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View article: Personalized versus fixed tactile cueing in Parkinson’s disease: Protocol for a randomized controlled trial on gait automaticity
Personalized versus fixed tactile cueing in Parkinson’s disease: Protocol for a randomized controlled trial on gait automaticity Open
Background Gait automaticity, the ability of the brain to control locomotion with minimal use of executive-attentional resources, is altered in people with Parkinson’s disease (PD). Recently, we showed that step-synchronized tactile cueing…
View article: Comparison of the sustainability of the impact of team-based versus individual clinician-focused training of primary care professionals in serious illness conversations on caregiver burden of care: a secondary analysis of a cluster randomized trial
Comparison of the sustainability of the impact of team-based versus individual clinician-focused training of primary care professionals in serious illness conversations on caregiver burden of care: a secondary analysis of a cluster randomized trial Open
View article: Differences in pre-surgical baseline tear proteome are associated with persistent post-refractive surgery pain
Differences in pre-surgical baseline tear proteome are associated with persistent post-refractive surgery pain Open
View article: Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study
Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study Open
View article: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study
Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study Open
View article: Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study
Correction to: Comparison of fracture risk assessment tools in older men without prior hip or spine fracture: the MrOS study Open
View article: BLOOD MULTIOMIC PROFILES REFLECT SYSTEM STATES OF ORGANS IN MICE
BLOOD MULTIOMIC PROFILES REFLECT SYSTEM STATES OF ORGANS IN MICE Open
The rate of aging can vary among organs, as evidenced by organ-specific biological age models. Such models are typically constructed based on the blood biomarkers or phenotypes that are known to be specific to a particular organ. However, …
View article: LONGEVITY POLYGENIC RISK IN MULTIDOMAIN AGING AND LONG-TERM SURVIVAL AMONG OLDER WHITE AND BLACK ADULTS
LONGEVITY POLYGENIC RISK IN MULTIDOMAIN AGING AND LONG-TERM SURVIVAL AMONG OLDER WHITE AND BLACK ADULTS Open
This study aims to identify genetic characteristics of multi-dimensional aging and longevity by examining the association of longevity polygenic risk scores with multi-domain aging trajectories and long-term survival in older Non-Hispanic …
View article: Prospective cohort study investigating frequency and risk factors for acute pain 1 day after refractive surgery
Prospective cohort study investigating frequency and risk factors for acute pain 1 day after refractive surgery Open
Background/aims To examine demographic and clinical factors associated with ocular pain 1 day after refractive surgery. Methods Prospective study of individuals undergoing refractive surgery. Participants rated their ocular pain on a 0–10 …
View article: The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank Open
View article: Race, ethnicity, and considerations for data collection and analysis in research studies
Race, ethnicity, and considerations for data collection and analysis in research studies Open
Research studies involving human subjects require collection of and reporting on demographic data related to race and ethnicity. However, existing practices lack standardized guidelines, leading to misrepresentation and biased inferences a…
View article: PROSPECTIVE MULTI-OMIC ANALYSIS OF HUMAN LONGEVITY COHORTS IDENTIFIES ANALYTE NETWORKS ASSOCIATED WITH LONGEVITY
PROSPECTIVE MULTI-OMIC ANALYSIS OF HUMAN LONGEVITY COHORTS IDENTIFIES ANALYTE NETWORKS ASSOCIATED WITH LONGEVITY Open
Serum based biomarkers of longevity have long been sought to explain the mechanisms of healthy aging and longevity. Using a 1:3 case cohort design, the Longevity Consortium has produced untargeted mass spectrometry based proteomic and meta…
View article: Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers
Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers Open
View article: Mobility Rehab visual feedback system for gait rehabilitation in older adults
Mobility Rehab visual feedback system for gait rehabilitation in older adults Open
Background Gait and balance impairments are among the main causes of falls in older adults. The feasibility and effectiveness of adding sensor-based feedback to physical therapy (PT) in an outpatient PT setting is unknown. We evaluated the…
View article: Proteomic changes induced by longevity-promoting interventions in mice
Proteomic changes induced by longevity-promoting interventions in mice Open
View article: Melanoma literacy among the general population of three western <scp>US</scp> states
Melanoma literacy among the general population of three western <span>US</span> states Open
