Explanipedia

The Impact of Raising the Hypoglycemia Critical Value Alert Threshold at an Academic Medical Center Open

Stephanie A Hart, Scott D. Nelson, Ryan F Schell, Joesph R Wiencek · 2025

376 Validation of the Lidocaine Syva EMIT™ Assay on the Roche cobas 503 System Open

Mary A. Hood, Joesph R Wiencek · 2025

Introduction/Objective Lidocaine is a class IB antiarrhythmic with a narrow therapeutic index. The lidocaine Syva EMIT™ is a third-party FDA-approved assay adaptable to several automated chemistry platforms. Although assay parameters exist…

Potential savings of two practical interventions on vitamin D ordering practices at a large academic medical center Open

Stephanie A Hart, Jeremy Brown, Joesph R Wiencek · 2025

Estimated waste generation from 1 million basic metabolic panels: a multisite U.S. study Open

Seema Khattri Bhandari, Kwaku Twum, Erving T Laryea, Yaqing Du, Raeshun T Glover , et al. · 2025

Objectives Clinical laboratory operations consume large amounts of electricity and water and generate considerable quantities of solid waste. In this study, we quantified and compared the estimated solid waste produced from performing one …

Ethical Checklists for Clinical Research Projects and Laboratory Medicine: two tools to evaluate compliance with bioethical principles in different settings Open

Julián Verona, Gülşen Yılmaz, Martina Zaninotto, Sody Munsaka, Nafija Serdarević , et al. · 2024

Objectives To develop two ethical checklists to evaluate (i) management of ethical concerns in research projects and (ii) awareness of ethical conduct of healthcare laboratory professionals. Methods Comprehensive discussion among the membe…

Tennessee hospital noncompliance with price transparency legislation for 8 common laboratory tests Open

Stephanie A Hart, Ayesha Khan, Garrett S. Booth, Joesph R Wiencek · 2024

Objectives The goal of this study was to assess hospital compliance with federal price transparency mandates and barriers to pricing information in Tennessee. Methods All hospitals websites were queried for gross, cash, and BlueCross BlueS…

Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response Open

Y. Victoria Zhang, Attila Kumánovics, Joesph R Wiencek, Stacy E.F. Melanson, Tanzy Love , et al. · 2024

This study aimed to evaluate and compare the performance of three anti-S and one anti-N assays that were available to the project in detecting antibody levels after three commonly used SARS-CoV-2 vaccines (Pfizer, Moderna, and Johnson & Jo…

Recycling Opportunities in a High Volume Academic Clinical Chemistry Laboratory Open

Raeshun T Glover, Garrett S. Booth, Joesph R Wiencek · 2023

Many sectors of industry, including the biomedical sector, have quantified waste, and created sustainability strategies to mitigate its environmental impact. One of these strategies utilizes the waste hierarchy, a model which ranks the con…

Analytical Performance Evaluation of BioRad’s Unassayed Multiqual, Immunoassay Plus and Assayed Multiqual InteliQ Tube-Based Quality Control Materials Open

Erving T Laryea, Kelsey Mitchell, E. C. C. Standford, Julia Álvarez Hernández, Joesph R Wiencek · 2023

Introduction Quality control (QC) practices commonly require aliquoting of liquid material into sample cups prior to analysis. Recently, newer tube-based QC has become available that can be scanned directly onto the analyzer without additi…

Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization Open

Nicole V. Tolan, Matthew D. Krasowski, Patrick C. Mathias, Joesph R Wiencek, Nikolina Babić , et al. · 2023

States may experience an increase in cannabis-related emergency department visits with progression toward marijuana legalization. The differences between states, including those in which no impact was seen, are likely multifactorial and in…

T Cell Responses Correlate with Self-Reported Disease Severity and Neutralizing Antibody Responses Predict Protection against SARS-CoV-2 Breakthrough Infection Open

Zhen Zhao, Attila Kumánovics, Tanzy Love, Stacy E.F. Melanson, Qing H. Meng , et al. · 2023

Objectives: The objective of this prospective study was to investigate the role of adaptive immunity in response to SARS-CoV-2 vaccines. Design and Methods: A cohort of 677 vaccinated individuals participated in a comprehensive survey of t…

A Pediatric Patient with a Complicated History of Sickle Cell Trait Open

Elena Nedelcu, Joesph R Wiencek, Christina C. Pierre · 2022

Journal Article A Pediatric Patient with a Complicated History of Sickle Cell Trait Get access Elena Nedelcu, Elena Nedelcu Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USAPathology, Microbi…

Tolerance for three commonly administered COVID-19 vaccines by healthcare professionals Open

Stacy E.F. Melanson, Zhen Zhao, Attila Kumánovics, Tanzy Love, Qing H. Meng , et al. · 2022

Importance Most healthcare institutions require employees to be vaccinated against SARS-CoV-2 and many also require at least one booster. Objective We determine the impact of vaccine type, demographics, and health conditions on COVID-19 va…

A Paradigm Shift: Engagement of Clinical Chemistry and Laboratory Medicine Trainees by Innovative Teaching Methods Open

Joesph R Wiencek, Allison B Chambliss, Roger L. Bertholf, Steven W. Cotten, Christina Ellervik , et al. · 2022

The Utility of PathElective.com as a Curricular Adjunct in Laboratory Medicine Education Open

Cullen M. Lilley, Maximo J Marin, Joesph R Wiencek, Longwen Fu, Kristy Wolniak , et al. · 2021

Introduction/Objective PathElective.com was founded as a means of combating stagnating resident and medical student education due to halting of in-person educational activities during the COVID-19 pandemic. The site has since grown to be i…

