Jochem Struppe
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View article: “Solid-in-Solid” Electrolyte via Scalable Melting Infiltration Method for High-Voltage Solid-State Lithium Metal Batteries
“Solid-in-Solid” Electrolyte via Scalable Melting Infiltration Method for High-Voltage Solid-State Lithium Metal Batteries Open
Solid electrolytes are critical to enabling safe and high-energy-density batteries; yet, their practical deployment is impeded by poor electrochemical stability, inadequate interfacial contact, and challenging manufacturing processes. Here…
View article: Alkali Treatment Implications for Microwave-Assisted Rare Earth Elements Extraction from Coal Mine Tailings
Alkali Treatment Implications for Microwave-Assisted Rare Earth Elements Extraction from Coal Mine Tailings Open
Coal tailings represent a promising secondary resource of rare earth elements (REEs), yet efficient extraction is limited by their complex mineralogy. This study investigated the impact of alkali pretreatment on aluminosilicate structures …
View article: MAS Cryoprobe Enhances Solid-State NMR Signals of α-Synuclein Fibrils
MAS Cryoprobe Enhances Solid-State NMR Signals of α-Synuclein Fibrils Open
Solid-state NMR spectroscopy is increasingly applied to structural and dynamics studies across a broad range of chemical, material, and biological systems. Although sensitivity has traditionally been a major limitation, the recently develo…
View article: “Solid-in-Solid” Electrolyte via Scalable Melting Infiltration Method for High-Voltage Solid-State Lithium Metal Batteries
“Solid-in-Solid” Electrolyte via Scalable Melting Infiltration Method for High-Voltage Solid-State Lithium Metal Batteries Open
Solid electrolytes are critical to enabling safe and high-energy-density batteries, yet their practical deployment is impeded by poor electrochemical stability, inadequate interfacial contact, and challenging manufacturing processes. Here,…
View article: Alkali Treatment Implications for Microwave-assisted Rare Earth Elements Extraction from Coal Mine Tailings
Alkali Treatment Implications for Microwave-assisted Rare Earth Elements Extraction from Coal Mine Tailings Open
Coal tailings represent a promising secondary resource of rare earth elements (REEs), yet efficient extraction remains a challenge due to their complex mineralogy. In this study, we investigated the impact of alkali pretreatment on alumino…
View article: Structural Model of Bacteriophage P22 Scaffolding Protein in a Procapsid by Magic-Angle Spinning NMR
Structural Model of Bacteriophage P22 Scaffolding Protein in a Procapsid by Magic-Angle Spinning NMR Open
Icosahedral dsDNA viruses such as the tailed bacteriophages and herpesviruses have a conserved pathway to virion assembly that is initiated from a scaffolding protein driven procapsid formation. The dsDNA is actively packaged into procapsi…
View article: Integrating <sup>19</sup>F Distance Restraints for Accurate Protein Structure Determination by Magic Angle Spinning NMR Spectroscopy
Integrating <sup>19</sup>F Distance Restraints for Accurate Protein Structure Determination by Magic Angle Spinning NMR Spectroscopy Open
Traditional protein structure determination by magic angle spinning (MAS) solid-state NMR spectroscopy primarily relies on interatomic distances up to 8 Å, extracted from 13C-, 15N-, and 1H-based dipolar-ba…
View article: Nanodisc reconstitution and characterization of amyloid-β precursor protein C99
Nanodisc reconstitution and characterization of amyloid-β precursor protein C99 Open
Amyloid precursor protein (APP) plays a pivotal role in the pathology of Alzheimer’s disease. Since the fragmentation of the membrane-bound APP that results in the production of amyloid-beta peptides is the starting point for amyloid toxic…
View article: Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite
Solid-state NMR MAS CryoProbe enables structural studies of human blood protein vitronectin bound to hydroxyapatite Open
View article: Overcoming challenges in <sup>67</sup>Zn NMR: a new strategy of signal enhancement for MOF characterization
Overcoming challenges in <sup>67</sup>Zn NMR: a new strategy of signal enhancement for MOF characterization Open
Combining a cryogenic MAS probe and high magnetic field results in remarkable signal enhancement, permitting MOF characterization by 67 Zn 3QMAS NMR at natural abundance.
