Joe P. Foley
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View article: Separation of weak acids, neutral compounds, and permanent anions using sequential elution liquid chromatography with tandem columns
Separation of weak acids, neutral compounds, and permanent anions using sequential elution liquid chromatography with tandem columns Open
This paper discusses the development of an analytical method by an alternative separation approach, sequential elution liquid chromatography (SE-LC), to separate permanently charged ions (anions), weak acids, and neutral compounds using an…
View article: A simulation-guided approach to the selection of RPLC columns for platform small molecule separations
A simulation-guided approach to the selection of RPLC columns for platform small molecule separations Open
Simulations were conducted to evaluate the potential of several hundred reversed-phase columns to separate small molecules. By calculating the retention factor of compounds in randomly generated virtual mixtures via the HSM (hydrophobic su…
View article: The Advantages and Applications of Tandem-Column Liquid Chromatography in Pharmaceutical Compound Separations
The Advantages and Applications of Tandem-Column Liquid Chromatography in Pharmaceutical Compound Separations Open
This research established a simulation based on the hydrophobic subtraction model (HSM) of retention and selectivity and basic liquid chromatography (LC) principles for tandem-column LC. The simulation was used to compare the separation po…
View article: Chiral and Achiral HPLC Separation of Chiral Pharmaceutical Compounds
Chiral and Achiral HPLC Separation of Chiral Pharmaceutical Compounds Open
This project is focused on developing a liquid chromatographic method that separates four Non-Steroidal Anti-Inflammatory Drugs (Ketoprofen, Naproxen, Ibuprofen, and Flurbiprofen) and three of the four pairs of enantiomers in one run. NSAI…
View article: Improved separation performance by using tandem-column LC with conventional U/HPLC instrumentation
Improved separation performance by using tandem-column LC with conventional U/HPLC instrumentation Open
View article: Improved separation performance by using tandem-column LC with conventional U/HPLC instrumentation
Improved separation performance by using tandem-column LC with conventional U/HPLC instrumentation Open
View article: Aqueous size-exclusion chromatography of polyelectrolytes on reversed-phase and hydrophilic interaction chromatography columns
Aqueous size-exclusion chromatography of polyelectrolytes on reversed-phase and hydrophilic interaction chromatography columns Open
View article: Chromatographic Separation and Stability Analysis of Small Interfering RNA and Lipid Vehicles Using Ion-Pair Reversed Phase Liquid Chromatography
Chromatographic Separation and Stability Analysis of Small Interfering RNA and Lipid Vehicles Using Ion-Pair Reversed Phase Liquid Chromatography Open
Chromatographic methods were developed capable of separating and quantitating siRNA, lipids, and their potential breakdown products due to oxidation or hydrolysis. Such methods are essential to developing lipid nanoparticles (LNPs) as a fo…
View article: Organic solvent modifier and temperature effects in non-aqueous size-exclusion chromatography on reversed-phase columns
Organic solvent modifier and temperature effects in non-aqueous size-exclusion chromatography on reversed-phase columns Open
View article: Effect of Flow Rate on High Performance Liquid Chromatography Column Re-equilibration after Gradient Elution
Effect of Flow Rate on High Performance Liquid Chromatography Column Re-equilibration after Gradient Elution Open
In traditional high-performance liquid chromatography (HPLC), column re-equilibration between gradient elution runs is necessary to prepare a column for subsequent experiments. This process replaces the final mobile phase in the column wit…
View article: Development of Experimental and Computational Techniques to Improve or Predict the Likelihood of Separation Success of Chromatographic and Electrophoretic Techniques
Development of Experimental and Computational Techniques to Improve or Predict the Likelihood of Separation Success of Chromatographic and Electrophoretic Techniques Open
In the method development process, it is imperative not only to be able to achieve a successful separation of all components of interest (all components fully resolved in a single experiment), but also to be able to achieve those separatio…
View article: Novel Chromatographic Approaches for Class Separations of Small Molecules
Novel Chromatographic Approaches for Class Separations of Small Molecules Open
Chromatographic separations have been a part of the analytical scientists' toolkit for over a century and the techniques are constantly being improved upon. As chromatography progresses, more difficult separations become possible, and even…
View article: Biotechnology and Bioengineering: Volume 112, Number 8, August 2015
Biotechnology and Bioengineering: Volume 112, Number 8, August 2015 Open