Explanipedia

Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures Open

Joanna E. Moodie, Colin R. Buchanan, Anna E. Fürtjes, Eleanor L.S. Conole, Aleks Stolicyn , et al. · 2025

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ( g )? and 2) what are the underly…

Cognitive dedifferentiation in later life: Longitudinal findings from the lothian birth cohort 1936 Open

Joanna E. Moodie, Janie Corley, Ian J. Deary, Simon R. Cox · 2025

Objectives In the cognitive ageing literature, the dedifferentiation hypothesis refers to cognitive skills becoming more interrelated in older adulthood. Here, we report evidence for cognitive dedifferentiation in the Lothian Birth Cohort …

Relative Strength Variability Measures for Brain Structural Connectomes and Their Relationship With Cognitive Functioning Open

Hon Wah Yeung, Colin R. Buchanan, Joanna E. Moodie, Ian J. Deary, Elliot M. Tucker‐Drob , et al. · 2025

In this work, we propose a new class of graph measures for weighted connectivity information in the human brain based on node relative strengths: relative strength variability (RSV), measuring susceptibility to targeted attacks, and hierar…

Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI Open

Anna E. Fürtjes, Isabelle F. Foote, Charley Xia, Gail Davies, Joanna E. Moodie , et al. · 2025

Cognitive dedifferentiation in later life: Longitudinal evidence from the Lothian Birth Cohort 1936 Open

Joanna E. Moodie, Janie Corley, Ian J. Deary, Simon R. Cox · 2025

In the cognitive ageing literature, the dedifferentiation hypothesis refers to cognitive skills becoming more interrelated in older adulthood. Here, we find evidence for cognitive dedifferentiation in the Lothian Birth Cohort 1936 (LBC1936…

Cognitive dedifferentiation in later life: Longitudinal evidence from the Lothian Birth Cohort 1936 Open

Joanna E. Moodie, Janie Corley, Ian J. Deary, Simon R. Cox · 2025

In the cognitive ageing literature, the dedifferentiation hypothesis refers to cognitive skills becoming more interrelated in older adulthood. Here, we find evidence for cognitive dedifferentiation in the Lothian Birth Cohort 1936 (LBC1936…

Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning Open

Hon Wah Yeung, Colin R. Buchanan, Joanna E. Moodie, Ian J. Deary, Elliot M. Tucker‐Drob , et al. · 2025

In this work, we propose a new class of graph measures for weighted connectivity information in the human brain based on node relative strengths: relative strength variability (RSV), measuring susceptibility to targeted attacks, and hierar…

DNA methylation-based predictors of metabolic traits in Scottish and Singaporean cohorts Open

Hannah M. Smith, Hong Kiat Ng, Joanna E. Moodie, Danni A. Gadd, Daniel L. McCartney , et al. · 2024

Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles Open

Joanna E. Moodie, Colin R. Buchanan, Anna E. Fürtjes, Eleanor L.S. Conole, Aleks Stolicyn , et al. · 2024

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ( g )? and 2) what are the underly…

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates Open

Anna E. Fürtjes, Isabelle F. Foote, Charley Xia, Gail Davies, Joanna E. Moodie , et al. · 2024

A measure of lifetime brain atrophy (LBA) obtained from a single magnetic resonance imaging (MRI) scan could be an attractive candidate to boost statistical power in uncovering novel genetic signals and mechanisms of neurodegeneration. We …

Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study Open

Danielle Page, Colin R. Buchanan, Joanna E. Moodie, Mathew A. Harris, Adele M. Taylor , et al. · 2024

Examining underlying neurostructural correlates of specific cognitive abilities is practically and theoretically complicated by the existence of the positive manifold (all cognitive tests positively correlate): if a brain structure is asso…

Methylome-wide studies of six metabolic traits Open

Hannah M. Smith, Hong Kiat Ng, Joanna E. Moodie, Danni A. Gadd, Daniel L. McCartney , et al. · 2024

Exploring the molecular correlates of metabolic health measures may identify the shared and unique biological processes and pathways that they track. Here, we performed epigenome-wide association studies (EWASs) of six metabolic traits: bo…

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open

Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio‐Gómez, Danni A. Gadd, Robert F. Hillary , et al. · 2024

General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning Open

Joanna E. Moodie, Sarah E. Harris, Mathew A. Harris, Colin R. Buchanan, Gail Davies , et al. · 2024

Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene's expression fluctuates across the brain may be governed by general rules. Quan…

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open

Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio‐Gómez, Danni A. Gadd, Robert F. Hillary , et al. · 2023

Background Blood-based biomarkers of brain health could provide a cost-effective contribution to detecting individuals at risk of dementia. Epigenetic scores (EpiScores) for blood protein levels have previously associated with several dise…

Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 Study Open

Danielle Page, Colin R. Buchanan, Mathew A. Harris, Joanna E. Moodie, Adele M. Taylor , et al. · 2023

Examining underlying neurostructural correlates of specific cognitive abilities is practically and theoretically complicated by the existence of the positive manifold (all cognitive tests positively correlate): if a brain structure is asso…

General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning Open

Joanna E. Moodie, Sarah E. Harris, Mathew A. Harris, Colin R. Buchanan, Gail Davies , et al. · 2023

Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene’s expression fluctuates across the brain may be governed by general rules. Quan…

Domain-specialised and domain-general neurocognitive substrates in language and music domains : contributions from ERP correlates of expectancy violations Open

Joanna E. Moodie · 2021

This thesis contributes to the interdisciplinary debate about the extent of shared and separable neurocognitive mechanisms between language and music processing. To achieve this, ERP (event-related potential) correlates of expectancy viola…

Fluctuating asymmetry in brain structure and general intelligence in 73-year-olds Open

Joanna E. Moodie, Stuart J. Ritchie, Simon R. Cox, Mathew A. Harris, Susana Muñoz Maniega , et al. · 2019

Structural Brain Asymmetry and General Intelligence in 73-Year-Olds Open

Joanna E. Moodie, Stuart J. Ritchie, Simon R. Cox, Mathew A. Harris, Susana Muñoz Maniega , et al. · 2019

Deviations from body symmetry are theorized to indicate developmental instability, and have small associations with low socioeconomic status (SES). Previous studies have reported small negative associations between body asymmetry and cogni…

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