Jocelyn G. Olvera
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View article: NanoNERF: A nanoscale NERF blaster replica made of DNA
NanoNERF: A nanoscale NERF blaster replica made of DNA Open
We used DNA origami to create NanoNERF, the world’s smallest NERF blaster replica (Figure 1). We based our design on the NERF model Maverick Rev-6 , and scaled the dimensions down three million times. NanoNERF is planar and measures ∼100 n…
View article: Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications
Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications Open
Background Ulcerative colitis (UC) and Crohn’s disease are 2 types of inflammatory bowel disease (IBD), a group of chronic digestive disorders caused by aberrant immune responses to intestinal microbes. Although changes in the composition …
View article: Identification of CD8+ T-Cell–Immune Cell Communications in Ileal Crohn's Disease
Identification of CD8+ T-Cell–Immune Cell Communications in Ileal Crohn's Disease Open
INTRODUCTION: Crohn's disease (CD) is a major subtype of inflammatory bowel disease (IBD), a spectrum of chronic intestinal disorders caused by dysregulated immune responses to gut microbiota. Although transcriptional and functional change…
View article: Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes Open
Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling infection. TRM cells exhibit differences across tissues, but their potential heterogeneity…
View article: Skin inflammation activates intestinal stromal fibroblasts and promotes colitis
Skin inflammation activates intestinal stromal fibroblasts and promotes colitis Open
Inflammatory disorders of the skin are frequently associated with inflammatory bowel diseases (IBDs). To explore mechanisms by which these organs communicate, we performed single-cell RNA-Seq analysis on fibroblasts from humans and mice wi…
View article: Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses
Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses Open
Single-cell sequencing analyses reveal changes in B and T cell transcriptional states in the context of ulcerative colitis.
View article: Early precursors and molecular determinants of tissue-resident memory CD8 <sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing
Early precursors and molecular determinants of tissue-resident memory CD8 <sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing Open
Heterogeneity of small intestine intraepithelial CD8 + T cells suggests functionally distinct subsets of T RM cells and their precursors.
View article: Molecular determinants and heterogeneity of tissue-resident memory CD8<sup>+</sup>T lymphocytes revealed by single-cell RNA sequencing
Molecular determinants and heterogeneity of tissue-resident memory CD8<sup>+</sup>T lymphocytes revealed by single-cell RNA sequencing Open
During an immune response to microbial infection, CD8 + T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subs…
View article: Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance
Integrin Activation Controls Regulatory T Cell–Mediated Peripheral Tolerance Open
Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-ext…
View article: Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification
Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification Open
During an immune response, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt terminal effector and memory cell fates. Here we show that "pre-effector" and "pre-memor…
View article: Nitrate-Regulated Glutaredoxins Control Arabidopsis Primary Root Growth
Nitrate-Regulated Glutaredoxins Control Arabidopsis Primary Root Growth Open
Nitrogen is an essential soil nutrient for plants, and lack of nitrogen commonly limits plant growth. Soil nitrogen is typically available to plants in two inorganic forms: nitrate and ammonium. To better understand how nitrate and ammoniu…