João F. Crispim
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View article: Semi‐synthetic degradable notochordal cell‐derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization
Semi‐synthetic degradable notochordal cell‐derived matrix hydrogel for use in degenerated intervertebral discs: Initial in vitro characterization Open
Low back pain is the leading cause of disability worldwide, but current therapeutic interventions are palliative or surgical in nature. Loss of notochordal cells (NCs) and degradation of the healthy matrix in the nucleus pulposus (NP), the…
View article: Neo‐cartilage formation using human nondegenerate versus osteoarthritic chondrocyte‐derived cartilage organoids in a viscoelastic hydrogel
Neo‐cartilage formation using human nondegenerate versus osteoarthritic chondrocyte‐derived cartilage organoids in a viscoelastic hydrogel Open
Current regenerative cartilage therapies are associated with several drawbacks such as dedifferentiation of chondrocytes during expansion and the formation of fibrocartilage. Optimized chondrocyte expansion and tissue formation could lead …
View article: Introdução
Introdução Open
In the evolution of Humanity, communities emerge as a strategy for optimizing individuals' resources. The sharing of these resources ensures greater physical security (from predators) and security of supply (specialization in hunting and, …
View article: Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials (Adv. Mater. 42/2021)
Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials (Adv. Mater. 42/2021) Open
Cell–Material Tethering Cells need to sense their environment in order to survive and function. In article number 2102660, Tom Kamperman, Jeroen Leijten, and co-workers present an enzymatic crosslinking strategy that can tether non-cell-ad…
View article: Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials
Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials Open
Cell–matrix interactions govern cell behavior and tissue function by facilitating transduction of biomechanical cues. Engineered tissues often incorporate these interactions by employing cell‐adhesive materials. However, using constitutive…
View article: Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants
Self‐Oxygenation of Tissues Orchestrates Full‐Thickness Vascularization of Living Implants Open
Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full‐thickness vascularization that is required for long‐term survival of living implants has remained a grand challen…
View article: The regenerative effect of different growth factors and platelet lysate on meniscus cells and mesenchymal stromal cells and proof of concept with a functionalized meniscus implant
The regenerative effect of different growth factors and platelet lysate on meniscus cells and mesenchymal stromal cells and proof of concept with a functionalized meniscus implant Open
Meniscus regeneration could be enhanced by targeting meniscus cells and mesenchymal stromal cells (MSCs) with the right growth factors. Combining these growth factors with the Collagen Meniscus Implant (CMI®) could accelerate cell ingrowth…
View article: De novo neo-hyaline-cartilage from bovine organoids in viscoelastic hydrogels
De novo neo-hyaline-cartilage from bovine organoids in viscoelastic hydrogels Open
View article: VEGF functionalization of suture tape results in decreased graft inflammatory and catabolic response in a rabbit model of ACL reconstruction
VEGF functionalization of suture tape results in decreased graft inflammatory and catabolic response in a rabbit model of ACL reconstruction Open
IntroductionImproving ligament reconstruction biology may potentially be achieved through capturing autologous circulating factors such as vascular endothelial growth factor (VEGF) using commercially available biomaterials.ObjectivesTo eva…
View article: Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs
Characterization of biomaterials intended for use in the nucleus pulposus of degenerated intervertebral discs Open
View article: Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye Open
Purpose: To evaluate visual outcomes of levodopa treatment associated with full occlusion of the dominant eye in patients with refractory amblyopia. Methods: A prospective study of 19 attended patients who were subject to treatment with Le…
View article: Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs
Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogs Open
View article: Clinical Evaluation of Dry Eye Syndrome in Patients with Proliferative Diabetic Retinopathy and Laser Therapy Indication
Clinical Evaluation of Dry Eye Syndrome in Patients with Proliferative Diabetic Retinopathy and Laser Therapy Indication Open
Background: Studies have shown a higher incidence of dry eye among patients with diabetes compared to patients without diabetes. However, information regarding dry eye in patients with proliferative diabetic retinopathy and laser therapy i…
View article: From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation
From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation Open
Bioinstructive scaffolds for regenerative medicine are characterized by their intrinsic properties that are capable of directing cell response and promoting wound healing.
View article: Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye
Treatment of refractory amblyopia with levodopa associated with full-time occlusion in the dominant eye Open
Purpose: To evaluate visual outcomes of levodopa treatment associated with full occlusion of the dominant eye in patients with refractory amblyopia. Methods: A prospective study of 19 attended patients who were subject to treatment with Le…
View article: Chloral Hydrate as a Sedating Agent for Neurodiagnostic Procedures in Children
Chloral Hydrate as a Sedating Agent for Neurodiagnostic Procedures in Children Open
View article: Refractive and Visual Outcomes of Different Intraocular Lenses with Femtosecond Laser Cataract Surgery: The Expectation of Independence from Spectacles
Refractive and Visual Outcomes of Different Intraocular Lenses with Femtosecond Laser Cataract Surgery: The Expectation of Independence from Spectacles Open
Purpose: To evaluate the visual performance of different types of intraocular lens (IOL) in eyes submitted to femtosecond laser (FSL) cataract surgery and to analyze whether this technology could result in spectacles independence. Design: …
View article: Cross‐Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro
Cross‐Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro Open
Tendon and ligament (T/L) pathologies account for a significant portion of musculoskeletal injuries and disorders. Tissue engineering has emerged as a promising solution in the regeneration of both tissues. Specifically, the use of multipo…
View article: Clinical experience with the first 40 cases with femtosecond laser cataract surgery technology: safety of the learning curve
Clinical experience with the first 40 cases with femtosecond laser cataract surgery technology: safety of the learning curve Open
Objective: To evaluate the introduction of the femtosecond laser (FSL) to perform the key steps of the traditional cataract surgery process and the operational difficulties and safety of this new technology during routine use in an operati…