Joanne Beckmann
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View article: Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection
Nasal mucosal IgA levels against SARS-CoV-2 and seasonal coronaviruses are low in children but boosted by reinfection Open
Repeated coronavirus infections in childhood drive progressive maturation of systemic immune responses into adulthood. Analyses of immune responses in children have focused primarily upon systemic assessment but the importance of mucosal i…
View article: Antibody Persistence After Primary SARS-CoV-2 Infection and Protection Against Future Variants Including Omicron in Adolescents: National, Prospective Cohort Study
Antibody Persistence After Primary SARS-CoV-2 Infection and Protection Against Future Variants Including Omicron in Adolescents: National, Prospective Cohort Study Open
Background: Antibodies are a measure of immunity after primary infection, which may help protect against further SARS-CoV-2 infections. They may also provide some cross-protection against SARS-CoV-2 variants. There are limited data on anti…
View article: 1929 Developing a transition pathway for adolescents with complex needs and learning disabilities
1929 Developing a transition pathway for adolescents with complex needs and learning disabilities Open
Objectives To co-develop a Transition pathway for adolescents with complex medical needs and learning disability in East London, we conducted a qualitative survey with patients and parents/carers regarding their experience of transitioning…
View article: Parents’ and teachers’ attitudes to and experiences of the implementation of COVID-19 preventive measures in primary and secondary schools following reopening of schools in autumn 2020: a descriptive cross-sectional survey
Parents’ and teachers’ attitudes to and experiences of the implementation of COVID-19 preventive measures in primary and secondary schools following reopening of schools in autumn 2020: a descriptive cross-sectional survey Open
Objective To assess implementation and ease of implementation of control measures in schools as reported by staff and parents. Design A descriptive cross-sectional survey. Setting Staff and parents/guardians of the 132 primary schools and …
View article: Perceptions of adolescents on the COVID-19 pandemic and returning to school: qualitative questionnaire survey, September 2020, England
Perceptions of adolescents on the COVID-19 pandemic and returning to school: qualitative questionnaire survey, September 2020, England Open
Background Little is known about the views of adolescents returning to secondary school during the current COVID-19 pandemic. Methods In September 2020, the UK Health Security Agency (UKHSA), formerly known as Public Health England (PHE),r…
View article: Immunological imprinting of humoral immunity to SARS-CoV-2 in children
Immunological imprinting of humoral immunity to SARS-CoV-2 in children Open
Omicron variants of SARS-CoV-2 are globally dominant and infection rates are very high in children. We determined immune responses following Omicron BA.1/2 infection in children aged 6-14 years and related this to prior and subsequent SARS…
View article: mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273 Open
Children and adolescents generally experience mild COVID-19. However, those with underlying physical health conditions are at a significantly increased risk of severe disease. Here, we present a comprehensive analysis of antibody and cellu…
View article: Secondary attack rates in primary and secondary school bubbles following a confirmed case: Active, prospective national surveillance, November to December 2020, England
Secondary attack rates in primary and secondary school bubbles following a confirmed case: Active, prospective national surveillance, November to December 2020, England Open
Background Following the full re-opening of schools in England and emergence of the SARS-CoV-2 Alpha variant, we investigated the risk of SARS-CoV-2 infection in students and staff who were contacts of a confirmed case in a school bubble (…
View article: Functional Ophthalmic Factors Associated With Extreme Prematurity in Young Adults
Functional Ophthalmic Factors Associated With Extreme Prematurity in Young Adults Open
Extreme prematurity is associated with an increased prevalence of visual and ocular deficits in young adulthood; this study suggests that, for individuals born EP, visual and ocular deficits appear to be partially independent of ROP status…
View article: SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements
SARS Antibody Testing in Children: Development of Oral Fluid Assays for IgG Measurements Open
We report on the first large-scale assessment of the suitability of oral fluids for detection of SARS-CoV-2 antibody obtained from healthy children attending school. The sample type (gingiva-crevicular fluid, which is a transudate of blood…
