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View article: Peer Review Journal of Integrated Research Articles: The Impact of Trust and Perception of Type II Diabetes Mellitus Patients on Disease Control Compliance and Nutritional Status of Adolescents in the Family Environment.
Peer Review Journal of Integrated Research Articles: The Impact of Trust and Perception of Type II Diabetes Mellitus Patients on Disease Control Compliance and Nutritional Status of Adolescents in the Family Environment. Open
This study comprehensively examines the relationship between various aspects of beliefs and perceptions of Type II Diabetes Mellitus (T2DM) patients on disease control adherence, as well as its impact on adolescents' nutritional status and…
View article: Non-invasive bladder cancer detection: Identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning
Non-invasive bladder cancer detection: Identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning Open
Early detection of bladder cancer (BC) remains a major clinical challenge due to the limitations of current diagnostic methods, which are often invasive, expensive, or insufficiently sensitive, particularly for early-stage disease. Metabol…
View article: Neurodevelopment in the transition to school in children subjected to hypothermia due to neonatal hypoxic-ischemic encephalopathy: A prospective study
Neurodevelopment in the transition to school in children subjected to hypothermia due to neonatal hypoxic-ischemic encephalopathy: A prospective study Open
Long-term follow-up is essential, even for children with normative early neurodevelopment. Neonatal MRI has strong prognostic value in distinguishing disability from no disability but is less effective in mild impairment prediction.
View article: BugBook: Determining multiple stressor interactions in mass-reared insects based on principles of ecotoxicology
BugBook: Determining multiple stressor interactions in mass-reared insects based on principles of ecotoxicology Open
Insect mass-rearing is a rapidly expanding industry for the production of protein for food and feed. These highly productive artificial rearing environments can expose insects to a range of biotic and abiotic stressors, including insect pa…
View article: Molecular landscape of therapeutic deep eutectic systems selective toxicity towards colorectal cancer
Molecular landscape of therapeutic deep eutectic systems selective toxicity towards colorectal cancer Open
Funding Information: This work has received funding from the ERC-2016-CoG 725034 and was supported by the Associate Laboratory for Green Chemistry (LAQV) financed by national funds from FCT/MCTES (UIDP/50006/2020 DOI 10.54499/UIDP/50006/20…
View article: ANÁLISE EPIDEMIOLÓGICA DE ÓBITOS POR HEPATITE B NO BRASIL ENTRE 2014 E 2024
ANÁLISE EPIDEMIOLÓGICA DE ÓBITOS POR HEPATITE B NO BRASIL ENTRE 2014 E 2024 Open
A hepatite B é uma doença infecciosa que agride o fígado e é classificada como uma infecção sexualmente transmissível. A transmissão ocorre pela exposição ao sangue infectado e secreções corporais. Atualmente, a principal via de transmissã…
View article: Diagnóstico situacional de uma equipe de saúde da família em município de tríplice fronteira
Diagnóstico situacional de uma equipe de saúde da família em município de tríplice fronteira Open
O diagnóstico situacional é essencial para identificar necessidades e direcionar ações de saúde eficazes com base nas condições locais. O presente estudo tem por objetivo realizar o diagnóstico situacional da área de uma Unidade de Saúde d…
View article: Mediterranean Diet-Based Sustainable Healthy Diet and Multicomponent Training Combined Intervention Effect on Body Composition, Anthropometry, and Physical Fitness in Healthy Aging
Mediterranean Diet-Based Sustainable Healthy Diet and Multicomponent Training Combined Intervention Effect on Body Composition, Anthropometry, and Physical Fitness in Healthy Aging Open
Background: Diet and exercise interventions have been associated with improved body composition and physical fitness. However, evidence regarding their combined effects in older adults is scarce. This study aimed to investigate the impact …
