Jochen Kieninger
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View article: Microsensor systems for cell metabolism – from 2D culture to organ-on-chip (2019–2024)
Microsensor systems for cell metabolism – from 2D culture to organ-on-chip (2019–2024) Open
We review the latest developments in microsensor systems for monitoring the metabolism of cell cultures and organs-on-chip, including sensor principles, requirements, performance, notable achievements, and trends in microfabrication.
View article: Reference Electrode Types for Zero‐Gap CO<sub>2</sub> Electrolyzers: Benefits and Limitations
Reference Electrode Types for Zero‐Gap CO<sub>2</sub> Electrolyzers: Benefits and Limitations Open
Integrated reference electrodes allow to deconvolute voltage contributions of anode and cathode and contribute to a better understanding of CO 2 electrolyzers. However, in zero‐gap cell configurations, this integration can be challenging a…
View article: In Situ Performance Monitoring of Electrochemical Oxygen and Hydrogen Peroxide Sensors in an Additively Manufactured Modular Microreactor
In Situ Performance Monitoring of Electrochemical Oxygen and Hydrogen Peroxide Sensors in an Additively Manufactured Modular Microreactor Open
Miniaturized and microstructured reactors in process engineering are essential for a more decentralized, flexible, sustainable, and resilient chemical production. Modern, additive manufacturing methods for metals enable complex reactor-geo…
View article: Electrochemical Methods in the Cloud: FreiStat, an IoT-Enabled Embedded Potentiostat
Electrochemical Methods in the Cloud: FreiStat, an IoT-Enabled Embedded Potentiostat Open
Embedded potentiostats enable electrochemical measurements in the Internet-of-Things (IoT) or other decentralized applications, such as remote environmental monitoring, electrochemical energy systems, and biomedical point-of-care applicati…
View article: Advanced electrochemical potential monitoring for improved understanding of electrical neurostimulation protocols
Advanced electrochemical potential monitoring for improved understanding of electrical neurostimulation protocols Open
Objective. Current-controlled neurostimulation is increasingly used in the clinical treatment of neurological disorders and widely applied in neural prostheses such as cochlear implants. Despite its importance, time-dependent potential tra…
View article: Standard cochlear implants as intracochlear oxygen sensors
Standard cochlear implants as intracochlear oxygen sensors Open
The cochlear implant (CI) is the most famous neuroprotheses worldwide. By direct electrical stimulation of the auditory nerve it compensates hearing loss in patients. The platinum (Pt) electrodes of the CI are comparable to those of bio- a…
View article: Electrochemical microelectrode degradation monitoring: in situ investigation of platinum corrosion at neutral pH
Electrochemical microelectrode degradation monitoring: in situ investigation of platinum corrosion at neutral pH Open
Objective . The stability of platinum and other noble metal electrodes is critical for neural implants, electrochemical sensors, and energy sources. Beyond the acidic or alkaline environment found in most electrochemical studies, the inves…
View article: Bioprinting-based automated deposition of single cancer cell spheroids into oxygen sensor microelectrode wells
Bioprinting-based automated deposition of single cancer cell spheroids into oxygen sensor microelectrode wells Open
With an advanced bioprinter, we print cancer cell spheroids directly into chip-based oxygen microsensors to determine single spheroid metabolism and drug responses.
View article: Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures Open
An organ-on-chip platform equipped with microsensors for long-term microfluidic cultivation and metabolic monitoring (O 2 , Glu, Lac) of 3D tumour organoid cultures grown from patient-derived single cancer stem cells.