View article: Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection Open
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spik…
View article: Emergence of the Delta Variant and risk of SARS-CoV-2 infection in secondary school students and staff: prospective surveillance in 18 schools, England
Emergence of the Delta Variant and risk of SARS-CoV-2 infection in secondary school students and staff: prospective surveillance in 18 schools, England Open
Background The role of educational settings on SARS-CoV-2 infection and transmission remains controversial. We investigated SARS-CoV-2 infection, seroprevalence and seroconversions rates in secondary schools during the 2020/21 academic yea…
View article: mRNA COVID-19 vaccines induce enhanced antibody and cellular responses compared to ChAdOx1 or natural infection in children
mRNA COVID-19 vaccines induce enhanced antibody and cellular responses compared to ChAdOx1 or natural infection in children Open
We present a comprehensive analysis of antibody and cellular responses in children aged 12-16 years who received COVID-19 vaccination with ChAdOx1 (n=6) or mRNA vaccine (mRNA-1273 or BNT162b2, n=9) using a 12-week extended-interval schedul…
View article: Feasibility and acceptability of SARS-CoV-2 testing and surveillance in primary school children in England: Prospective, cross-sectional study
Feasibility and acceptability of SARS-CoV-2 testing and surveillance in primary school children in England: Prospective, cross-sectional study Open
Background The reopening of schools during the COVID-19 pandemic has raised concerns about widespread infection and transmission of SARS-CoV-2 in educational settings. In June 2020, Public Health England (PHE) initiated prospective nationa…
View article: Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England
Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: active prospective surveillance, December 2020 to March 2021, England Open
Background In England, the rapid spread of the SARS-Cov-2 Alpha (B.1.1.7) variant from November 2020 led to national lockdown, including school closures in January 2021. We assessed SARS-CoV-2 infection, seroprevalence and seroconversion i…
View article: Antibody persistence and neutralising activity in primary school students and staff: prospective active surveillance, June to December 2020, England
Antibody persistence and neutralising activity in primary school students and staff: prospective active surveillance, June to December 2020, England Open
Introduction SARS-CoV-2 serological studies have so far focused mainly on adults. Public Health England initiated prospective, longitudinal SARS-CoV-2 sero-surveillance in schools across England after the first national lockdown, which all…
View article: SARS-CoV-2 IgG detection in human oral fluids
SARS-CoV-2 IgG detection in human oral fluids Open
Seroepidemiological studies to monitor antibody kinetics are important for assessing the extent and spread of SARS-CoV-2 in a population. Non-invasive sampling methods are advantageous to reduce the need for venepuncture, which may be a ba…
View article: Implementation of COVID-19 Preventive Measures in Primary and Secondary Schools Following Reopening of Schools in Autumn 2020; A Cross-Sectional Study of Parents’ and Teachers’ Experiences in England
Implementation of COVID-19 Preventive Measures in Primary and Secondary Schools Following Reopening of Schools in Autumn 2020; A Cross-Sectional Study of Parents’ and Teachers’ Experiences in England Open
Objective The main objective was to assess implementation of and ease of implementation of control measures in schools as reported by staff and parents. Design Cross-sectional study. Setting Staff and parents/guardian participants in the 1…
View article: Children develop robust and sustained cross-reactive spike-specific immune responses following SARS-CoV-2 infection
Children develop robust and sustained cross-reactive spike-specific immune responses following SARS-CoV-2 infection Open
SARS-CoV-2 infection is generally mild or asymptomatic in children but the biological basis for this is unclear. We studied the profile of antibody and cellular immunity in children aged 3-11 years in comparison with adults. Antibody respo…
View article: Implementation of preventive measures to prevent COVID-19: a national study of English primary schools in summer 2020
Implementation of preventive measures to prevent COVID-19: a national study of English primary schools in summer 2020 Open
We examined the feasibility of implementing preventive measures to prevent SARS-CoV-2 transmission across 105 English primary schools in summer 2020 via a survey and interviews with headteachers. High rates of implementation of most recomm…