging.
View article: Immediate and durable effects of maternal tobacco consumption on placental DNA methylation: a replication and discovery study
Immediate and durable effects of maternal tobacco consumption on placental DNA methylation: a replication and discovery study Open
An increasing number of epigenome-wide association studies report tobacco smoking-associated DNA methylation levels. However, comprehensive replication studies remain scarce, particularly in placenta, despite their crucial interest in such…
View article: Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort
Associations of exposure to outdoor PM2.5 and NO2 during pregnancy with childhood asthma, rhinitis, and eczema in a predominantly rural French mother-child cohort Open
Uncertainty remains regarding the effects of outdoor air pollution in rural areas on childhood asthma, rhinitis, and eczema. Although these diseases often coexist, few studies have examined the effects of air pollution on their multimorbid…
View article: Analyzing effect modifiers of the temperature-mortality relationship in the Paris region to identify social and environmental levers for more effective adaptation to heat
Analyzing effect modifiers of the temperature-mortality relationship in the Paris region to identify social and environmental levers for more effective adaptation to heat Open
Adaptation to heat is a major challenge for the Paris region (France). Based on fine-scale data for the 1,287 municipalities of the region over 2000-2017, we analyzed (time-serie design) the temperature-mortality relationship by territorie…
View article: Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children
Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children Open
Studies evaluating the benefits and risks of green spaces on children's health are scarce. The present study aimed to examine the associations between exposure to green spaces during pregnancy and early childhood with respiratory, cardiome…
View article: Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates
Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates Open
By combining improved exposure assessment and extensive placental epigenome coverage, we identified several novel genes associated with the exposure, possibly in a sex-specific manner.
View article: A multi-resolution ensemble model of three decision-tree-based algorithms to predict daily NO2 concentration in France 2005–2022
A multi-resolution ensemble model of three decision-tree-based algorithms to predict daily NO2 concentration in France 2005–2022 Open
Understanding and managing the health effects of Nitrogen Dioxide (NO2) requires high resolution spatiotemporal exposure maps. Here, we developed a multi-stage multi-resolution ensemble model that predicts daily NO2 concentration across co…
View article: Placental DNA methylation signatures of prenatal air pollution exposure and potential effects on birth outcomes: an analysis of three prospective cohorts
Placental DNA methylation signatures of prenatal air pollution exposure and potential effects on birth outcomes: an analysis of three prospective cohorts Open
French Agency for National Research, Fondation pour la Recherche Médicale, Fondation de France, and the Plan Cancer.