Joe T. Sharick
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View article: Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma
Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma Open
Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes of soft tissue sarcoma (STS). Complete surgical resection remains the mainstay treatment, while the high rate of locoregional recurrence constitutes the pred…
View article: Supplementary Data SD1 from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment
Supplementary Data SD1 from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment Open
Figure S1, S2, S3, Table S1 and S2
View article: Data from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment
Data from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment Open
Extracellular matrix (ECM) alignment contributes to metastasis in a number of cancers and is a known prognostic stromal factor; however, the mechanisms controlling matrix organization remain unclear. Cancer-associated fibroblasts (CAF) pla…
View article: Supplementary Data SD1 from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment
Supplementary Data SD1 from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment Open
Figure S1, S2, S3, Table S1 and S2
View article: Data from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment
Data from A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment Open
Extracellular matrix (ECM) alignment contributes to metastasis in a number of cancers and is a known prognostic stromal factor; however, the mechanisms controlling matrix organization remain unclear. Cancer-associated fibroblasts (CAF) pla…
View article: Table S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Stock culture and feeding media.
View article: Figure S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Dot plots corresponding to population distribution curves and graphs of individual replicates for bar graphs in Figure 4.
View article: Figure S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Individual replicates for data shown in Figure 5B.
View article: Table S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Stock culture and feeding media.
View article: Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Purpose:Cancer treatment is limited by inaccurate predictors of patient-specific therapeutic response. Therefore, some patients are exposed to unnecessary side effects and delays in starting effective therapy. A clinical tool that predicts…
View article: Table S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Detailed characteristics of CRC PDOCS.
View article: Supplementary Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Supplementary Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Supplementary Methods
View article: Figure S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S2 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Individual replicates for data shown in Figure 5B.
View article: Figure S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Individual replicates for data shown in Figure 5E.
View article: Table S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Detailed characteristics of CRC PDOCS.
View article: Supplementary Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Supplementary Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Supplementary Methods
View article: Figure S4 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S4 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
(A) Individual replicates of data shown in Figure 6A. (B) Individual replicates of data from Figure 6D.
View article: Figure S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S3 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Individual replicates for data shown in Figure 5E.
View article: Figure S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Dot plots corresponding to population distribution curves and graphs of individual replicates for bar graphs in Figure 4.
View article: Table S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Success rates for growing human cancers in spheroid culture
View article: Table S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Table S1 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Success rates for growing human cancers in spheroid culture
View article: Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Data from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
Purpose:Cancer treatment is limited by inaccurate predictors of patient-specific therapeutic response. Therefore, some patients are exposed to unnecessary side effects and delays in starting effective therapy. A clinical tool that predicts…
View article: Figure S4 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation
Figure S4 from Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Open
(A) Individual replicates of data shown in Figure 6A. (B) Individual replicates of data from Figure 6D.
View article: A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment
A Miniaturized Screening Platform to Identify Novel Regulators of Extracellular Matrix Alignment Open
Extracellular matrix (ECM) alignment contributes to metastasis in a number of cancers and is a known prognostic stromal factor; however, the mechanisms controlling matrix organization remain unclear. Cancer-associated fibroblasts (CAF) pla…
View article: Click chemistry functionalization of <scp>self‐assembling</scp> peptide hydrogels
Click chemistry functionalization of <span>self‐assembling</span> peptide hydrogels Open
Self‐assembling peptide (SAP) hydrogels provide a fibrous microenvironment to cells while also giving users control of biochemical and mechanical cues. Previously, biochemical cues were introduced by physically mixing them with SAPs prior …
View article: Pten regulates collagen fibrillogenesis by fibroblasts through SPARC
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC Open
Collagen deposition contributes to both high mammographic density and breast cancer progression. Low stromal PTEN expression has been observed in as many as half of breast tumors and is associated with increases in collagen deposition, how…
View article: MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC
MEK activation modulates glycolysis and supports suppressive myeloid cells in TNBC Open
Triple-negative breast cancers (TNBCs) are heterogeneous and aggressive, with high mortality rates. TNBCs frequently respond to chemotherapy, yet many patients develop chemoresistance. The molecular basis and roles for tumor cell-stromal c…
View article: Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment
Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment Open
New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments and discover novel therapies. Currently, methods to evaluate drug response in org…
View article: Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications
Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications Open
FLIM is advantageous for probing molecular environments of fluorophores to inform on fluorophore behavior that cannot be elucidated with intensity measurements alone. Development of FLIM technologies, analysis, and applications will furthe…
View article: Sample preparation strategies for high‐throughput mass spectrometry imaging of primary tumor organoids
Sample preparation strategies for high‐throughput mass spectrometry imaging of primary tumor organoids Open
Patient‐derived 3D organoids show great promise for understanding patient heterogeneity and chemotherapy response in human‐derived tissue. The combination of organoid culture techniques with mass spectrometry imaging provides a label‐free …