Joe Dennis
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View article: Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer
Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer Open
Etiologic heterogeneity in breast carcinogenesis needs to be well characterized for targeted prevention. Associations between menopausal hormonal therapy (MHT) and oral contraceptive (OC) use and breast cancer intrinsic-like subtypes are n…
View article: Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer
Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer Open
The breast cancer risk conferred by germline protein truncating variants (PTVs) in known and putative breast cancer genes has been extensively investigated. However, the effect of FANCM PTVs on breast cancer risk remains unclear. Our previ…
View article: Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer
Exogenous Hormones, Tumor Intrinsic Subtypes, and Breast Cancer Open
Importance Etiologic heterogeneity in breast carcinogenesis needs to be well characterized for targeted prevention. Associations between menopausal hormonal therapy (MHT) and oral contraceptive (OC) use and breast cancer intrinsic-like sub…
View article: Mammographic density, pathogenic breast cancer susceptibility gene variants and breast cancer risk
Mammographic density, pathogenic breast cancer susceptibility gene variants and breast cancer risk Open
Importance Mammographic density (MD) and pathogenic variants (PVs) in breast cancer susceptibility genes are major determinants of breast cancer risk, but their association and joint effects on breast cancer risk are unclear. Objective To …
View article: Interactions between genetic and epidemiological factors influencing mammographic density
Interactions between genetic and epidemiological factors influencing mammographic density Open
Studies have identified genetic and epidemiologic factors associated with mammographic density (MD) phenotypes. However, MD-associated genetic variants only account for a small proportion of the total estimated heritability. Interrogating …
View article: Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer: prospective study of asymptomatic and symptomatic UK Biobank participants
Genetics, primary care records and lifestyle factors for short-term dynamic risk prediction of colorectal cancer: prospective study of asymptomatic and symptomatic UK Biobank participants Open
Objectives To quantify the contributions of polygenic scores, primary care records (presenting symptoms, medical history and common blood tests) and lifestyle factors, for short-term risk prediction of colorectal cancer (CRC) in general an…
View article: Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia
Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia Open
BACKGROUND: Expansion of genome-wide association studies across population groups is needed to improve our understanding of shared and unique genetic contributions to breast cancer. We performed association and replication studies guided b…
View article: Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank
Using Family History Data to Improve the Power of Association Studies: Application to Cancer in UK Biobank Open
In large cohort studies the number of unaffected individuals outnumbers the number of affected individuals, and the power can be low to detect associations for outcomes with low prevalence. We consider how including recorded family history…
View article: Evaluating the performance of the Breast and Ovarian Analysis of Disease Incidence Algorithm model in predicting 10-year breast cancer risks in UK Biobank
Evaluating the performance of the Breast and Ovarian Analysis of Disease Incidence Algorithm model in predicting 10-year breast cancer risks in UK Biobank Open
Background The Breast and Ovarian Analysis of Disease Incidence Algorithm (BOADICEA) model predicts breast cancer risk using cancer family history, epidemiological, and genetic data. We evaluated its validity in a large prospective cohort.…
View article: Childhood, adolescent, and young adulthood cancer risk in <i>BRCA1</i> or <i>BRCA2</i> pathogenic variant carriers
Childhood, adolescent, and young adulthood cancer risk in <i>BRCA1</i> or <i>BRCA2</i> pathogenic variant carriers Open
Background Whether carriers of BRCA1 or BRCA2 pathogenic variants have increased risks of childhood, adolescent, and young adult cancers is controversial. We aimed to evaluate this risk and to inform clinical care of young BRCA1 and BRCA2 …
View article: National-Scale Optimized Design of Cost-Effective Water Supply and Transfer Systems
National-Scale Optimized Design of Cost-Effective Water Supply and Transfer Systems Open
Many countries contain some regions with water surpluses and others with deficits, and with differences in the marginal cost of future water supply development. These factors imply to some extent an opportunity to attain or maintain water …
View article: Supplementary Table S2 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Supplementary Table S2 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Supplementary Table S2 show the country in which the studies were conducted
View article: Supplementary Table S1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Supplementary Table S1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Supplementary Table S1 shows studies and samples used in these analyses
View article: Data from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Data from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Background:The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast can…
View article: Figure 1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Figure 1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Graph of BOADICEA parameter alpha (αRL) versus log-OR per 1 SD. Graph of BOADICEA parameter alpha (αRL) versus log-OR per 1 SD for PRS313 and alternative PRS. αRL were estimated using the retrospective likelihood method as described in Mat…
View article: Table 1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Table 1 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Summary parameters for alternative PRSs.a
View article: Supplementary Methods from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Supplementary Methods from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Supplementary Methods provides details of methodology
View article: Supplementary Table S3 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Supplementary Table S3 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Supplementary Table S3 shows SNPs and weights for the BCAC PRS313.
View article: Supplementary Table S4 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model
Supplementary Table S4 from Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model Open
Supplementary Table S4shows SNPs and weights used in the alternative PRS.