Explanipedia

Peptide and neuropeptide diversity and function in bivalves Open

Zhi Li, João C. R. Cardoso, Deborah M. Power · 2025

The Mollusca are the second most specious animal phyla after arthropods. They are morphologically diverse and exhibit high variability of their nervous systems, which have evolved as they adapted to an extreme range of ecological niches. R…

Fluxo digital com laminados para correção de pigmentação por Tetraciclina - um relato de caso Open

R Felix, João C. R. Cardoso · 2025

A tetraciclina é um medicamento que como efeito colateral, se liga ao esmalte dentário e à dentina em desenvolvimento, resultando em manchas que variam de amarelo a marrom, e se tornam mais visíveis com o tempo, acometendo especialmente cr…

Activation profile of the Atlantic salmon (Salmo salar) calcium-sensing receptor (Casr) by selected L-amino acids Open

Ana S. Gomes, Virginie Gélébart, Rute C. Félix, João C. R. Cardoso, Fabian Zimmermann , et al. · 2025

The potential of shallow geothermal energy in Norway and Portugal: optimized borehole design for two different climate conditions Open

António Figueiredo, Raoof Gholami, Mohsen Assadi, João C. R. Cardoso · 2025

Thermal Characterization of Soils in Aveiro and Lisbon for Shallow Geothermal Applications: A Study Using Transient Methods Open

Rajendra Roka, Ana Vieira, António Figueiredo, Abel G.M. Ferreira, João C. R. Cardoso · 2025

Neuropeptides regulate shell growth in the Mediterranean mussel (Mytilus galloprovincialis) Open

Zhi Li, Maoxiao Peng, Rute C. Félix, João C. R. Cardoso, Deborah M. Power · 2024

In bivalves, which are molluscs enclosed in a biomineralized shell, a diversity of neuropeptide precursors has been described but their involvement in shell growth has been largely neglected. Here, using a symmetric marine bivalve, the Med…

Evolution of chitin-synthase in molluscs and their response to ocean acidification Open

Maoxiao Peng, João C. R. Cardoso, Deborah M. Power · 2024

Chitin-synthase (CHS) is found in most eukaryotes and has a complex evolutionary history. Research into CHS has mainly been in the context of biomineralization of mollusc shells an area of high interest due to the consequences of ocean aci…

Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii Open

Cármen Sousa, Maoxiao Peng, Pedro M. Guerreiro, João C. R. Cardoso, Liangbiao Chen , et al. · 2024

The genome evolution of Antarctic notothenioids has been modulated by their extreme environment over millennia and more recently by human-caused constraints such as overfishing and climate change. Here we investigated the characteristics o…

Revisiting the evolution of Family B1 GPCRs and ligands: Insights from mollusca Open

João C. R. Cardoso, Jennifer C. Mc Shane, Zhi Li, Maoxiao Peng, Deborah M. Power · 2024

Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they play a central role in many biological processes including endocrine, gastrointestinal, cardiovascular and reproductio…

Core genes of biomineralization and cis-regulatory long non-coding RNA regulate shell growth in bivalves Open

Maoxiao Peng, João C. R. Cardoso, Gareth A. Pearson, Adelino V. M. Canário, Deborah M. Power · 2023

LncRNAs are putative regulatory factors of the bivalve biomineralization toolbox. In the Ostreidae family of bivalves biomineralization-related genes are cis-regulated by lncRNA and modify the planar growth rate and spatial orientation of …

[Artículo traducido] Granuloma anular papular generalizado: una presentación similar a pseudoxantoma elástico Open

Ricardo Calado, Carlos Eduardo da Silva Figueiredo, João C. R. Cardoso, H.S. Oliveira · 2023

Prótese fixa completa em zircônia superior seguindo protocolo clínico digital ful Open

João C. R. Cardoso, Rafael Perdomo Felix · 2023

Atualmente, a perda dos últimos dentes de uma ou ambas arcadas é realidade clínica de muitos pacientes. Nesse caso clínico, o paciente AAH compareceu ao consultório particular com reabilitação fixa superior apresentando os dentes pilares c…

Fluxo digital em cirurgia de acc e reabilitação com laminados cerâmicos Open

Rafael Perdomo Felix, Luciana Dondonis Daudt, João C. R. Cardoso, Cassiano Mendes Nobre do Espírito Santo, Karen da Rosa Gallas , et al. · 2022

O fluxo digital, hoje em dia, se tornou um grande aliado não apenas nos quesi-tos estéticos, sendo uma realidade também nos planejamentos cirúrgicos. Em casos com linha de sorriso alta, exposição acentuada de gengiva e conse-quentemente de…

PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek’s Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates Open