View article: Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults
Combined mediterranean diet-based sustainable healthy diet and multicomponent training intervention impact on plasma biomarkers and metabolome in older adults Open
View article: Aortoesophageal Fistula Mimicking Dieulafoy Disease: A Case Report
Aortoesophageal Fistula Mimicking Dieulafoy Disease: A Case Report Open
Introduction: Aortoesophageal fistula (AEF) is a rare and potentially fatal cause of upper gastrointestinal bleeding. The classic Chiari’s triad of symptoms and typical endoscopic findings are not present in all patients, mak…
View article: Impact of the redox-active MnTnHex-2-PyP5+ and cisplatin on the metabolome of non-small cell lung cancer cells
Impact of the redox-active MnTnHex-2-PyP5+ and cisplatin on the metabolome of non-small cell lung cancer cells Open
Redox-based cancer therapeutic strategies aim to raise reactive oxygen species (ROS) levels in cancer cells, thus modifying their redox status, and eventually inducing cell death. Promising compounds, known as superoxide dismutase mimics (…
View article: The InBIO Barcoding Initiative Database: DNA barcodes of Portuguese moths
The InBIO Barcoding Initiative Database: DNA barcodes of Portuguese moths Open
The InBIO Barcoding Initiative (IBI) Dataset - DS-IBILP08 contains records of 2350 specimens of moths (Lepidoptera species that do not belong to the superfamily Papilionoidea). All specimens have been morphologically identified to species …
View article: Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect
Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect Open
Advanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidate…
View article: Molecular landscape of THEDES selective toxicity towards colorectal cancer
Molecular landscape of THEDES selective toxicity towards colorectal cancer Open
In the relentless pursuit of overcoming modern medicine most highly demanding challenges, such as the most incident and deadliest cancers, as colon and rectum cancer (CRC), we keep on seeking innovative therapeutic solutions. Following dee…
View article: Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS
Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of motor neurons leads to loss of muscle function. Additionally, cognitive and circadian disruptions are common in ALS patients, contributing to disease …
View article: STEM CELL SOLUTION TO GAD65 ANTIBODIES INDUCED HURRICANE OF TYPE 1 DIABETES AND NEUROLOGICAL DISORDERS
STEM CELL SOLUTION TO GAD65 ANTIBODIES INDUCED HURRICANE OF TYPE 1 DIABETES AND NEUROLOGICAL DISORDERS Open
The encounter of disorders associated with antibodies to neuronal enzymes caused a paradigm shift in understanding the CNS autoimmunity.The autoimmune disorders targeting the 65kDa isoform of glutamic acid decarboxylase (GAD65) not only co…
View article: Metabolomics perspectives of the ecotoxicological risks of polycyclic aromatic hydrocarbons: A scoping review
Metabolomics perspectives of the ecotoxicological risks of polycyclic aromatic hydrocarbons: A scoping review Open
Polycyclic Aromatic Hydrocarbons (PAHs) represent persistent environmental pollutants ubiquitously distributed in the environment. Their presence alongside various other contaminants gives rise to intricate interactions, culminating in pro…
View article: Bilateral lumbosacral plexopathy: A rare condition presenting as a diagnostic challenge
Bilateral lumbosacral plexopathy: A rare condition presenting as a diagnostic challenge Open
Lumbosacral plexopathy (LP) is an uncommon condition. Its diagnosis may be challenging especially in the absence of evident structural causes and should be supported by lumbosacral imaging and neurophysiologic studies. LP is considered idi…
View article: Metabolomic Signatures of Treatment Response in Bladder Cancer
Metabolomic Signatures of Treatment Response in Bladder Cancer Open
Bladder cancer (BC) stands as one of the most prevalent urological malignancies, with over 500 thousand newly diagnosed cases annually. Treatment decisions in BC depend on factors like the risk of recurrence, the type of tumor, and the sta…
View article: Unmasking Hidden Systemic Effects of Neurodegenerative Diseases: A Two-Pronged Approach to Biomarker Discovery