Melanoma is a significant cause of cancer death, despite being detectable without specialized or invasive technologies. Understanding barriers to preventive behaviors such as skin self‐examination (SSE) could help to define interventions f…
View article: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers
Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers Open
View article: 44 Seminar series on Anti-Racism in Data and Analysis
44 Seminar series on Anti-Racism in Data and Analysis Open
OBJECTIVES/GOALS: The mission of our new Anti-racism in Data and Analysis seminar series is to provide a forum for researchers to discuss the ways that race and racism show up in data and analysis so that we as scientists may work together…
View article: Latent phase duration and associated outcomes: a contemporary, population-based observational study
Latent phase duration and associated outcomes: a contemporary, population-based observational study Open
View article: Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease
Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease Open
View article: Experimental design considerations for studies of human tear proteins
Experimental design considerations for studies of human tear proteins Open
View article: Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease
Gait and balance in apolipoprotein Ɛ4 allele carriers in older adults and Parkinson’s disease Open
View article: The Instrumented Stand and Walk (ISAW) test to predict falls in older men
The Instrumented Stand and Walk (ISAW) test to predict falls in older men Open
View article: Systems-level patterns in biological processes are changed under prolongevity interventions and across biological age
Systems-level patterns in biological processes are changed under prolongevity interventions and across biological age Open
Aging manifests as progressive deterioration in cellular and systemic homeostasis, requiring systems-level perspectives to understand the gradual molecular dysregulation of underlying biological processes. Here, we report systems-level cha…
View article: Cognition as a mediator for gait and balance impairments in GBA-related Parkinson’s disease
Cognition as a mediator for gait and balance impairments in GBA-related Parkinson’s disease Open
The extent to which the heterogeneity of gait and balance problems in PD may be explained by genetic variation is unknown. Variants in the glucocerebrosidase ( GBA ) gene are the strongest known genetic risk factor for PD and are associate…
View article: Lower Leg Power and Grip Strength Are Associated With Increased Fall Injury Risk in Older Men: The Osteoporotic Fractures in Men Study
Lower Leg Power and Grip Strength Are Associated With Increased Fall Injury Risk in Older Men: The Osteoporotic Fractures in Men Study Open
Background Past research has not investigated both lower-extremity power and upper-extremity strength in the same fall injury study, particularly nonfracture fall injuries. Methods In the Osteoporotic Fractures in Men Study (baseline: N = …
View article: Peer-based Retention Of people who Use Drugs in Rural Research (PROUD-R<sup>2</sup>): a multisite, randomised, 12-month trial to compare efficacy of standard versus peer-based approaches to retain rural people who use drugs in research
Peer-based Retention Of people who Use Drugs in Rural Research (PROUD-R<sup>2</sup>): a multisite, randomised, 12-month trial to compare efficacy of standard versus peer-based approaches to retain rural people who use drugs in research Open
Introduction Rural communities bear a disproportionate share of the opioid and methamphetamine use disorder epidemics. Yet, rural people who use drugs (PWUD) are rarely included in trials testing new drug use prevention and treatment strat…
View article: The duration of spontaneous active and pushing phases of labour among 75,243 US women when intervention is minimal: A prospective, observational cohort study
The duration of spontaneous active and pushing phases of labour among 75,243 US women when intervention is minimal: A prospective, observational cohort study Open
View article: Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury
Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury Open
A history of traumatic brain injury (TBI) increases the odds of developing Alzheimer’s disease (AD). The long latent period between injury and dementia makes it difficult to study molecular changes initiated by TBI that may increase the ri…
View article: Effectiveness of the Mobility Rehab System for Mobility Training in Older Adults: A Pragmatic Clinical Trial
Effectiveness of the Mobility Rehab System for Mobility Training in Older Adults: A Pragmatic Clinical Trial Open
Introduction: Mobility impairments are among the main causes of falls in older adults and patients with neurological diseases, leading to functional dependence and substantial health care costs. Feedback-based interventions applied in cont…