Explanipedia

Molecular determinants of cesium- and glycine-dependent glycine receptor activation Open

Magnus Harnau, E. A. Zeller, Steffen Fricke, Jochen C. Meier · 2025

The neurotransmitter receptor for glycine (GlyR) is a ligand-gated chloride-permeable ion channel in the central nervous system, and dysregulation of this channel is associated with diverse neurological disorders. Cesium (Cs + ) is an agon…

Role of Family Involvement and Communication Skills in Predicting Social Integration in Children with Autism Open

Tobias Neumann, Jochen C. Meier · 2025

This study aimed to examine the predictive roles of family involvement and communication skills in determining the level of social integration among children with autism. The research utilized a correlational descriptive design with a samp…

Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications Open

Mark Helm, Markus T. Bohnsack, Thomas Carell, Alexander H. Dalpke, Karl‐Dieter Entian , et al. · 2023

The chemical biology of native nucleic acid modifications has seen an intense upswing, first concerning DNA modifications in the field of epigenetics and then concerning RNA modifications in a field that was correspondingly rebaptized epit…

Cesium activates the neurotransmitter receptor for glycine Open

Steffen Fricke, Magnus Harnau, Florian Hetsch, Haoran Liu, Julia Leonhard , et al. · 2023

The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, other monovalent alkali metal ions such as cesium and lithium can also affect neuronal physiology. For instance, there…

Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner Open

Alessandro Dorigo, Komali Valishetti, Florian Hetsch, Hideaki Matsui, Jochen C. Meier , et al. · 2023

Introduction The cerebellum is organized into functional regions each dedicated to process different motor or sensory inputs for controlling different locomotor behaviors. This functional regionalization is prominent in the evolutionary co…

Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish Open

Sol Pose‐Méndez, Paul Schramm, Barbara Winter, Jochen C. Meier, Konstantinos Ampatzis , et al. · 2023

Zebrafish have an impressive capacity to regenerate neurons in the central nervous system. However, regeneration of the principal neuron of the evolutionary conserved cerebellum, the Purkinje cell (PC), is believed to be limited to develop…

Author response: Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish Open

Sol Pose‐Méndez, Paul Schramm, Barbara Winter, Jochen C. Meier, Konstantinos Ampatzis , et al. · 2023

Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants Open

Veerle Lemmens, Bart Thevelein, Yana Vella, Svenja Kankowski, Julia Leonhard , et al. · 2022

Lifelong regeneration of cerebellar Purkinje neurons after induced cell ablation in zebrafish Open

Sol Pose‐Méndez, Paul Schramm, Barbara Winter, Jochen C. Meier, Konstantinos Ampatzis , et al. · 2022

Zebrafish have an impressive capacity to regenerate neurons in the central nervous system. However, regeneration of the principal neuron of the evolutionary conserved cerebellum, the Purkinje cell (PC), is believed to be limited to develop…

Editorial: Spring Hippocampal Research Conference and Beyond Open

James A. Ainge, Mariangela Chisari, Akiva S. Cohen, Steven Mennerick, Lisa Topolnik , et al. · 2021

EDITORIAL article Front. Mol. Neurosci., 12 October 2021 | https://doi.org/10.3389/fnmol.2021.773308

Biallelic gephyrin variants lead to impaired GABAergic inhibition in a patient with developmental and epileptic encephalopathy Open

Arthur Macha, Filip Liebsch, Steffen Fricke, Florian Hetsch, Franziska Neuser , et al. · 2021

Synaptic inhibition is essential for shaping the dynamics of neuronal networks, and aberrant inhibition is linked to epilepsy. Gephyrin (Geph) is the principal scaffolding protein at inhibitory synapses and is essential for postsynaptic cl…

A new triple fluorescence reporter system for discrimination of Apobec1 and Apobec3 C-to-U RNA editing activities and editing-dependent protein expression Open

Barbara Schweissthal, Kea Brunken, Julia Brach, Leon von der Emde, Florian Hetsch , et al. · 2021

The human body is composed of many different cell types which communicate with each other. In particular, the brain consists of billions of neurons and non-neuronal cells which are interconnected and require tight and precise regulation of…

Glycine receptor α3K governs mobility and conductance of L/K splice variant heteropentamers Open

Veerle Lemmens, Bart Thevelein, Svenja Kankowski, Hideaki Mizuno, Jochen C. Meier , et al. · 2021

Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe epilepsy. Alternative splicing into K or L variants determines…

Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro Open

Larissa Kraus, Florian Hetsch, Ulf C. Schneider, Helena Radbruch, Martin Holtkamp , et al. · 2019

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy with about 30% of patients developing pharmacoresistance. These patients continue to suffer from seizures despite polytherapy with antiepileptic drugs (AEDs) and have a…

Corrigendum: A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy Open

Svenja Kankowski, Benjamín Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker , et al. · 2019

[This corrects the article DOI: 10.3389/fnmol.2017.00439.].

