Joaninha Costa Rosa
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View article: A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma
A novel patient-derived cutaneous melanoma cell line reveals key features of metastatic melanoma Open
Introduction Cutaneous melanoma (CM) is an aggressive form of skin cancer, with rising incidence and poor prognosis at advanced stages. While early-stage CM typically carries a favorable prognosis, a small subset of patients relapses and p…
View article: HutchinsonÓ?s sign in congenital nail matrix nevus
HutchinsonÓ?s sign in congenital nail matrix nevus Open
Congenital nail matrix nevi (NMN) are a rare cause of melanonychia that may present with irregularity, asymmetry, and multicomponent pigmentation posing diagnostic challenges with subungual melanoma.We report a case of a 49-year-old female…
View article: Homozygous Loss of CDKN2 in Primary Cutaneous CD8(+) Lymphoma NOS
Homozygous Loss of CDKN2 in Primary Cutaneous CD8(+) Lymphoma NOS Open
Primary cutaneous acral CD8(+) lymphoma (AL) has been accepted as primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder in the revised WHO and updated WHO-EORTC lymphoma classifications. Commonly arising on the ears and …
View article: A rare T-cell lymphoma in an ankylosing spondylitis patient under immunosuppression with tumor necrosis factor inhibitor
A rare T-cell lymphoma in an ankylosing spondylitis patient under immunosuppression with tumor necrosis factor inhibitor Open
Lymphoproliferative disorders arising in a background of immune deficiency/dysregulation correspond to a spectrum of disorders ranging from non-noxious hyperplasias to aggressive lymphomas, mainly of B-cell type.We describe a case of an Ep…
View article: A case of scleroderma-like lesions as a cutaneous manifestation of carcinoid syndrome
A case of scleroderma-like lesions as a cutaneous manifestation of carcinoid syndrome Open
Scleroderma-like lesions are a rare sign of carcinoid syndrome which have been associated with poor prognosis. They differ from systemic sclerosis by involving preferentially the skin in the lower limbs, lacking Raynaud's phenomenon and ha…
View article: Calvarial tuberculosis in a paediatric patient: a diagnosis not to forget
Calvarial tuberculosis in a paediatric patient: a diagnosis not to forget Open
We report the case of a 10-year-old boy that presented with a palpable, painless, frontal lesion. Laboratory assessments were unremarkable and the patient was asymptomatic. Initial investigation, with a skull radiograph and unenhanced CT s…
View article: Cutaneous Adverse Events of Targeted Therapies and Immune-Checkpoint Inhibitors in Patients with Melanoma
Cutaneous Adverse Events of Targeted Therapies and Immune-Checkpoint Inhibitors in Patients with Melanoma Open
Targeted therapy and immunotherapy have markedly improved prognosis of advanced melanoma patients. With expanded use of these drugs, a range of cutaneous adverse events has emerged. Although the vast majority of adverse events are low-grad…
View article: High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma
High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma Open
Cutaneous melanoma is one of the most aggressive human cancers due to its high invasiveness. Germline mutations in high-risk melanoma susceptibility genes have been associated with development hereditary melanoma; however, most genetic cul…
View article: Eruptive Junctional Nevi Appearing During Langerhans Cell Histiocytosis Treatment
Eruptive Junctional Nevi Appearing During Langerhans Cell Histiocytosis Treatment Open
Langerhans cell histiocytosis (LCH) is a clonal neoplastic proliferation of immature Langerhans cells, with the V600E mutation in the BRAF oncogene present in approximately 60% of cases.The V600E mutation in the BRAF oncogene is also docum…