Joanne T. M. Tan
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View article: Spontaneous Myocardial Infarction in a Translational Porcine Model of Coronary Atherosclerosis: A Pilot Study
Spontaneous Myocardial Infarction in a Translational Porcine Model of Coronary Atherosclerosis: A Pilot Study Open
This pilot study characterizes the spectrum of atherosclerotic coronary artery pathologies in a porcine model of streptozotocin-induced diabetes, with a particular focus on the natural progression of atherosclerotic plaques. Four pigs (des…
View article: Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair
Breaking and Remaking: Using Organoids to Model Gastric Tissue Damage and Repair Open
The stomach epithelium is a highly dynamic tissue that undergoes continuous self-renewal and responds robustly to injury through tightly regulated repair processes. Organoids have emerged as powerful tools for modelling gastrointestinal bi…
View article: Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects
Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects Open
View article: Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects
Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects Open
Background Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs). How…
View article: Identification and removal of system-induced autofluorescence in miniaturized fiber-optic fluorescence endoscopes
Identification and removal of system-induced autofluorescence in miniaturized fiber-optic fluorescence endoscopes Open
Miniaturized fiber-optic fluorescence endoscopes play a crucial role in medical diagnostics and research, but system-induced autofluorescence remains a significant challenge, particularly in single-fiber setups. While recent advances, such…
View article: RISK STRATIFICATION OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: THE KASL PATHWAY
RISK STRATIFICATION OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE: THE KASL PATHWAY Open
View article: Identification and Removal of System-Induced Autofluorescence in Miniaturized Fiber-optic Fluorescence Endoscopes
Identification and Removal of System-Induced Autofluorescence in Miniaturized Fiber-optic Fluorescence Endoscopes Open
Miniaturized fiber-optic fluorescence endoscopes play a crucial role in medical diagnostics and research, but system-induced autofluorescence remains a significant challenge, particularly in single-fiber setups. While recent advances, such…
View article: 3D-printed micro-axicon enables extended depth-of-focus intravascular optical coherence tomography in vivo
3D-printed micro-axicon enables extended depth-of-focus intravascular optical coherence tomography in vivo Open
View article: Connected Yet Constrained: Examining the Impact of Social Media Use on Creativity
Connected Yet Constrained: Examining the Impact of Social Media Use on Creativity Open
View article: Connected Yet Constrained: Investigating the Impact of Social Media Use on Creativity
Connected Yet Constrained: Investigating the Impact of Social Media Use on Creativity Open
View article: Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia
Reconstituted high-density lipoproteins rescue diabetes-impaired endothelial cell metabolic reprograming and angiogenic responses to hypoxia Open
Objective: Impaired angiogenic responses to ischemia underlie diabetic vascular complications. Reconstituted high-density lipoproteins (rHDL) have proangiogenic effects in diabetes. The pyruvate dehydrogenase kinase 4 (PDK4)/pyruvate dehyd…
View article: Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta
Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta Open
View article: 3D-printed axicon enables extended depth-of-focus intravascular optical coherence tomography
3D-printed axicon enables extended depth-of-focus intravascular optical coherence tomography Open
A fundamental challenge in endoscopy is how to fabricate a small fiber-optic probe that can achieve comparable function to probes with large, complicated optics (e.g., high resolution and extended depth of focus). To achieve high resolutio…
View article: Exercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet
Exercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet Open
Circadian disruption causes glucose intolerance, cardiac fibrosis, and adipocyte dysfunction in sand rats (Psammomys obesus). Exercise intervention can improve glucose metabolism, insulin sensitivity, adipose tissue function and protect ag…
View article: Female Psammomys obesus Are Protected from Circadian Disruption-Induced Glucose Intolerance, Cardiac Fibrosis and Adipocyte Dysfunction
Female Psammomys obesus Are Protected from Circadian Disruption-Induced Glucose Intolerance, Cardiac Fibrosis and Adipocyte Dysfunction Open
Circadian disruption increases the development of cardiovascular disease and diabetes. We found that circadian disruption causes glucose intolerance, cardiac fibrosis and adipocyte tissue dysfunction in male sand rats, Psammomys obesus. Wh…
View article: Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system
Detection of atherosclerotic plaques with HDL-like porphyrin nanoparticles using an intravascular dual-modality optical coherence tomography and fluorescence system Open
