Jochen Weigt
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View article: Prevalence and Impact on Quality of Life of Small Intestinal Bacterial Overgrowth (SIBO)-Related Symptoms in Patients with Upper Gastrointestinal Cancer
Prevalence and Impact on Quality of Life of Small Intestinal Bacterial Overgrowth (SIBO)-Related Symptoms in Patients with Upper Gastrointestinal Cancer Open
Introduction: Although patients with upper gastrointestinal (GI) cancer have an increased risk of developing small intestinal bacterial overgrowth (SIBO) due to disease- and treatment-related factors, SIBO remains underdiagnosed in oncolog…
View article: Exploring microRNAs in Bile Duct Stents as Diagnostic Biomarkers for Biliary Pathologies
Exploring microRNAs in Bile Duct Stents as Diagnostic Biomarkers for Biliary Pathologies Open
Background/Objectives: Obstruction of the biliary duct may be caused by various conditions ranging from chronic inflammation to neoplasia, including cholangiocarcinoma (CCA). While the definite histological diagnosis of intrahepatic lesion…
View article: Freehand suturing to apply traction during endoscopic submucosal dissection
Freehand suturing to apply traction during endoscopic submucosal dissection Open
The technique of freehand suturing in gastrointestinal endoscopy has evolved through technical developments such as knotless barbed wire sutures and needle manipulators, with initial publications showing promising results [1] [2]. The main…
View article: Influence of the Bile Acid Transporter Genes ABCB4, ABCB8, and ABCB11 and the Farnesoid X Receptor on the Response to Ursodeoxycholic Acid in Patients with Nonalcoholic Steatohepatitis
Influence of the Bile Acid Transporter Genes ABCB4, ABCB8, and ABCB11 and the Farnesoid X Receptor on the Response to Ursodeoxycholic Acid in Patients with Nonalcoholic Steatohepatitis Open
The prevalence of NAFLD and NASH is increasing worldwide, and there is no approved medical treatment until now. Evidence has emerged that interfering with bile acid metabolism may lead to improvement in NASH. In this study, 28 patients wit…
View article: BISCIT: Biliary Interventions in critically ill patients with Secondary Sclerosing Cholangitis – a study protocol for a multicenter, randomized, controlled parallel group trial
BISCIT: Biliary Interventions in critically ill patients with Secondary Sclerosing Cholangitis – a study protocol for a multicenter, randomized, controlled parallel group trial Open
Background: Progress of cholangitis to cholangiosepsis is a frequent observation in patients with secondary sclerosing cholangitis in critically ill patients (SSC-CIP). Adequate biliary drainage may reduce episodes of cholangiosepsis and t…
View article: Influence of Artificial Intelligence on the Adenoma Detection Rate throughout the Day
Influence of Artificial Intelligence on the Adenoma Detection Rate throughout the Day Open
Background: Artificial intelligence systems recently demonstrated an increase in polyp and adenoma detection rate. Over the daytime, the adenoma detection rate decreases as tiredness leads to a lack of attention. It is not clear if a polyp…
View article: Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial)
Percutaneous transhepatic or endoscopic ultrasound-guided biliary drainage in malignant distal bile duct obstruction using a self-expanding metal stent: Study protocol for a prospective European multicenter trial (PUMa trial) Open
Background Endoscopic ultrasound-guided biliary drainage (EUS-BD) was associated with better clinical success and a lower rate of adverse events (AEs) than fluoroscopy-guided percutaneous transhepatic biliary drainage (PTBD) in recent sing…
View article: LiMAx Prior to Radioembolization for Hepatocellular Carcinoma as an Additional Tool for Patient Selection in Patients with Liver Cirrhosis
LiMAx Prior to Radioembolization for Hepatocellular Carcinoma as an Additional Tool for Patient Selection in Patients with Liver Cirrhosis Open
Background and Aims: Radioembolization (RE) has recently demonstrated a non-inferior survival outcome compared to systemic therapy for advanced hepatocellular carcinoma (HCC). Therefore, current guidelines recommend RE for patients with ad…
View article: Endoscopic Imaging Technology Today
Endoscopic Imaging Technology Today Open
One of the most applied imaging methods in medicine is endoscopy. A highly specialized image modality has been developed since the first modern endoscope, the “Lichtleiter” of Bozzini was introduced in the early 19th century. Multiple medi…
View article: CoronaCare study protocol: an ethnographic study of the risks to and potential for social health during the COVID-19 pandemic
CoronaCare study protocol: an ethnographic study of the risks to and potential for social health during the COVID-19 pandemic Open
Introduction German government regulations such as physical distancing and limited group numbers, designed to curb the spread of COVID-19, have had far-reaching consequences for the very foundations of social life. They have, to name only …
View article: Cold versus hot polypectomy/endoscopic mucosal resection–A review of current evidence
Cold versus hot polypectomy/endoscopic mucosal resection–A review of current evidence Open
Background Colonoscopy with polypectomy substantially reduces the risk of colorectal cancer (CRC) but interval cancers still account for 9% of all CRCs, some of which are due to incomplete resection. Aim The aim of this review is to compar…
View article: Can a Polyp Detection and Characterization System Predict Complete Resection?
