Joann Ravi YOU? Author Swipe

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Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway Open

Sanjay Khandelwal, Joann Ravi, Lubica Rauova, Alexandra Johnson, Grace M. Lee , et al. · 2018

The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasm…

Novel Immunoassay for Complement Activation by PF4/Heparin Complexes Open

Sanjay Khandelwal, Alexandra Johnson, Jian Liu, David A. Keire, Cynthia D. Sommers , et al. · 2018

Platelet factor 4 (PF4)/heparin and protamine/heparin (PRT/heparin) complexes elicit antigen-specific antibodies in 25 to 50% of heparin-exposed patients in certain clinical settings.[1] [2] In recent studies, we showed that antibody respo…