Explanipedia

Characterization of age-dependent changes to hemodynamics and thymocyte motility in the native thymus after SL-TBI using two-photon intravital microendoscopy 4457 Open

Christian Burns, Joel A. Spencer · 2025

Description The thymus, as the primary site of T cell maturation, plays a critical role in the functionality of the adaptive immune system, and as such, the recovery of the thymus after injury and the role that the thymus vasculature syste…

Abstract 2715 The Effects of Von Hippel-Lindau (Vhl) Gene Knockout on Bone Marrow Microenvironmets and B cell Development Open

Christelle Baria, Joel A. Spencer, Jennifer O. Manilay · 2025

Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool Open

Dorsa Toghani, S. Gupte, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse , et al. · 2024

SUMMARY Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased HSC (myHSC) are indispensable for repl…

Age and dose dependent changes to the bone and bone marrow microenvironment after cytotoxic conditioning with busulfan Open

Nastaran Abbasizadeh, Christian Burns, Ruth Verrinder, Farhad Ghazali, Negar Seyedhassantehrani , et al. · 2024

Preparative regimens before Hematopoietic Cell Transplantation (HCT) damage the bone marrow (BM) microenvironment, potentially leading to secondary morbidity and even mortality. The precise effects of cytotoxic preconditioning on bone and …

Intravital Two-Photon Microscopy of the Native Thymus Open

Negar Seyedhassantehrani, Christian Burns, Ruth Verrinder, Victoria Okafor, Nastaran Abbasizadeh , et al. · 2023

The thymus, a key organ involved in the adaptive immune system, is damaged by a variety of insults including cytotoxic preconditioning. This damage can lead to atrophy and potentially to changes in the hemodynamics of the thymic blood vasc…

Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing Open

Tomer Itkin, Sean Houghton, Ryan Schreiner, Lin Yang, Chaitanya R. Badwe , et al. · 2023

Transition between activation and quiescence programs in hematopoietic stem and progenitor cells (HSC/HSPCs) is perceived to be governed intrinsically and by microenvironmental co-adaptation. However, HSC programs dictating both transition…

Thymic mesenchymal niche cells drive T cell immune regeneration Open

Karin Gustafsson, Sergey Isaev, Kameron Kooshesh, Ninib Baryawno, Konstantinos D. Kokkaliaris , et al. · 2022

Thymic atrophy and the progressive immune decline that accompanies it is a major health problem, chronically with age and acutely with immune injury. No solution has been defined. Here we demonstrate that one of the three mesenchymal cell …

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence Open

Dorsa Toghani, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani , et al. · 2022

SUMMARY Tissue stem cells are hierarchically organized. Those that are most primitive serve as key drivers of regenerative response but the signals that selectively preserve their functional integrity are largely unknown. Here, we identify…

Myeloid-Biased HSC Require Semaphorin 4A From the Bone Marrow Niche for Self-Renewal Under Stress and Life-Long Persistence Open

Dorsa Toghani, Sharon Zeng, Elmir Mahammadov, Edie I. Crosse, Negar Seyedhassantehrani , et al. · 2022

Deletion of<i>Vhl</i>in<i>Dmp1</i>-expressing cells causes microenvironmental impairment of B cell lymphopoiesis Open

Betsabel Chicana, Nastaran Abbasizadeh, Christian Burns, Hanna Taglinao, Joel A. Spencer , et al. · 2021

The contributions of skeletal cells to the processes of B cell development in the bone marrow (BM) have not been completely described. The von-Hippel Lindau protein (VHL) plays a key role in cellular responses to hypoxia. Previous work sho…

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML Open

Toshihiko Oki, François Mercier, Hiroki Kato, Yookyung Jung, Thomas O. McDonald , et al. · 2021

Live-animal imaging of native haematopoietic stem and progenitor cells Open

Constantina Christodoulou, Joel A. Spencer, Shu‐Chi A. Yeh, Raphaël Turcotte, Konstantinos D. Kokkaliaris , et al. · 2020

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors Open

Jungmin Lee, Brad Dykstra, Joel A. Spencer, Laurie L. Kenney, Dale L. Greiner , et al. · 2017

Generation of functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (PSCs) has been a long-sought-after goal for use in hematopoietic cell production, disease modeling, and eventually transplantation …

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators Open

Lev Silberstein, Ana Katherine Gonçalves, Peter V. Kharchenko, Raphaël Turcotte, Youmna Kfoury , et al. · 2016

Erratum: Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis Open

Tomer Itkin, Shiri Gur‐Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy , et al. · 2016

Distinct bone marrow blood vessels differentially regulate haematopoiesis Open

Tomer Itkin, Shiri Gur‐Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy , et al. · 2016

Analyzing Structure and Function of Vascularization in Engineered Bone Tissue by Video-Rate Intravital Microscopy and 3D Image Processing Open

Yonggang Pang, Olga Tsigkou, Joel A. Spencer, Charles P. Lin, Craig M. Neville , et al. · 2015

Vascularization is a key challenge in tissue engineering. Three-dimensional structure and microcirculation are two fundamental parameters for evaluating vascularization. Microscopic techniques with cellular level resolution, fast continuou…

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