Jochen Behrends
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View article: High-Purity Enrichment of Extracellular Vesicles from Diverse Sources by Conventional and Image-Based Fluorescence Activated Cell Sorters for Robust Downstream Applications
High-Purity Enrichment of Extracellular Vesicles from Diverse Sources by Conventional and Image-Based Fluorescence Activated Cell Sorters for Robust Downstream Applications Open
Separating and enriching specific extracellular vesicle (EV) subpopulations from the broader EV pool present in tissues and blood is crucial for understanding their role in physiological and pathological conditions. However, high-purity en…
View article: Sex Differences in Vaccine-Induced Immunity and Protection Against <i>Mycobacterium tuberculosis</i>
Sex Differences in Vaccine-Induced Immunity and Protection Against <i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) remains a leading global cause of death, with approximately 1.3 million fatalities annually. While males are more susceptible to TB, the underlying immune differences and their impact on vaccine efficacy are not fully und…
View article: Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium Open
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. These bacteria adopt diverse morphologies, yet the molecular basis of their morphological…
View article: SMAD2 linker phosphorylation impacts overall survival, proliferation, TGFβ1-dependent gene expression and pluripotency-related proteins in NSCLC
SMAD2 linker phosphorylation impacts overall survival, proliferation, TGFβ1-dependent gene expression and pluripotency-related proteins in NSCLC Open
Background We investigated the impact of SMAD2 linker phosphorylation (pSMAD2L) on overall and disease-free survival, signal transduction, as well as cancer-related processes in non-small cell lung cancer (NSCLC). Methods We generated A549…
View article: Sex-specific impact of B cell-derived IL-10 on tuberculosis resistance
Sex-specific impact of B cell-derived IL-10 on tuberculosis resistance Open
Introduction Due to the historical dogma that host defense against intracellular pathogens is primarily mediated by cell-mediated immunity, B cells have long been considered unimportant in providing protection against Mycobacterium tubercu…
View article: Neutrophils negatively control IL-17A-producing γδ T cell frequencies in a contact-dependent manner under physiological conditions
Neutrophils negatively control IL-17A-producing γδ T cell frequencies in a contact-dependent manner under physiological conditions Open
Background In addition to serving as the primary effector cells against infections, neutrophils have been implicated in the regulation of both innate and adaptive immunity. In this study, we aimed to investigate the role of neutrophils in …
View article: Sex differences in vaccine induced immunity and protection against<i>Mycobacterium tuberculosis</i>
Sex differences in vaccine induced immunity and protection against<i>Mycobacterium tuberculosis</i> Open
Tuberculosis (TB) is a disease that has evolved with humankind for millennia, causing approximately 1.3 million deaths worldwide per annum. Although increased male affliction for TB and other infections were long known from an epidemiologi…
View article: Antiviral CD8<sup>+</sup>T-cell immune responses are impaired by cigarette smoke and in COPD
Antiviral CD8<sup>+</sup>T-cell immune responses are impaired by cigarette smoke and in COPD Open
Background Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 + T-cells by viral epitopes presented on major histocompatibility complex (MHC) class I molecules of i…
View article: Lipid transfer protein syndrome in a Northern European patient: An unusual case report
Lipid transfer protein syndrome in a Northern European patient: An unusual case report Open
Non-specific lipid transfer proteins (nsLTPs) as the primary sensitizer in plant-food allergic patients used to be seen primarily in the Mediterranean area. However, more recently, increasing numbers of clinically relevant sensitizations a…
View article: Sialylation of <scp>IgE</scp> reduces <scp>FcεRIα</scp> interaction and mast cell and basophil activation in vitro and increases <scp>IgE</scp> half‐life in vivo
Sialylation of <span>IgE</span> reduces <span>FcεRIα</span> interaction and mast cell and basophil activation in vitro and increases <span>IgE</span> half‐life in vivo Open
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View article: High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice
High-Dose Mycobacterium tuberculosis H37rv Infection in IL-17A- and IL-17A/F-Deficient Mice Open
During experimental tuberculosis (TB), interleukin (IL)-17A appears to be involved in the formation of lung granulomas, possibly through the attraction of neutrophils to the sites of infection. However, the protective impact of cytokine ap…
View article: Table of Contents
Table of Contents Open
View article: CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression Open
View article: Correction to: Interleukin‑23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin‑17A
Correction to: Interleukin‑23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin‑17A Open
View article: Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life Open
View article: Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A
Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A Open
View article: WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis Open
In view of emerging drug-resistant tuberculosis (TB), host-directed adjunct therapies are urgently needed to improve treatment outcomes with currently available anti-TB therapies. One approach is to interfere with the formation of lipid-la…
View article: Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation
Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation Open
Background Allergy is one of the most common chronic diseases in Europe. Therefore, an increased need for specific and sensitive diagnostic tests that truly detect allergy exists. This study aimed at establishing a highly specific high‐thr…
View article: Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex
Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex Open
View article: IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv
IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv Open
Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-in…
View article: BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice
BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice Open
Clinical and experimental evidence suggests that the tuberculosis vaccine BCG offers protection against unrelated pathogens including the malaria parasite. Cerebral malaria (CM) is the most severe complication associated with Plasmodium fa…
View article: RNA‐seq–based profiling of extracellular vesicles in plasma reveals a potential role of miR‐122‐5p in asthma
RNA‐seq–based profiling of extracellular vesicles in plasma reveals a potential role of miR‐122‐5p in asthma Open
To the Editor, Asthma is a heterogeneous disease encompassing several distinct sub-phenotypes with different etiologies and treatment responses,1 but we are lacking markers to differentiate patient subgroups. MicroRNAs (miRNAs) can regulat…
View article: WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by<i>M. tuberculosis</i>
WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by<i>M. tuberculosis</i> Open
In view of emerging drug-resistant tuberculosis, host directed therapies are urgently needed to improve treatment outcomes with currently available anti-tuberculosis therapies. One option is to interfere with the formation of lipid-laden “…
View article: Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides
Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides Open
View article: Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development
Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development Open
Background miRNAs are master regulators of signaling pathways critically involved in asthma and are transferred between cells in extracellular vesicles (EV). We aimed to investigate whether the miRNA content of EV secreted by primary norma…
View article: Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy
Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy Open
Cow’s milk allergy (CMA) belongs to one of the most common food allergies in early childhood affecting 2–3% of children under 3 years of age. However, approximately 1% of adults remain allergic to cow’s milk, often showing severe reactions…
View article: Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation
Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation Open
Epidemiological findings indicate that coinfection with influenza viruses is associated with an increased risk of death in patients suffering from tuberculosis but the underlying pathomechanisms are not well understood. In this study, we d…
View article: Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane‐bound and free toxins
Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane‐bound and free toxins Open
Increasing failure of conventional antibiotics to combat bacterial infections requires the urgent development of new antibacterial drugs; a promising class of new drugs based on antimicrobial peptides. Here, we studied the molecular intera…
View article: The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells
The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells Open
View article: De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages Open
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to efficiently manipulate the host immune system establishing chronic infection, yet the underlying mechanisms of immune evasion are not ful…