Explanipedia

Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption Open

Matthew Pace, Ane Ogbe, Jacob Hurst, Nicola Robinson, Jodi Meyerowitz , et al. · 2022

Natural Killer (NK) cells play a key role in controlling HIV replication, with potential downstream impact on the size of the HIV reservoir and likelihood of viral rebound after antiretroviral therapy (ART) cessation. It is therefore impor…

Author response: Human MAIT cells respond to and suppress HIV-1 Open

Chansavath Phetsouphanh, Prabhjeet Phalora, Carl-Philipp Hackstein, John Thornhill, C. Mee Ling Munier , et al. · 2020

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers Open

Chansavath Phetsouphanh, Daniel L. Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz , et al. · 2019

Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell r…

Maintenance of Functional CD57+Cytolytic CD4+T Cells in HIV plus Elite Controllers Open

Chansavath Phetsouphanh, Daniel L. Aldridge, Emanuele Marchi, Munier Cml., Jodi Meyerowitz , et al. · 2019

Persistent elevation of Tim-3 and PD-1 on memory T cells despite early ART initiation during primary HIV infection Open

G.E. Martin, Matthew Pace, Jodi Meyerowitz, John Thornhill, Julianne Lwanga , et al. · 2019

CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype Open

John Thornhill, Matthew Pace, Geneviève Martin, Jonathan Hoare, S. Peake , et al. · 2019

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion Open

Geneviève Martin, Matthew Pace, Freya M. Shearer, Eva Zilber, Jacob Hurst , et al. · 2019

Initiation of antiretroviral therapy (ART) in early compared with chronic HIV infection is associated with a smaller HIV reservoir. This longitudinal analysis of 63 individuals who commenced ART during primary HIV infection (PHI) investiga…

Virological remission after antiretroviral therapy interruption in female African HIV seroconverters Open

Morgane Gossez, Geneviève Martin, Matthew Pace, Gita Ramjee, Anamika Premraj , et al. · 2018

We find evidence of greater probability of virological remission following treatment interruption among African participants, although we are unable to differentiate between sex, ethnicity and viral subtype. The finding warrants further in…

Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis–Specific T-Cell Responses Open

Lyle Murray, Iman Satti, Jodi Meyerowitz, Matthew D. Jones, Christian B. Willberg , et al. · 2018

HIV-associated impairment of CD4+ and CD8+Mtb-specific T-cell responses is antigen specific, particularly impacting responses to PPD and Rv2031c. Preferential depletion of Th17 cytokine-expressing CD4+ T cells suggests this T-cell subset m…

Follicular CD8+T-cells in gut-associated lymphoid tissue are associated with lower HIV-1 reservoir in the terminal ileum after ART initiated during primary HIV infection Open

John Thornhill, Geneviève Martin, Jacqueline Hoare, S. Peake, Matthew Pace , et al. · 2018

A pilot evaluation of whole blood finger-prick sampling for point-of-care HIV viral load measurement: the UNICORN study Open

Sarah Fidler, Heather Lewis, Jodi Meyerowitz, Kristin Kuldanek, John Thornhill , et al. · 2017

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue Open

Geneviève Martin, Matthew Pace, John Thornhill, Chansavath Phetsouphanh, Jodi Meyerowitz , et al. · 2017

The Fc receptor CD32 has been proposed as a marker for CD4 T cells latently infected with HIV. We demonstrate that enrichment for HIV DNA in CD32+ CD4 T cells can be found early in infection in both tissue and blood. However, we find no ev…

The impact of immunoglobulin in acute <span>HIV</span> infection on the <span>HIV</span> reservoir: a randomized controlled trial Open

Juan Tiraboschi, S Ray, K.D. Patel, Alastair Teague, Matthew Pace , et al. · 2017

Objectives Antiretroviral therapy ( ART ) during acute HIV infection ( AHI ) restricts the HIV reservoir, but additional interventions are necessary to induce a cure. Intravenous immunoglobulin ( IVIG ) is not HIV ‐specific but is safe and…

OA1-2 Enrichment of the HIV reservoir in CD32 + CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression Open

G.E. Martin, Matthew Pace, John Thornhill, Chansavath Phetsouphanh, Elizabeth Davies , et al. · 2017

Post-treatment control or treated controllers? Viral remission in treated and untreated primary HIV infection Open

Geneviève Martin, Morgane Gossez, James P. Williams, Wolfgang Stöhr, Jodi Meyerowitz , et al. · 2017

Consideration of spontaneous remission in untreated individuals will be critical to avoid overestimating the effect size of new interventions used in HIV cure studies.

Enrichment of the HIV reservoir in CD32+CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression Open

Geneviève Martin, Matthew Pace, John Thornhill, Chansavath Phetsouphanh, Elizabeth Davies , et al. · 2017

Short Communication: Lack of Effect of Maraviroc Intensification on Blood and Gut Reservoir Open

Juan Tiraboschi, Shuvra Ray, Kemal Patel, Matthew Pace, Prabhjeet Phalora , et al. · 2016

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microb…

4 Post-treatment control or treated controllers? The impact of ART on time to viral rebound in recent seroconverters Open

G.E. Martin, Morgane Gossez, Jon Williams, Wolfgang Stöhr, Jodi Meyerowitz , et al. · 2016

Exhaustion of activated CD8 T cells predicts disease progression in primary HIV-1 infection Open

Geneviève Martin, Nikos Pantazis, Matthias Hoffmann, Stephen Hickling, Jacob Hurst , et al. · 2016

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption Open

Jacob Hurst, Matthias Hoffmann, Matthew Pace, James P. Williams, John Thornhill , et al. · 2015

TR-08 * TARGETED COMBINATORIAL APPROACH FOR TREATMENT OF PEDIATRIC LOW GRADE GLIOMAS IN THE CONTEXT OF BRAFV600E AND KIAA1549:BRAF MUTATIONS Open

A. K. Olow, Sabine Mueller, Xiao-Dong Yang, Rintaro Hashizume, Jodi Meyerowitz , et al. · 2015

Pediatric low-grade gliomas (PLGG) constitute the most common group of central nervous system tumors in children.Viewed as a chronic disease, ideal therapy for PLGG should carry limited side effects that can be best achieved through select…

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