Jan Lamote
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View article: A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
A dynamic gene regulatory code drives synaptic development of hippocampal granule cells Open
Connecting neurons into functional circuits requires the formation, maturation, and plasticity of synapses. While advances have been made in identifying individual genes regulating synapse development, the molecular programs orchestrating …
View article: Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics Open
Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequentially through a temporal patterning mechan…
View article: A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
A dynamic gene regulatory code drives synaptic development of hippocampal granule cells Open
Connecting neurons into functional circuits requires the formation, maturation, and plasticity of synapses. While advances have been made in identifying individual genes regulating synapse development, the molecular programs orchestrating …
View article: Author response: Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss
Author response: Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss Open
View article: Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss
Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss Open
Parkinson’s disease (PD) is commonly associated with the loss of dopaminergic neurons in the substantia nigra, but many other cell types are affected even before neuron loss occurs. Recent studies have linked oligodendrocytes to early stag…
View article: Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss
Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss Open
Parkinson’s disease (PD) is commonly associated with the loss of dopaminergic neurons in the substantia nigra, but many other cell types are affected even before neuron loss occurs. Recent studies have linked oligodendrocytes to early stag…
View article: Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss
Parkinson’s disease-associated Pink1 loss disrupts vesicle trafficking in Ensheathing glia causing dopaminergic neuron synapse loss Open
Parkinson’s disease (PD) is commonly associated with the loss of dopaminergic neurons in the substantia nigra , but many other cell types are affected even before neuron loss occurs. Recent studies have linked oligodendrocytes to early sta…
View article: APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia Open
The major genetic risk factor for Alzheimer’s disease (AD), APOE4 , accelerates beta-amyloid (Aβ) plaque formation, but whether this is caused by APOE expressed in microglia or astrocytes is debated. We express here the human APOE isoforms…
View article: Tactical planning of a reconfigurable cellular assembly system: A case study
Tactical planning of a reconfigurable cellular assembly system: A case study Open
View article: Multi-level approach to virtual commissioning: a reconfigurable assembly system case
Multi-level approach to virtual commissioning: a reconfigurable assembly system case Open
Software plays a key role in modern automated systems. Testing the control software is one of the final steps in the development process and when done on the physical set up, it creates risks (e.g. project delay, system damage and operator…
View article: Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio
Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio Open
View article: Robot-assisted thoracoscopic diaphragm plication for symptomatic diaphragm paralysis after cryoballoon ablation
Robot-assisted thoracoscopic diaphragm plication for symptomatic diaphragm paralysis after cryoballoon ablation Open
Key Teaching Points•Phrenic nerve injury is the most common complication after cryoballoon ablation. Especially on the right side, the risk is high owing to the close relation between the phrenic nerve and the pulmonary veins.•Diaphragm pa…
View article: Phase I Study of <sup>68</sup>Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma
Phase I Study of <sup>68</sup>Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma Open
(68)Ga-HER2-Nanobody PET/CT is a safe procedure with a radiation dose comparable to other routinely used PET tracers. Its biodistribution is favorable, with the highest uptake in the kidneys, liver, and intestines but very low background l…