Jason S. W. On, Liuru Su, Hong Shen, Aloysius Wilfred Raj Arokiaraj, João C. R. Cardoso , et al. · 2022

The Hatschek’s pit in the cephalochordate amphioxus, an invertebrate deuterostome basal to chordates is suggested to be the functional homolog structure of the vertebrate adenohypophysis based on anatomy and expression of homologous neuroe…

Domain-Dependent Evolution Explains Functional Homology of Protostome and Deuterostome Complement C3-Like Proteins Open

Maoxiao Peng, Zhi Li, João C. R. Cardoso, Donghong Niu, Xiaojun Liu , et al. · 2022

Complement proteins emerged early in evolution but outside the vertebrate clade they are poorly characterized. An evolutionary model of C3 family members revealed that in contrast to vertebrates the evolutionary trajectory of C3-like genes…

Behind a Leonine Facies Open

Mariana Batista, João C. R. Cardoso, Américo Figueiredo · 2022

Toll-Like Receptor Evolution: Does Temperature Matter? Open

Cármen Sousa, Stefan A. Fernandes, João C. R. Cardoso, Ying Wang, Wanying Zhai , et al. · 2022

Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique tele…

[Artículo traducido] Tras la facies leonina Open

Mariana Batista, João C. R. Cardoso, Américo Figueiredo · 2021

Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect Allatostatins Open

Zhi Li, João C. R. Cardoso, Maoxiao Peng, João P. S. Inácio, Deborah M. Power · 2021

The allatostatins (ASTs), AST-A, AST-B and AST-C, have mainly been investigated in insects. They are a large group of small pleotropic alloregulatory neuropeptides that are unrelated in sequence and activate receptors of the rhodopsin G-pr…

Aspectos reprodutivos de orquídeas em ambientes de Vereda do Cerrado Open

João C. R. Cardoso · 2021

Evolution and Potential Function in Molluscs of Neuropeptide and Receptor Homologues of the Insect AllatostatinsDataSheet_1.pdfDataSheet_2.pdfDataSheet_3.pdfDataSheet_4.pdfDataSheet_5.pdfDataSheet_6.pdfTable_1.xlsxTable_2.docx Open

Zhi Li, João C. R. Cardoso, Maoxiao Peng, João P. S. Inácio, Deborah M. Power · 2021

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish Open

Babak Najafpour, João C. R. Cardoso, Adelino V. M. Canário, Deborah M. Power · 2020

The complement system comprises a large family of plasma proteins that play a central role in innate and adaptive immunity. To better understand the evolution of the complement system in vertebrates and the contribution of complement to fi…

Corrigendum: Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) Open

João C. R. Cardoso, Manuel G. Garcia, Deborah M. Power · 2020

[This corrects the article DOI: 10.3389/fnins.2020.00366.].

Deciphering mollusc shell production: the roles of genetic mechanisms through to ecology, aquaculture and biomimetics Open

Melody S. Clark, Lloyd S. Peck, Jaison Arivalagan, Thierry Backeljau, Sophie Berland , et al. · 2020

Most molluscs possess shells, constructed from a vast array of microstructures and architectures. The fully formed shell is composed of calcite or aragonite. These CaCO 3 crystals form complex biocomposites with proteins, which although ty…

Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doublings Open

João C. R. Cardoso, Christina A Bergqvist, Dan Larhammar · 2020

The ancestor of gnathostomes (jawed vertebrates) is generally considered to have undergone two rounds of whole genome duplication (WGD). The timing of these WGD events relative to the divergence of the closest relatives of the gnathostomes…

Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) Open

João C. R. Cardoso, Manuel García García, Deborah M. Power · 2020

Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell…

The calcitonin-like system is an ancient regulatory system of biomineralization Open

João C. R. Cardoso, Rute C. Félix, Vinicius S. Ferreira, Maoxiao Peng, Xushuai Zhang , et al. · 2020

Holothurians have a reduced GPCR and odorant receptor-like repertoire compared to other echinoderms Open

Nathalie Marquet, João C. R. Cardoso, Bruno Louro, Stefan A. Fernandes, Sandra C. Silva , et al. · 2020

Cartilage acidic protein 1 promotes increased cell viability, cell proliferation and energy metabolism in primary human dermal fibroblasts Open

Sophia Letsiou, Rute C. Félix, João C. R. Cardoso, Liliana Anjos, Ana L. G. Mestre , et al. · 2020

A Blood-Free Diet to Rear Anopheline Mosquitoes Open

Joana Marques, João C. R. Cardoso, Rute C. Félix, Deborah M. Power, Henrique Silveira · 2020

Malaria research requires large-scale breeding and production conditions for mosquitoes (Anopheles spp.) in captivity. The sustainable and reliable production of mosquitoes is currently inhibited by the supply of fresh vertebrate blood. Al…

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