Atherosclerosis is the build-up of fatty plaques within blood vessel walls, which can occlude the vessels and cause strokes or heart attacks. It gives rise to both structural and biomolecular changes in the vessel walls. Current single-mod…
View article: Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease
Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease Open
Despite the emergence of novel diagnostic, pharmacological, interventional, and prevention strategies, atherosclerotic cardiovascular disease remains a significant cause of morbidity and mortality. Nanoparticle (NP)-based platforms encompa…
View article: TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis
TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis Open
Angiogenesis is a critical physiological response to ischemia but becomes pathological when dysregulated and driven excessively by inflammation. We recently identified a novel angiogenic role for tripartite-motif-containing protein 2 (TRIM…
View article: TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis
TRIM2 Selectively Regulates Inflammation-Driven Pathological Angiogenesis without Affecting Physiological Hypoxia-Mediated Angiogenesis Open
Angiogenesis is a critical physiological response to ischemia but becomes pathological when dysregulated and driven excessively by inflammation. We recently identified a novel angiogenic role for tripartite-motif-containing protein 2 (TRIM…
View article: Multifunctional biomimetic porphyrin-lipid nanoparticles – novel nanoscale theranostics for atherosclerotic cardiovascular disease
Multifunctional biomimetic porphyrin-lipid nanoparticles – novel nanoscale theranostics for atherosclerotic cardiovascular disease Open
Background High-density lipoprotein (HDL) nanoagents have unrealized potential for atherosclerosis theranostics. Porphyrin-lipid HDL mimetic nanoparticles (Por-HDL-NPs) incorporate porphyrin-lipid which permits near infrared fluorescence i…
View article: Embryonic Origins of Bipotent Endothelial-macrophage Progenitor Cells in Postnatal Aorta
Embryonic Origins of Bipotent Endothelial-macrophage Progenitor Cells in Postnatal Aorta Open
View article: Deletion of the Asialyloglycoprotein Receptor-1 (ASGR-1) Causes Athero-protective Effects in vitro and in vivo and Changes the Plaque Glycome
Deletion of the Asialyloglycoprotein Receptor-1 (ASGR-1) Causes Athero-protective Effects in vitro and in vivo and Changes the Plaque Glycome Open
View article: Inhibitory and Metabolic Effects of Diabetes on Yolk Sac-Derived Endothelial-Macrophage Progenitors in Postnatal Murine Tissues
Inhibitory and Metabolic Effects of Diabetes on Yolk Sac-Derived Endothelial-Macrophage Progenitors in Postnatal Murine Tissues Open
View article: Role of Endothelial-Macrophage Progenitor Cells as an “Outside-in” Driver of Plaque Growth and Stability in Atherosclerosis
Role of Endothelial-Macrophage Progenitor Cells as an “Outside-in” Driver of Plaque Growth and Stability in Atherosclerosis Open
View article: Editorial: Emerging roles of miRNAs in cardiovascular disease
Editorial: Emerging roles of miRNAs in cardiovascular disease Open
EDITORIAL article Front. Cardiovasc. Med., 28 February 2023Sec. Atherosclerosis and Vascular Medicine Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1144849
View article: 902 NKX019, an off-the-shelf CD19 CAR-NK cell, mediates improved anti-tumor activity and persistence in combination with CD20-directed therapeutic mAbs
902 NKX019, an off-the-shelf CD19 CAR-NK cell, mediates improved anti-tumor activity and persistence in combination with CD20-directed therapeutic mAbs Open
Background NKX019 is an investigational CD19-targeting chimeric antigen receptor (CAR) natural killer (NK) cell therapy with engineered persistence for treating B cell malignancies. NKX019 exhibits more rapid cytotoxic kinetics than CD19-d…
View article: P-162: Validation of the second revision of the international staging system in a real-world myeloma population: a myeloma and related diseases registry study
P-162: Validation of the second revision of the international staging system in a real-world myeloma population: a myeloma and related diseases registry study Open
View article: Inhibition of Vascular Inflammation by Apolipoprotein A-IV
Inhibition of Vascular Inflammation by Apolipoprotein A-IV Open
Background Apolipoprotein (apo) A-IV, the third most abundant apolipoprotein in human high density lipoproteins (HDLs), inhibits intestinal and systemic inflammation. This study asks if apoA-IV also inhibits acute vascular inflammation. Me…
View article: Diabetes impairs endothelial cell metabolic reprogramming and angiogenic responses to hypoxia, which are rescued by reconstituted high-density lipoproteins
Diabetes impairs endothelial cell metabolic reprogramming and angiogenic responses to hypoxia, which are rescued by reconstituted high-density lipoproteins Open
Aims Diabetes-impaired angiogenic responses to ischemia contribute to vascular complications such as chronic wounds and a poorer prognosis post-myocardial infarction. Diabetes disrupts mechanisms involved in endothelial cell (EC) adaptatio…
View article: A roadmap of strategies to support cardiovascular researchers: from policy to practice
A roadmap of strategies to support cardiovascular researchers: from policy to practice Open