Joanne Kite
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View article: Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11
Spatial proteomics identifies a CRTC-dependent viral signaling pathway that stimulates production of interleukin-11 Open
Appropriate cellular recognition of viruses is essential for the generation of an effective innate and adaptive immune response. Viral sensors and their downstream signaling components thus provide a crucial first line of host defense. Man…
View article: HCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L
HCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L Open
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host’s endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade major histocompatibility complex class I (MHC-I) and prevent antigen presentation. Beyond MH…
View article: Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function
Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function Open
Many viruses downregulate their cognate receptors, facilitating virus replication and pathogenesis via processes that are not yet fully understood. In the case of herpes simplex virus 1 (HSV1), the receptor binding protein glycoprotein D (…
View article: Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection
Quantitative proteomics defines mechanisms of antiviral defence and cell death during modified vaccinia Ankara infection Open
Modified vaccinia Ankara (MVA) virus does not replicate in human cells and is the vaccine deployed to curb the current outbreak of mpox. Here, we conduct a multiplexed proteomic analysis to quantify >9000 cellular and ~80% of viral protein…
View article: Quantitative temporal analysis of modified vaccinia Ankara, the monkeypox and smallpox vaccine
Quantitative temporal analysis of modified vaccinia Ankara, the monkeypox and smallpox vaccine Open
Modified vaccinia Ankara (MVA) immunisation is being deployed to curb the current outbreak of monkeypox in multiple countries1. Originally authorized for vaccination against smallpox, MVA is a vaccinia virus (VACV) strain that does not rep…
View article: Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1
Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1 Open
Herpes simplex virus 1 (HSV1) infects the stratified epithelia of the epidermis, oral or genital mucosa, where the main cell type is the keratinocyte. Here we have used nTERT human keratinocytes to generate a CRISPR-Cas9 knockout (KO) of t…
View article: Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1
Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1 Open
Herpes simplex virus 1 (HSV1) infects the stratified epithelia of the epidermis, oral or genital mucosa, where the main cell type is the keratinocyte. Here we have used nTERT human keratinocytes to generate a CRISPR-Cas9 knockout (KO) of t…
View article: Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment
Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment Open
Cellular transport pathways play a fundamental role in secretion and membrane biogenesis. Enveloped viruses exploit these pathways to direct their membrane proteins to sites of envelopment and, as such, are powerful tools for unraveling su…
View article: Novel role for ESCRT-III component CHMP4C in the integrity of the endocytic network utilized for herpes simplex virus envelopment
Novel role for ESCRT-III component CHMP4C in the integrity of the endocytic network utilized for herpes simplex virus envelopment Open
Summary Enveloped viruses exploit cellular trafficking pathways for their morphogenesis, providing potential scope for the development of new antiviral therapies. We have previously shown that herpes simplex virus 1 (HSV1) utilises recycli…