João Carlos Fernandes
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View article: #1096 Ultrafiltration rate and interleukin-6 levels are independent predictors of erythropoietin resistance in chronic hemodialysis patients
#1096 Ultrafiltration rate and interleukin-6 levels are independent predictors of erythropoietin resistance in chronic hemodialysis patients Open
Background and Aims Anemia is common in patients under regular hemodialysis therapy. Despite treatment with erythropoiesis-stimulating agents (ESA), hypo-responsiveness to this therapy can occur (refractory cases). We studied the associati…
View article: CARCINOMA DE CÉLULAS PEQUENAS EM PULMÃO ASSOCIADO À SÍNDROME DE SECREÇÃO INAPROPRIADA DO HORMÔNIO ANTIDIURÉTICO: UM RELATO DE CASO
CARCINOMA DE CÉLULAS PEQUENAS EM PULMÃO ASSOCIADO À SÍNDROME DE SECREÇÃO INAPROPRIADA DO HORMÔNIO ANTIDIURÉTICO: UM RELATO DE CASO Open
O câncer de pulmão é a neoplasia de maior mortalidade no mundo inteiro. Além do seu grande impacto na sobrevida, a presença de síndromes associadas diminui drasticamente a qualidade de vida dos pacientes. A Síndrome da secreção Inapropriad…
View article: MORMO EQUÍDEO: DA BACTÉRIA AO DIAGNÓSTICO
MORMO EQUÍDEO: DA BACTÉRIA AO DIAGNÓSTICO Open
View article: MECANISMOS IMUNOLÓGICOS CONTRA INFECÇÕES BACTERIANAS: IMUNIDADE INATA E ADAPTATIVA
MECANISMOS IMUNOLÓGICOS CONTRA INFECÇÕES BACTERIANAS: IMUNIDADE INATA E ADAPTATIVA Open
View article: Breaking the virus: Yeast glucans as an effective alternative to acyclovir in HSVI treatment
Breaking the virus: Yeast glucans as an effective alternative to acyclovir in HSVI treatment Open
Glucans, structural polysaccharides in the yeast cell wall, are known for their biological and immunomodulatory capacities, helping in prevention and management of infections. Herpes simplex virus type 1 (HSVI) is a prevalent infection tha…
View article: USE OF RGB DRONE SENSORS TO ESTIMATE VEGETATION BIOMASS IN A SEMIARID REGION
USE OF RGB DRONE SENSORS TO ESTIMATE VEGETATION BIOMASS IN A SEMIARID REGION Open
RESUMO - As estimativas dos estoques de biomassa vegetal em pastagens utilizando técnicas de sensoriamento remoto, apesar de serem amplamente utilizadas ultimamente, ainda são incertas devido ao padrão tridimensional e desigual de crescime…
View article: Exploring Cannabidiol (CBD) and Cannabigerol (CBG) Safety Profile and Skincare Potential
Exploring Cannabidiol (CBD) and Cannabigerol (CBG) Safety Profile and Skincare Potential Open
Cannabinoids have long been known for their bioactive properties, with their topical application as anti-inflammatory compounds being at the forefront of research for the past decade. Concurrently, the cosmetic market is a fast-growing ind…
View article: Modified Cellulose Nanocrystals Encapsulating Cannabigerol: A Step Forward in Controlling Intestinal Inflammatory Disorders
Modified Cellulose Nanocrystals Encapsulating Cannabigerol: A Step Forward in Controlling Intestinal Inflammatory Disorders Open
Cannabigerol (CBG) from Cannabis sativa L. is known for its anti-inflammatory, antibacterial, and antioxidant properties, showing potential against intestinal inflammation. However, its lipophilic nature limits its absorption and stability…
View article: Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model
Exploring yeast glucans for vaccine enhancement: Sustainable strategies for overcoming adjuvant challenges in a SARS-CoV-2 model Open
Vaccine adjuvants are important for enhancing vaccine efficacy, and although aluminium salts (Alum) are the most used, their limited ability to induce specific immune responses has spurred the search for new adjuvants. However, many adjuva…
View article: Qualidade de vida em doentes com insuficiência cardíaca no Centro de Portugal
Qualidade de vida em doentes com insuficiência cardíaca no Centro de Portugal Open
Objetivo: Avaliar e comparar a qualidade de vida (QdV) genérica e específica de doentes sofrendo de insuficiência cardíaca (DIC) e verificar a sua relação com elementos sociodemográficos e de morbilidade. Métodos: Estudo observacional tran…