View article: 19F fast MAS (60–111 kHz) dipolar and scalar based correlation spectroscopy of organic molecules and pharmaceutical formulations
19F fast MAS (60–111 kHz) dipolar and scalar based correlation spectroscopy of organic molecules and pharmaceutical formulations Open
View article: Determination of accurate 19F chemical shift tensors with R-symmetry recoupling at high MAS frequencies (60–100 kHz)
Determination of accurate 19F chemical shift tensors with R-symmetry recoupling at high MAS frequencies (60–100 kHz) Open
View article: Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate Open
Significance The determination of active site protonation states is critical for a full mechanistic understanding of enzymatic transformations. However, hydrogen atom positions are challenging to extract using the standard tools of structu…
View article: Solid-state <sup>17</sup>O NMR study of α-<scp>d</scp>-glucose: exploring new frontiers in isotopic labeling, sensitivity enhancement, and NMR crystallography
Solid-state <sup>17</sup>O NMR study of α-<span>d</span>-glucose: exploring new frontiers in isotopic labeling, sensitivity enhancement, and NMR crystallography Open
We report the first “total synthesis” of 17 O-labeled d -glucose and its solid-state 17 O NMR characterization with unprecedented sensitivity and resolution.
View article: Fast <sup>19</sup>F Magic-Angle Spinning Nuclear Magnetic Resonance for the Structural Characterization of Active Pharmaceutical Ingredients in Blockbuster Drugs
Fast <sup>19</sup>F Magic-Angle Spinning Nuclear Magnetic Resonance for the Structural Characterization of Active Pharmaceutical Ingredients in Blockbuster Drugs Open
Fluorinated drugs occupy a large and growing share of the pharmaceutical market. Here, we explore high-frequency, 60 to 111 kHz, 19F magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy for the structural cha…
View article: Fast <sup>19</sup>F Magic Angle Spinning NMR Crystallography for Structural Characterization of Fluorine-Containing Pharmaceutical Compounds
Fast <sup>19</sup>F Magic Angle Spinning NMR Crystallography for Structural Characterization of Fluorine-Containing Pharmaceutical Compounds Open
Fluorine-containing compounds comprise 20 to 30 percent of all commercial drugs, and the proportion of fluorinated pharmaceuticals is rapidly growing. While magic angle spinning (MAS) NMR spectroscopy is a popular technique for analysis of…
View article: Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate
Imaging active site chemistry and protonation states: NMR crystallography of the tryptophan synthase α-aminoacrylate intermediate Open
NMR-assisted crystallography – the synergistic combination of solid-state NMR, X-ray crystallography, and first-principles computational chemistry – holds remarkable promise for mechanistic enzymology: by providing atomic-resolution charac…
View article: Competing transfer pathways in direct and indirect dynamic nuclear polarization magic anglespinning nuclear magnetic resonance experiments on HIV-1 capsid assemblies: implications for sensitivity and resolution
Competing transfer pathways in direct and indirect dynamic nuclear polarization magic anglespinning nuclear magnetic resonance experiments on HIV-1 capsid assemblies: implications for sensitivity and resolution Open
Dynamic nuclear polarization (DNP)-enhanced magic angle spinning (MAS) nuclear magnetic resonance (NMR) of biological systems is a rapidly growing field. Large signal enhancements make the technique particularly attractive for signal-limit…
View article: Comment on mr-2021-13
Comment on mr-2021-13 Open
Abstract. Dynamic nuclear polarization (DNP)-enhanced magic angle spinning (MAS) nuclear magnetic resonance (NMR) of biological systems is a rapidly growing field. Large signal enhancements make the technique particularly …