Unmasking Hidden Systemic Effects of Neurodegenerative Diseases: A Two-Pronged Approach to Biomarker Discovery Open
Identification of reliable blood biomarkers for neurodegenerative diseases (NDs) is crucial for translational and clinical research. However, conventional omics struggle with blood samples complexity, hindering desired outcomes. In this wo…
View article: Clinical Worsening of Charcot-Marie-Tooth Disease Due to Overlapping Acute Inflammatory Polyneuropathy
Clinical Worsening of Charcot-Marie-Tooth Disease Due to Overlapping Acute Inflammatory Polyneuropathy Open
View article: Reversible Bilateral Basal Ganglia Lesions Due to Multifactorial Toxic-Metabolic Disorders
Reversible Bilateral Basal Ganglia Lesions Due to Multifactorial Toxic-Metabolic Disorders Open
Bilateral basal ganglia lesions can include a wide variety of etiologies, including metabolic, toxic, degenerative, vascular, inflammatory, infectious, and neoplastic etiology. We present a case of a 78-year-old man who was hospitalized wi…
View article: Advances in Metabolic Profiling of Biological Samples
Advances in Metabolic Profiling of Biological Samples Open
Metabolomics constitutes a promising approach to clinical diagnostics, but its practical implementation in clinical settings is hindered by the requirement for rapid and efficient analytical methods [...]
View article: Multidimensional Health Impact of Multicomponent Exercise and Sustainable Healthy Diet Interventions in the Elderly (MED-E): Study Protocol
Multidimensional Health Impact of Multicomponent Exercise and Sustainable Healthy Diet Interventions in the Elderly (MED-E): Study Protocol Open
Data concerning the combined effect of diet and exercise interventions on overall health in the elderly are scarce. The MED-E project’s primary aim is to assess the effect of the different 3-month sustainable healthy diet (SHD) and multico…
View article: The InBIO barcoding initiative database: DNA barcodes of Iberian Trichoptera, documenting biodiversity for freshwater biomonitoring in a Mediterranean hotspot
The InBIO barcoding initiative database: DNA barcodes of Iberian Trichoptera, documenting biodiversity for freshwater biomonitoring in a Mediterranean hotspot Open
The Trichoptera are an important component of freshwater ecosystems. In the Iberian Peninsula, 380 taxa of caddisflies are known, with nearly 1/3 of the total species being endemic in the region. A reference collection of morphologically id…
View article: MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
MnTnHex-2-PyP5+ Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells Open
The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. N…
View article: Sunitinib versus Pazopanib Dilemma in Renal Cell Carcinoma: New Insights into the In Vitro Metabolic Impact, Efficacy, and Safety
Sunitinib versus Pazopanib Dilemma in Renal Cell Carcinoma: New Insights into the In Vitro Metabolic Impact, Efficacy, and Safety Open
Sunitinib and pazopanib are tyrosine kinase inhibitors (TKIs) used as first-line therapy for metastatic renal cell carcinoma (RCC). Although these TKIs are associated with similar survival outcomes, some differences have been reported in t…
View article: Differential cellular effects of sunitinib and pazopanib targeted drugs for metastatic renal cell carcinoma: an in vitro approach
Differential cellular effects of sunitinib and pazopanib targeted drugs for metastatic renal cell carcinoma: an in vitro approach Open
View article: Impact of benzo[a]pyrene, phenanthrene, and their mixtures on the matebolome of hepatocytes isolated from fish
Impact of benzo[a]pyrene, phenanthrene, and their mixtures on the matebolome of hepatocytes isolated from fish Open
View article: Primary Progressive Multiple Sclerosis in a Portuguese Patient With Neurofibromatosis Type 1
Primary Progressive Multiple Sclerosis in a Portuguese Patient With Neurofibromatosis Type 1 Open
Neurofibromatosis type 1 (NF1) is a frequent genetic neurocutaneous syndrome and multiple sclerosis (MS) is an acquired demyelinating disease of the central nervous system. The association of both these diseases is rare. In this case repor…