View article: Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis
Impact of TNFRSF1B (rs3397, rs1061624 and rs1061622) and IL6 (rs1800796, rs1800797 and rs1554606) Gene Polymorphisms on Inflammatory Response in Patients with End-Stage Kidney Disease Undergoing Dialysis Open
We aimed to study the impact of polymorphisms in the genes encoding interleukin-6 (IL6) and tumor necrosis factor receptor-2 (TNFR2), reported to be mortality risk predictors, in patients with end-stage kidney disease (ESKD) undergoing dia…
View article: The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019 Open
View article: #1358 The association between TNFRSF1B rs1061624 polymorphism and hypertension in end-stage kidney disease patients on dialysis
#1358 The association between TNFRSF1B rs1061624 polymorphism and hypertension in end-stage kidney disease patients on dialysis Open
Background and Aims In chronic kidney disease (CKD), hypertension (HT) is commonly found during its development and is a leading cause for its progression. HT, dyslipidemia and visceral obesity are among the components of metabolic syndrom…
View article: Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application
Circular economyeast: Saccharomyces cerevisiae as a sustainable source of glucans and its safety for skincare application Open
Glucans, a polysaccharide naturally present in the yeast cell wall that can be obtained from side streams generated during the fermentation process, have gained increasing attention for their potential as a skin ingredient. Therefore, this…
View article: Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients
Age-Related Changes in Clinical and Analytical Variables in Chronic Hemodialyzed Patients Open
Worldwide, the number of elderly individuals receiving chronic hemodialysis is rising. The aim of our study was to evaluate several clinical and analytical biomarkers in chronically dialyzed patients and analyze how they change with age. A…
View article: Anti-Aging Potential of a Novel Ingredient Derived from Sugarcane Straw Extract (SSE)
Anti-Aging Potential of a Novel Ingredient Derived from Sugarcane Straw Extract (SSE) Open
Natural and sustainable anti-aging ingredients have gained attention from the cosmetic industry. This study evaluated the anti-aging potential of a sugarcane straw extract-based (SSE) cosmetic ingredient. First, cytotoxicity tests were ass…
View article: Biological Potential and Bioaccessibility of Encapsulated Curcumin into Cetyltrimethylammonium Bromide Modified Cellulose Nanocrystals
Biological Potential and Bioaccessibility of Encapsulated Curcumin into Cetyltrimethylammonium Bromide Modified Cellulose Nanocrystals Open
Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been high…
View article: Abdominal Wall Hernias in Peritoneal Dialysis Patients: Risk Factors and Technique Survival
Abdominal Wall Hernias in Peritoneal Dialysis Patients: Risk Factors and Technique Survival Open
Introduction: Peritoneal dialysis patients are at increased risk of developing abdominal wall complications, including hernias. This study aimed to determine the incidence of hernias in peritoneal dialysis patients, identify risk factors, …
View article: Epidemiology of congenital syphilis in Brazil: a retrospective study
Epidemiology of congenital syphilis in Brazil: a retrospective study Open
Congenital syphilis (CS) is an infectious disease transmitted by the bacterium Treponema Pallidum, transplacentally or by contact of the newborn with maternal lesions during delivery. This study aimed to analyze the epidemiological aspects…
View article: #3866 PREOPERATIVE ASSESSMENT FOR VASCULAR ACCESS: VASCULAR MAPPING AND HANDGRIP STRENGTH
#3866 PREOPERATIVE ASSESSMENT FOR VASCULAR ACCESS: VASCULAR MAPPING AND HANDGRIP STRENGTH Open
Background and Aims A reliable vascular access (VA) is required for patients receiving chronic hemodialysis (HD) treatment. VA choice is complex and must consider patient characteristics, predicted patency and risk of primary failure. Vasc…
