Jochen Leupold
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View article: On the choice of the phase difference increment in radiofrequency-spoiled gradient-echo magnetic resonance imaging of liquids with consideration of diffusion
On the choice of the phase difference increment in radiofrequency-spoiled gradient-echo magnetic resonance imaging of liquids with consideration of diffusion Open
In magnetic resonance imaging, the radiofrequency-spoiled gradient-echo method aims for fast acquisition of T1-weighted images. The spoiling mechanism is driven by the radiofrequency phase difference increment. In clinical (in-vivo) imagin…
View article: In Search for a Pathogenesis of Major Depression and Suicide—A Joint Investigation of Dopamine and Fiber Tract Anatomy Focusing on the Human Ventral Mesencephalic Tegmentum: Description of a Workflow
In Search for a Pathogenesis of Major Depression and Suicide—A Joint Investigation of Dopamine and Fiber Tract Anatomy Focusing on the Human Ventral Mesencephalic Tegmentum: Description of a Workflow Open
Major depressive disorder (MDD) is prevalent with a high subjective and socio-economic burden. Despite the effectiveness of classical treatment methods, 20–30% of patients stay treatment-resistant. Deep Brain Stimulation of the superolater…
View article: Morphology and Anatomy of Branch–Branch Junctions in Opuntia ficus-indica and Cylindropuntia bigelovii: A Comparative Study Supported by Mechanical Tissue Quantification
Morphology and Anatomy of Branch–Branch Junctions in Opuntia ficus-indica and Cylindropuntia bigelovii: A Comparative Study Supported by Mechanical Tissue Quantification Open
The Opuntioideae include iconic cacti whose lateral branch–branch junctions are intriguing objects from a mechanical viewpoint. We have compared Opuntia ficus-indica, which has stable branch connections, with Cylindropuntia bigelovii, whos…
View article: MR-compatible optical microscope for in-situ dual-mode MR-optical microscopy
MR-compatible optical microscope for in-situ dual-mode MR-optical microscopy Open
We present the development of a dual-mode imaging platform that combines optical microscopy with magnetic resonance microscopy. Our microscope is designed to operate inside a 9.4T small animal scanner with the option to use a 72mm bore ani…
View article: Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction
Analysis of accelerated 4D flow MRI in the murine aorta by radial acquisition and compressed sensing reconstruction Open
Preclinical 4D flow MRI remains challenging and is restricted for parallel imaging acceleration due to the limited number of available receive channels. A radial acquisition with combined parallel imaging and temporal compressed sensing re…
View article: Corrigendum: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy
Corrigendum: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy Open
In the published article, there were errors in affiliations 2 and 3. Instead of “Experimental Epilepsy Research, Department of Neurosurgery, Medical Center – University of Freiburg, Freiburg, Germany” and “Department Neurosurgery, Experime…
View article: Comparative Analyses of the Self-Sealing Mechanisms in Leaves of Delosperma cooperi and Delosperma ecklonis (Aizoaceae)
Comparative Analyses of the Self-Sealing Mechanisms in Leaves of Delosperma cooperi and Delosperma ecklonis (Aizoaceae) Open
Within the Aizoaceae, the genus Delosperma exhibits a vast diversification colonizing various ecological niches in South-Africa and showing evolutionary adaptations to dry habitats that might include rapid self-sealing. Leaves of Delosperm…
View article: Data availability file
Data availability file Open
Occurance and climate data, Morphometry data, Biomechanical data to Delosperma ecklonis and Delosperma cooperi
View article: Data availability file
Data availability file Open
Occurance and climate data, Morphometry data, Biomechanical data to Delosperma ecklonis and Delosperma cooperi
View article: Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy
Histological Correlates of Diffusion-Weighted Magnetic Resonance Microscopy in a Mouse Model of Mesial Temporal Lobe Epilepsy Open
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy. It is frequently associated with abnormal MRI findings, which are caused by underlying cellular, structural, and chemical changes at the micro-scale. In the cu…
View article: Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi‐echo balanced steady‐state free precession at 3 T
Dynamic 2D and 3D mapping of hyperpolarized pyruvate to lactate conversion in vivo with efficient multi‐echo balanced steady‐state free precession at 3 T Open
The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi‐echo balanced steady‐state free precessi…
View article: A seed flying like a bullet: ballistic seed dispersal in Chinese witch-hazel (<i>Hamamelis mollis</i>OLIV., Hamamelidaceae)
A seed flying like a bullet: ballistic seed dispersal in Chinese witch-hazel (<i>Hamamelis mollis</i>OLIV., Hamamelidaceae) Open
The fruits of Chinese witch-hazel ( Hamamelis mollis , Hamamelidaceae) act as ‘drying squeeze catapults', shooting their seeds several metres away. During desiccation, the exocarp shrinks and splits open, and subsequent endocarp deformatio…
View article: Resolving Form–Structure–Function Relationships in Plants with MRI for Biomimetic Transfer
Resolving Form–Structure–Function Relationships in Plants with MRI for Biomimetic Transfer Open
In many biomimetic approaches, a deep understanding of the form–structure–function relationships in living and functionally intact organisms, which act as biological role models, is essential. This knowledge is a prerequisite for the ident…
View article: Should patients with brain implants undergo MRI?
Should patients with brain implants undergo MRI? Open
Patients suffering from neuronal degenerative diseases are increasingly being equipped with neural implants to treat symptoms or restore functions and increase their quality of life. Magnetic resonance imaging (MRI) would be the modality o…
View article: Preclinical 4D-flow magnetic resonance phase contrast imaging of the murine aortic arch
Preclinical 4D-flow magnetic resonance phase contrast imaging of the murine aortic arch Open
The described setup allows analyzing pathophysiologies in mouse models of cardiovascular diseases in the aorta and its branches with better image quality and higher spatial and temporal resolution than previous Cartesian publications. Path…
View article: A comparison of Lenz lenses and LC resonators for NMR signal enhancement
A comparison of Lenz lenses and LC resonators for NMR signal enhancement Open
High signal‐to‐noise ratio (SNR) of the NMR signal has always been a key target that drives massive research effort in many fields. Among several parameters, a high filling factor of the MR coil has proven to boost the SNR. In case of smal…
View article: Magnetic resonance imaging reveals functional anatomy and biomechanics of a living dragon tree
Magnetic resonance imaging reveals functional anatomy and biomechanics of a living dragon tree Open
Magnetic resonance imaging (MRI) was used to gain in vivo insight into load-induced displacements of inner plant tissues making a non-invasive and non-destructive stress and strain analysis possible. The central aim of this study was the i…
View article: Nanoprobes for Multimodal Visualization of Bone Mineral Phase in Magnetic Resonance and Near-Infrared Optical Imaging
Nanoprobes for Multimodal Visualization of Bone Mineral Phase in Magnetic Resonance and Near-Infrared Optical Imaging Open
Imaging agents with affinity for bone can enable early detection of changes to bone mineral density, which is a hallmark of many bone-associated pathologies such as Paget's disease and osteoporosis. Here, we report the development of a pol…
View article: Pulseq: A rapid and hardware-independent pulse sequence prototyping framework
Pulseq: A rapid and hardware-independent pulse sequence prototyping framework Open
A high-level, flexible and hardware-independent approach to sequence programming is ideal for the rapid development of new sequences. The framework is currently not suitable for large patient studies or routine scanning although this would…