View article: Electrochemical methods for neural interface electrodes
Electrochemical methods for neural interface electrodes Open
Objective . Neural interfaces often rely on charge transfer processes between electrodes and the tissue or electrolyte. Electrochemical processes are at the core of electrode function and, therefore, the key to neural interface stability, …
View article: Microsensor Electrodes for 3D Inline Process Monitoring in Multiphase Microreactors
Microsensor Electrodes for 3D Inline Process Monitoring in Multiphase Microreactors Open
We present an electrochemical microsensor for the monitoring of hydrogen peroxide direct synthesis in a membrane microreactor environment by measuring the hydrogen peroxide and oxygen concentrations. In prior work, for the first time, we p…
View article: New life for old wires: electrochemical sensor method for neural implants
New life for old wires: electrochemical sensor method for neural implants Open
Objective . Electrochemical microsensors based on noble metals can give essential information on their microenvironment with high spatio-temporal resolution. However, most advanced chemo- and biosensors lack the long-term stability for phy…
View article: FS: Bioelectronic Medicine
FS: Bioelectronic Medicine Open
Only thin-film electrodes can meet the demands of highly selective and high channel-count electrical neural stimulations.They are used in neural applications to ensure efficacious stimulations and recordings.In comparison to the often used…
View article: Deposition of Copper Nanofilms by Surface-Limited Redox Replacement of Underpotentially Deposited Lead on Polycrystalline Gold
Deposition of Copper Nanofilms by Surface-Limited Redox Replacement of Underpotentially Deposited Lead on Polycrystalline Gold Open
Electrochemical atomic layer deposition (E-ALD) of copper on polycrystalline gold is a promising method to achieve highly reproducible nanofilms. Cu films of more than 30 nm were deposited by the repetitive execution of underpotential depo…
View article: Active Potentiometry for Dissolved Oxygen Monitoring with Platinum Electrodes
Active Potentiometry for Dissolved Oxygen Monitoring with Platinum Electrodes Open
Potentiometric oxygen monitoring using platinum as the electrode material was enabled by the combination of conventional potentiometry with active prepolarization protocols, what we call active potentiometry. The obtained logarithmic trans…
View article: Sensor Access to the Cellular Microenvironment Using the Sensing Cell Culture Flask
Sensor Access to the Cellular Microenvironment Using the Sensing Cell Culture Flask Open
The Sensing Cell Culture Flask (SCCF) is a cell culture monitoring system accessing the cellular microenvironment in 2D cell culture using electrochemical microsensors. The system is based on microfabricated sensor chips embedded in standa…
View article: Microsensor systems for cell metabolism – from 2D culture to organ-on-chip
Microsensor systems for cell metabolism – from 2D culture to organ-on-chip Open
We discuss microsensors for cell culture monitoring from 2D culture to organ-on-chip systems, including sensor principles, fabrication and culture formats.
View article: Pericellular Oxygen Monitoring during Low-Level Light Therapy in Cell Culture Using a Microsensor System
Pericellular Oxygen Monitoring during Low-Level Light Therapy in Cell Culture Using a Microsensor System Open
An electrochemical microsensor system to monitor the pericellular oxygen concentration of fibroblasts during low-level light therapy in vitro was developed. The system provides in-sight into the metabolism of the cells during and in conseq…
View article: Highly Sensitive Electrochemical Glutamate Microsensors for Food Analysis
Highly Sensitive Electrochemical Glutamate Microsensors for Food Analysis Open
Electrochemical microsensors are ideal to measure substances with low concentration in complex environments. The primary excitatory neurotransmitter l-glutamate is present in many foods as a distinctive flavour (enhancer) with a wide conce…
View article: Electrochemical Multisensor System for Monitoring the Hydrogen Peroxide Direct Synthesis in Microreactors
Electrochemical Multisensor System for Monitoring the Hydrogen Peroxide Direct Synthesis in Microreactors Open
We present an electrochemical sensor system for the detection of hydrogen peroxide inside a direct synthesis microreactor. The setup allows the online, in situ measurement of high reactant concentrations by amperometric detection across th…
View article: Electrochemical microsensor system for cancer research on photodynamic therapy <i>in vitro</i>
Electrochemical microsensor system for cancer research on photodynamic therapy <i>in vitro</i> Open
An electrochemical microsensor system to investigate photodynamic therapy of cancer cells in vitro was developed and applied to monitor the cellular respiration during and after photodynamic therapy. The redox activity and therefore influe…
View article: Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform
Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform Open
The excessive use of antibiotics in human and veterinary medicine causes the emergence of multidrug resistant bacteria. In this context, the surveillance of many different antibiotics provokes a worldwide challenge. Hence, fast and versati…
View article: Microfabricated, amperometric, enzyme-based biosensors for in vivo applications
Microfabricated, amperometric, enzyme-based biosensors for in vivo applications Open
Miniaturized electrochemical in vivo biosensors allow the measurement of fast extracellular dynamics of neurotransmitter and energy metabolism directly in the tissue. Enzyme-based amperometric biosensing is characterized by high specificit…
View article: Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique
Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique Open
Here, we present a novel approach to increase the degree of miniaturization as well as the sensitivity of biosensor platforms by the optimization of microfluidic stop-flow techniques independent of the applied detection technique (e.g. ele…
View article: A novel study of the kinetics of external hierarchical nanostructures in methanol fuel cell
A novel study of the kinetics of external hierarchical nanostructures in methanol fuel cell Open
For the purpose of a direct methanol fuel cell (DMFC), this research investigates the kinetics of methanol oxidation in a porous layer consisting of external hierarchical nanostructures through 2D COMSOL simulation. Three different lengths…
View article: Stability of Non-enzymatic Glucose Sensor Based on Platinum Micro-/Nanostructures
Stability of Non-enzymatic Glucose Sensor Based on Platinum Micro-/Nanostructures Open
Stability of hierarchical micro- and nanostructured platinum electrodes for non-enzymatic glucose sensors were investigated taking into account the two major aspects of stability. The first aspect, the loss of sensitivity due to poisoning …