View article: #6167 THERAPEUTIC PLASMA EXCHANGE AS A TOOL IN THE TREATMENT OF NEUROLOGICAL DISEASES: A SINGLE CENTER EXPERIENCE
#6167 THERAPEUTIC PLASMA EXCHANGE AS A TOOL IN THE TREATMENT OF NEUROLOGICAL DISEASES: A SINGLE CENTER EXPERIENCE Open
Background and Aims Plasmapheresis is an extracorporeal technique that removes immunological active substances, such as antibodies or immune complexes, from plasma. Simultaneously, it can provide essential factors in deficit, when suppleme…
View article: #4713 TUMOR NECROSIS FACTOR RECEPTOR 2 POLYMORPHISM (RS1061622) AND INFLAMMATORY RESPONSE IN END-STAGE RENAL DISEASE PATIENTS UNDER DIALYSIS
#4713 TUMOR NECROSIS FACTOR RECEPTOR 2 POLYMORPHISM (RS1061622) AND INFLAMMATORY RESPONSE IN END-STAGE RENAL DISEASE PATIENTS UNDER DIALYSIS Open
Background and Aims Enhanced levels of soluble tumor necrosis factor receptor 2 (sTNFR2) are known to associate with progressive chronic kidney disease (CKD), and is pointed as a potential biomarker for early detection of CKD; moreover, it…
View article: #6717 IS PERITONEAL DIALYSIS RELATED PERITONITIS A MAJOR RISK FACTOR FOR CARDIOVASCULAR EVENTS?
#6717 IS PERITONEAL DIALYSIS RELATED PERITONITIS A MAJOR RISK FACTOR FOR CARDIOVASCULAR EVENTS? Open
Background and Aims Cardiovascular (CV) disease remains the leading cause of death in peritoneal dialysis (PD) patients and traditional CV risk factors are unable to fully account for this high incidence. The aim of our study was to establ…
View article: The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis
The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis Open
Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers…
View article: Design of Innovative Biocompatible Cellulose Nanostructures for the Delivery and Sustained Release of Curcumin
Design of Innovative Biocompatible Cellulose Nanostructures for the Delivery and Sustained Release of Curcumin Open
Poor aqueous solubility, stability and bioavailability of interesting bioactive compounds is a challenge in the development of bioactive formulations. Cellulose nanostructures are promising and sustainable carriers with unique features tha…
View article: Skincare Potential of a Sustainable Postbiotic Extract Produced Through Sugarcane Straw Fermentation by Saccharomyces Cerevisiae
Skincare Potential of a Sustainable Postbiotic Extract Produced Through Sugarcane Straw Fermentation by Saccharomyces Cerevisiae Open
Postbiotics, a new class of molecules derived from microorganism’s metabolism, are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. They can be produced by fermentati…
View article: Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota
Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota Open
Cannabidiol (CBD) and cannabigerol (CBG) are two pharmacologically active phytocannabinoids of Cannabis sativa L. Their antimicrobial activity needs further elucidation, particularly for CBG, as reports on this cannabinoid are scarce. We i…
View article: Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies
Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies Open
The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from Cannabis sativa, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has beco…
View article: Encapsulating peritoneal sclerosis: from early diagnosis to successful kidney transplantation
Encapsulating peritoneal sclerosis: from early diagnosis to successful kidney transplantation Open
Encapsulating peritoneal sclerosis is an uncommon but serious complication of peritoneal dialysis. In most cases, the symptoms appear after peritoneal dialysis withdrawal, which hampers its diagnosis. We present the case of a 44-years-old …
View article: Metabolic syndrome and cardiovascular disease risk in end-stage renal disease patients
Metabolic syndrome and cardiovascular disease risk in end-stage renal disease patients Open