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA Open

Yanghao Hou, Jorge Pinheiro, Felix Sahm, David Reuß, Daniel Schrimpf , et al. · 2019

Dimethylethanolamine decreases epileptiform activity in acute human hippocampal slices in vitro Open

Larissa Kraus, Florian Hetsch, Ulf C. Schneider, Helena Radbruch, Martin Holtkamp , et al. · 2019

Human hippocampal tissue from epilepsy surgery was collected from 12 TLE patients (ten male, two female) and cut in the laboratory to 400 µm slices. Field potential recordings were performed with borosilicate pipettes pulled with a vertica…

The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice Open

Annett Boeddrich, Julius T. Babila, Thomas Wiglenda, Lisa Diez, Manuela Jacob , et al. · 2018

RNA Editing and Retrotransposons in Neurology Open

Heinz Krestel, Jochen C. Meier · 2018

Compared to sites in protein-coding sequences many more targets undergoing adenosine to inosine (A-to-I) RNA editing were discovered in non-coding regions of human cerebral transcripts, particularly in genetic transposable elements called …

Imaging pathological activities of human brain tissue in organotypic culture Open

Caroline Le Duigou, Etienne Savary, Mélanie Morin‐Brureau, Daniel Gómez-Domínguez, André Sobczyk , et al. · 2018

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy Open

Svenja Kankowski, Benjamín Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker , et al. · 2018

[This corrects the article DOI: 10.3389/fnmol.2017.00439.].

A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit <i>via</i> FRET in a binary system Open

Ge‐Min Fang, Jasmine Chamiolo, Svenja Kankowski, Felix Hövelmann, Dhana Friedrich , et al. · 2018

Three states in one blow: a FRET relay system distinguishes between (i) the absence of RNA target, (ii) the presence of C → U edited RNA or (iii) unedited RNA target by means of ratio measurements.

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy Open

Borislav Dejanovic, Tania Djémié, Nora Grünewald, Arvid Suls, Vanessa Kress , et al. · 2017

Corrigendum1 December 2017Open Access Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy Borislav Dejanovic Borislav Dejanovic Search for more papers by this author Tan…

S-sulfocysteine/NMDA receptor–dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency Open

Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fuscà , et al. · 2017

Molybdenum cofactor deficiency (MoCD) is an autosomal recessive inborn error of metabolism characterized by neurodegeneration and death in early childhood. The rapid and progressive neurodegeneration in MoCD presents a major clinical chall…

Editorial: Metabolic Control of Brain Homeostasis Open

Detlev Boison, Jochen C. Meier, Susan A. Masino · 2017

EDITORIAL article Front. Mol. Neurosci., 09 June 2017Sec. Brain Disease Mechanisms Volume 10 - 2017 | https://doi.org/10.3389/fnmol.2017.00184

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders Open

Carmen Lorenz, Pierre Lesimple, Raul Bukowiecki, Annika Zink, Gizem Inak , et al. · 2017

RNA Editing—Systemic Relevance and Clue to Disease Mechanisms? Open

Jochen C. Meier, Svenja Kankowski, Heinz Krestel, Florian Hetsch · 2016

Recent advances in sequencing technologies led to the identification of a plethora of different genes and several hundreds of amino acid recoding edited positions. Changes in editing rates of some of these positions were associated with di…

Step-by-step guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy Open

Dominik Schneidereit, Larissa Kraus, Jochen C. Meier, Oliver Friedrich, Daniel F. Gilbert · 2016

High-content screening microscopy relies on automation infrastructure that is typically proprietary, non-customizable, costly and requires a high level of skill to use and maintain. The increasing availability of rapid prototyping technolo…

Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels Open

Constanze Raltschev, Florian Hetsch, Aline Winkelmann, Jochen C. Meier, Marcus Semtner · 2016

Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence Open

Gürsel Çalışkan, Iris Müller, Marcus Semtner, Aline Winkelmann, Ahsan S. Raza , et al. · 2016

Parvalbumin-positive (PV) basket cells provide perisomatic inhibition in the cortex and hippocampus and control generation of memory-related network activity patterns, such as sharp wave ripples (SPW-R). Deterioration of this class of fast…

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