Jochen Roeper
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View article: A fast and tiny current as common generator of slow regular pacemaking in brain and heart
A fast and tiny current as common generator of slow regular pacemaking in brain and heart Open
Slow pacemaking is a key physiological process in specific excitable cells, yet its underlying mechanisms remain debated. Here we identify a conserved, voltage-dependent pacemaker current that is essential for slow, regular firing in both …
View article: Rebound Bursting Selectively Enables Fast Dynamics in Dopamine Midbrain Neurons Projecting to the Dorsolateral Striatum
Rebound Bursting Selectively Enables Fast Dynamics in Dopamine Midbrain Neurons Projecting to the Dorsolateral Striatum Open
Dopamine (DA) midbrain neurons are involved in a wide array of key brain functions including movement control and reward-based learning. They are also critical for major brain disorders such as Parkinson’s disease or schizophrenia. DA neur…
View article: Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity
Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity Open
Dopamine (DA) neurons in the substantia nigra (SN) control several essential functions, including the voluntary movement, learning and motivated behavior. Healthy DA SN neurons show diverse firing patterns in vivo , ranging from slow pacem…
View article: Chronic optogenetic stimulation of dentate gyrus granule cells in mouse organotypic slice cultures synaptically drives mossy cell degeneration
Chronic optogenetic stimulation of dentate gyrus granule cells in mouse organotypic slice cultures synaptically drives mossy cell degeneration Open
Objective Degeneration of hilar mossy cells in the dentate gyrus is an important hallmark of hippocampal sclerosis and is often observed in patients with temporal lobe epilepsy. To understand the pathogenesis of hippocampal sclerosis and d…
View article: Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures
Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures Open
Organotypic slice cultures (OTCs) are versatile tools for studying long-term structure-function relationships of neurons within a defined network (e.g. hippocampus). We developed a method for repeated experimenter-controlled activation of …
View article: Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons
Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons Open
Dissecting the diversity of midbrain dopamine (DA) neurons by optotagging is a promising addition to better identify their functional properties and contribution to motivated behavior. Retrograde molecular targeting of DA neurons with spec…
View article: The human channel gating–modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome–like phenotype in mice
The human channel gating–modifying A749G CACNA1D (Cav1.3) variant induces a neurodevelopmental syndrome–like phenotype in mice Open
Germline de novo missense variants of the CACNA1D gene, encoding the pore-forming α1 subunit of Cav1.3 L-type Ca2+ channels (LTCCs), have been found in patients with neurodevelopmental and endocrine dysfunction, but their disease-causing p…
View article: Ca <sub>v</sub> 1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons
Ca <sub>v</sub> 1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons Open
The low-threshold L-type calcium channel Ca v 1.3 accelerates the pacemaker rate in the heart, but its functional role for the extended dynamic range of neuronal firing is still unresolved. Here, we show that Ca v 1.3 calcium channels act …
View article: Patterns of Domain-Specific Learning Among Medical Undergraduate Students in Relation to Confidence in Their Physiology Knowledge: Insights From a Pre–post Study
Patterns of Domain-Specific Learning Among Medical Undergraduate Students in Relation to Confidence in Their Physiology Knowledge: Insights From a Pre–post Study Open
Research Focus The promotion of domain-specific knowledge is a central goal of higher education and, in the field of medicine, it is particularly essential to promote global health. Domain-specific knowledge on its own is not exhaustive; c…
View article: Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons Open
The firing activity of ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) dopaminergic (DA) neurons is an important factor in shaping DA release and its role in motivated behavior. Dendrites in DA neurons are the main po…
View article: Decision letter: Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework
Decision letter: Temporal derivative computation in the dorsal raphe network revealed by an experimentally driven augmented integrate-and-fire modeling framework Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract By means of…
View article: Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons
Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons Open
Two subpopulations of midbrain dopamine (DA) neurons are known to have different dynamic firing ranges in vitro that correspond to distinct projection targets: the originally identified conventional DA neurons project to the dorsal striatu…
View article: Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice
Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice Open
Significance Impaired cell cycle regulation of neural stem and progenitor cells can affect cortical development and cause microcephaly. During cell cycle progression, the cellular membrane potential changes through ion channel activity and…
View article: Recovery of the full<i>in vivo</i>firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity
Recovery of the full<i>in vivo</i>firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity Open
Dopamine (DA) neurons in the substantia nigra (SN) control several essential functions, including the voluntary movement, learning and motivated behavior. Healthy DA SN neurons show diverse firing patterns in vivo , ranging from slow pacem…
View article: Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice
Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice Open
The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells. The requirement for precise spatiotemporal control of proliferation and cell fate places a high demand on the cell division machi…
View article: α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms Open
Targeting α-synuclein to intact brainstem neurons drives gastrointestinal dysregulation seen in prodromal Parkinson’s disease.
View article: An unconventional conductance is required for pacemaking of nigral dopamine neurons
An unconventional conductance is required for pacemaking of nigral dopamine neurons Open
Although several ionic mechanisms are known to control rate and regularity of the pacemaker in dopamine (DA) neurons from the substantia nigra pars compacta (SNc), a conductance essential for pacing has yet to be defined. Here we provide p…
View article: Undergraduate Students’ Critical Online Reasoning—Process Mining Analysis
Undergraduate Students’ Critical Online Reasoning—Process Mining Analysis Open
To successfully learn using open Internet resources, students must be able to critically search, evaluate and select online information , and verify sources. Defined as critical online reasoning (COR), this construct is operationalized on …
View article: Narratives and Their Impact on Students’ Information Seeking and Critical Online Reasoning in Higher Education Economics and Medicine
Narratives and Their Impact on Students’ Information Seeking and Critical Online Reasoning in Higher Education Economics and Medicine Open
The digital and information age has fundamentally transformed the way in which students learn and the study material they have at their disposal, especially in higher education. Students need to possess a number of higher-order cognitive a…
View article: Replication Data for: In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons
Replication Data for: In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons Open
Replication Data for: In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons
View article: Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research
Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research Open
Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from the discoveries made in familial and/or sporadic forms of PD in the Caucasian population. The transferability and the clinical utility of geneti…
View article: Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo
Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo Open
Communication with the hematopoietic system is a vital component of regulating brain function in health and disease. Traditionally, the major routes considered for this neuroimmune communication are by individual molecules such as cytokine…
View article: Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates
Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates Open
Parkinson disease (PD), one of the most common neurodegenerative disorder, is believed to be driven by toxic α-synuclein aggregates eventually resulting in selective loss of vulnerable neuron populations, prominent among them, nigrostriata…
View article: In vivo functional diversity of midbrain dopamine neurons within identified axonal projections
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections Open
Functional diversity of midbrain dopamine (DA) neurons ranges across multiple scales, from differences in intrinsic properties and connectivity to selective task engagement in behaving animals. Distinct in vitro biophysical features of DA …