AACC Practical Recommendations for Implementing and Interpreting SARS-CoV-2 Emergency Use Authorization and Laboratory-Developed Test Serologic Testing in Clinical Laboratories Open

Y Victoria Zhang, Joesph R Wiencek, Qing H. Meng, Elitza S. Theel, Nikolina Babić , et al. · 2021

Background The clinical laboratory continues to play a critical role in managing the coronavirus pandemic. Numerous US Food and Drug Administration emergency use authorization (EUA) and laboratory-developed test (LDT) serologic assays have…

Cross-Institutional Evaluation of the Abbott ARCHITECT SARS-CoV-2 IgG Immunoassay Open

Joesph R Wiencek, Lorin M Bachmann, Kelly Dinwiddie, Greg Miller, Lindsay Bazydlo · 2021

Objective To describe a cross-institutional approach to verify the Abbott ARCHITECT SARS-CoV-2 antibody assay and to document the kinetics of the serological response. Methods We conducted analytical performance evaluation studies using th…

Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP Open

Behnam Keshavarz, Joesph R Wiencek, Lisa J. Workman, Matthew Straesser, Lyndsey M. Muehling , et al. · 2021

Background: Detailed understanding of the immune response to severe acute respiratory syndrome coronavirus (SARS-CoV)-2, the cause of coronavirus disease 2019 (COVID-19) has been hampered by a lack of quantitative antibody a…

Quantitative measurement of IgG to SARS-CoV-2 proteins using ImmunoCAP Open

Behnam Keshavarz, Joesph R Wiencek, Lisa J. Workman, Matthew Straesser, Lyndsey M. Muehling , et al. · 2020

Background Detailed understanding of the immune response to SARS-CoV-2, the cause of coronavirus disease 2019 (COVID-19), has been hampered by a lack of quantitative antibody assays. Objective To develop a quantitative assay for IgG to SAR…

Clinical Ordering Practices of the SARS-CoV-2 Antibody Test at a Large Academic Medical Center Open

Joesph R Wiencek, Carter L Head, Costi D. Sifri, Andrew S. Parsons · 2020

Background The novel severe acute respiratory coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) originated in December 2019 and has now infected almost 5 million people in the United States. In the spring of 2020, …

Clinical Ordering Practices of the SARS-CoV-2 Antibody Test at a Large Academic Medical Center Open

Joesph R Wiencek, Carter L Head, Costi D. Sifri, Andrew S. Parsons · 2020

Background: The novel severe acute respiratory coronavirus 2 (SARS-CoV-2) that causes COVID-19 originated in December 2019 and has now infected over 3 million people in the United States. In Spring of 2020, private laboratories and some ho…

A Deep C Dive Open

Jennifer Y. Ju, Joesph R Wiencek · 2020

Challenges in the Assessment and Diagnosis of Polycystic Ovary Syndrome Open

Joesph R Wiencek, Christopher R. McCartney, Alice Y. Chang, Joely A. Straseski, Richard J. Auchus , et al. · 2019

Polycystic ovary syndrome (PCOS)7 is a complex endocrine-mediated disorder in women with a prevalence of 8% to 13%. Women with PCOS typically present with heterogeneous clinical signs and symptoms such as excess hair growth, irregular mens…

Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood Open

Joesph R Wiencek, Eric A. Gehrie, Amaris Keiser, Penny C. Szklarski, Kamisha L. Johnson‐Davis , et al. · 2018

Objectives To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool. Methods Segments from 105 RBC units were tested for the pre…

Persistently Increased Alloisoleucine in a Patient with Seizures Open

Joesph R Wiencek, Dennis J. Dietzen, Teresa A. Murray, Sheila Dawling, Jennifer M. Colby , et al. · 2018

A 3-year-old female presented to the emergency department with worsening myoclonic and atonic seizures. Several months before presentation, she was diagnosed with epilepsy and was treated with an antiepileptic medication (zonisamide, 10 g/…

Impact of Ambient Seasonal Temperature on Specimens Stored in Courier Lockboxes Open

Joesph R Wiencek, James H. Nichols · 2018

To the Editor: Storage lockboxes for patient specimens are commonly used by reference and referral laboratories. Blood samples collected at outpatient clinics are typically separated into plasma and serum by centrifugation, and then store…

DNA Sequencing in the Clinical Laboratory: A Ladder to the Future Open

Sean Campbell, Joesph R Wiencek · 2018

In a matter of 4 decades, the landscape of genetic sequencing has evolved dramatically. Through technological advancements and substantial decreases in costs, DNA sequencing has progressed from a nascent research tool that costs hundreds o…

Advances in the Diagnosis and Management of Cystic Fibrosis in the Genomic Era Open

Joesph R Wiencek, Stanley F. Lo · 2018

BACKGROUND Cystic fibrosis (CF) is a complex autosomal recessive disease that continues to present unique diagnostic challenges. Because CF was first described in 1938, there has been a substantial growth of genetic and phenotypic informat…

A Primed Hemoglobinopathy Screen Open

Joesph R Wiencek, Garrett S. Booth, James H. Nichols · 2017

A 27-year-old African American gravida 1 para 0 woman submitted a sample for hemoglobin (Hb)3 evaluation as recommended by the American College of Obstetricians and Gynecologists (ACOG) (1). The analysis performed by the Bio-Rad Variant II…

Falsely Decreased Carbon Dioxide in Patients with Hypertriglyceridemia Open

Joesph R Wiencek, Christopher Bowman, Brad Adams, Craig Sussman, Gregory C. Sephel , et al. · 2017

To the Editor: Lipemia is a complex interferant in clinical laboratory testing (1). Turbidity caused by increased VLDL and chylomicrons scatters light in spectrophotometric-based methods (2, 3). To address this issue, analyzer and reagent…

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