Can a Polyp Detection and Characterization System Predict Complete Resection? Open
Introduction: Artificial Intelligence (AI) is one of the most evolving fields in endoscopy. We aimed to test if a system for polyp detection and polyp characterization can be used to predict complete endoscopic resection of colon adenomas.…
View article: Inflammatory microRNAs in gastric mucosa are modulated by Helicobacter pylori infection and proton-pump inhibitors but not by aspirin or NSAIDs
Inflammatory microRNAs in gastric mucosa are modulated by Helicobacter pylori infection and proton-pump inhibitors but not by aspirin or NSAIDs Open
Gastric carcinogenesis is associated with alterations of microRNAs (miRNAs) and reversal of these alterations may be a crucial element in cancer prevention. Here we evaluate the influence of H . pylori eradication, low-dose aspirin (LDA), …
View article: Biopsy Sampling in Upper Gastrointestinal Endoscopy: A Survey from 10 Tertiary Referral Centres Across Europe
Biopsy Sampling in Upper Gastrointestinal Endoscopy: A Survey from 10 Tertiary Referral Centres Across Europe Open
Background: Guidelines give robust recommendations on which biopsies should be taken when there is endoscopic suggestion of gastric inflammation. Adherence to these guidelines often seems arbitrary. This study aimed to give an overview on …
View article: Supplementary Material for: Biopsy Sampling in Upper Gastrointestinal Endoscopy: A Survey from 10 Tertiary Referral Centres Across Europe
Supplementary Material for: Biopsy Sampling in Upper Gastrointestinal Endoscopy: A Survey from 10 Tertiary Referral Centres Across Europe Open
Background: Guidelines give robust recommendations on which biopsies should be taken when there is endoscopic suggestion of gastric inflammation. Adherence to these guidelines often seems arbitrary. This study aimed to give an overview on …
View article: Wire-over-wire technique enables placement of a second parallel guidewire into a pseudocyst for drainage
Wire-over-wire technique enables placement of a second parallel guidewire into a pseudocyst for drainage Open
Recently we reported a new technique that enables the positioning of a second guidewire following a first wire without the use of a catheter [1]. Using a wire with a double-bend tip, which forms the shape of a helix, it is possible to wrap…
View article: Wire-over-wire technique
Wire-over-wire technique Open
Usually guidewires are used to lead catheters or other medical devices through the human body. For the first time, we present a technique of advancing a guidewire over another guidewire without the use of a catheter.
View article: Combined Gastric and Colorectal Cancer Screening—A New Strategy
Combined Gastric and Colorectal Cancer Screening—A New Strategy Open
Background: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates. Methods: Serum samples were prospectively collecte…
View article: Addressing the Horizontal Gender Division of Labor: A Case Study of Support and Obstacles in a Heavy Industry Plant in Iceland
Addressing the Horizontal Gender Division of Labor: A Case Study of Support and Obstacles in a Heavy Industry Plant in Iceland Open
In the present article, we analyze a project in a heavy industry plant in Iceland in which the management aims to hire an equal number of women and men and, thereby, to work against the gender segregation of work. For their efforts, called…
View article: Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis
Expression of microRNAs in the ascites of patients with peritoneal carcinomatosis and peritonitis Open
BACKGROUND Peritoneal carcinomatosis (PCA) has a prognostic role in patients with gastrointestinal cancers. The differential diagnosis may be challenging due to the low sensitivity of cytology. Although microRNAs (miRNAs) have been a focus…
View article: Road Map fluoroscopy successfully guides endoscopic interventions in the esophagus
Road Map fluoroscopy successfully guides endoscopic interventions in the esophagus Open
Background and study aims Road Map (RM) fluoroscopy is a radiological technique that enables visualization of anatomic structures using image subtraction at peak opacification. RM fluoroscopy has never previously been evaluated for use in …
View article: The freedom of choice
The freedom of choice Open
Endoscopic stent placement is the current standard treatment for benign biliary strictures (BBS).
View article: <i>Helicobacter pylori</i>vacA genotype is a predominant determinant of immune response to<i>Helicobacter pylori</i>CagA
<i>Helicobacter pylori</i>vacA genotype is a predominant determinant of immune response to<i>Helicobacter pylori</i>CagA Open
Serological immune response to H. pylori cagA+ strain in H. pylori infected patients is strongly associated with vacA polymorphism, suggesting the crucial role of bacterial factors in immune and clinical phenotype of the infection.
View article: Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study
Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study Open
The expression of leukotriene receptors was deregulated in esophageal squamous cell cancer. Up-regulation of LTB4R and down-regulation of CYSLTR2 gene expression may occur already in normal squamous esophageal epithelium of patients with e…
View article: Additional file 2: of Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study
Additional file 2: of Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study Open
Raw data of immunohistochemical scores and polymerase chain reactions. (XLS 10 kb)
View article: Anatomy-shaped design of a fully-covered, biliary, self-expandable metal stent for treatment of benign distal biliary strictures
Anatomy-shaped design of a fully-covered, biliary, self-expandable metal stent for treatment of benign distal biliary strictures Open
The new stent design has a low rate of migration. Biomechanical properties may explain this effect.
View article: A novel approach to esophageal stent removal in the setting of proximal stenosis and failure of the primary retrieval mechanism
A novel approach to esophageal stent removal in the setting of proximal stenosis and failure of the primary retrieval mechanism Open
A 75-year-old woman was admitted for the extraction of an esophageal fully covered metal stent (upper esophageal sphincter stent [80 × 20 mm]; Leufen Medical, Berlin, Germany). The stent had been implanted 5 weeks earlier to treat an esoph…