View article: Competing Transfer Pathways in Direct and Indirect DynamicNuclear Polarization MAS NMR Experiments on HIV-1 CapsidAssemblies: Implications for Sensitivity and Resolution
Competing Transfer Pathways in Direct and Indirect DynamicNuclear Polarization MAS NMR Experiments on HIV-1 CapsidAssemblies: Implications for Sensitivity and Resolution Open
Dynamic nuclear polarization-enhanced (DNP) magic angle spinning (MAS) NMR of biological systems is a rapidly growing field. Large signal enhancements make the technique particularly attractive for signal-limited cases, such as studies of …
View article: Supplementary material to "Competing Transfer Pathways in Direct and Indirect DynamicNuclear Polarization MAS NMR Experiments on HIV-1 CapsidAssemblies: Implications for Sensitivity and Resolution"
Supplementary material to "Competing Transfer Pathways in Direct and Indirect DynamicNuclear Polarization MAS NMR Experiments on HIV-1 CapsidAssemblies: Implications for Sensitivity and Resolution" Open
View article: Ex vivo Comprehensive Multiphase NMR of whole organisms: A complementary tool to in vivo NMR
Ex vivo Comprehensive Multiphase NMR of whole organisms: A complementary tool to in vivo NMR Open
Nuclear Magnetic Resonance (NMR) spectroscopy is a non-invasive analytical technique which allows for the study of intact samples. Comprehensive Multiphase NMR (CMP-NMR) combines techniques and hardware from solution state and solid state …
View article: Ultrafast <sup>1</sup>H MAS NMR Crystallography for Natural Abundance Pharmaceutical Compounds
Ultrafast <sup>1</sup>H MAS NMR Crystallography for Natural Abundance Pharmaceutical Compounds Open
Magic angle spinning (MAS) NMR is a powerful method for the study of pharmaceutical compounds, and probes with spinning frequencies above 100 kHz enable an atomic-resolution analysis of sub-micromole quantities of fully protonated solids. …
View article: Sensitivity boosts by the CPMAS CryoProbe for challenging biological assemblies
Sensitivity boosts by the CPMAS CryoProbe for challenging biological assemblies Open
View article: CCDC 1953545: Experimental Crystal Structure Determination
CCDC 1953545: Experimental Crystal Structure Determination Open
View article: CCDC 1953345: Experimental Crystal Structure Determination
CCDC 1953345: Experimental Crystal Structure Determination Open
View article: Measurement of Accurate Interfluorine Distances in Crystalline Organic Solids: A High-Frequency Magic Angle Spinning NMR Approach
Measurement of Accurate Interfluorine Distances in Crystalline Organic Solids: A High-Frequency Magic Angle Spinning NMR Approach Open
Long-range interatomic distance restraints are critical for the determination of molecular structures by NMR spectroscopy, both in solution and in the solid state. Fluorine is a powerful NMR probe in a wide variety of contexts, owing to it…
View article: Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies
Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies Open
We report dynamic nuclear polarization (DNP)-enhanced magic-angle spinning (MAS) NMR spectroscopy in viral capsids from HIV-1 and bacteriophage AP205. Viruses regulate their life cycles and infectivity through modulation of their structure…
View article: Carbon-nitrogen REDOR to identify ms-timescale mobility in proteins
Carbon-nitrogen REDOR to identify ms-timescale mobility in proteins Open
View article: <sup>19</sup>F Dynamic Nuclear Polarization at Fast Magic Angle Spinning for NMR of HIV-1 Capsid Protein Assemblies
<sup>19</sup>F Dynamic Nuclear Polarization at Fast Magic Angle Spinning for NMR of HIV-1 Capsid Protein Assemblies Open
We report remarkably high, up to 100-fold, signal enhancements in 19F dynamic nuclear polarization (DNP) magic angle spinning (MAS) spectra at 14.1 T on HIV-1 capsid protein (CA) assemblies. These enhancements correspond to abso…