Joel Bozekowski
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View article: High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells Open
T follicular helper (T FH ) cells are the conventional drivers of protective, germinal center (GC)–based antiviral antibody responses. However, loss of T FH cells and GCs has been observed in patients with severe COVID-19. As T cell–B cell…
View article: High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19
High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19 Open
View article: High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells
High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells Open
T follicular helper (Tfh) cells are the conventional drivers of protective, germinal center (GC)-based antiviral antibody responses. However, loss of Tfh cells and GCs has been observed in patients with severe COVID-19. As T cell-B cell in…
View article: Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine
Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine Open
Previous herpes simplex virus type 2 (HSV-2) vaccines have not prevented genital herpes. Concerns have been raised about the choice of antigen, the type of antibody induced by the vaccine, and whether antibody is present in the genital tra…
View article: High-resolution mapping and characterization of epitopes in COVID-19 patients
High-resolution mapping and characterization of epitopes in COVID-19 patients Open
Fine scale delineation of epitopes recognized by the antibody response to SARS-CoV-2 infection will be critical to understanding disease heterogeneity and informing development of safe and effective vaccines and therapeutics. The Serum Epi…
View article: Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format
Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format Open
Widely employed diagnostic antibody serology for Lyme disease, known as standard two-tier testing (STTT), exhibits insufficient sensitivity in early Lyme disease, yielding many thousands of false-negative test results each year. Given this…
View article: A general approach for predicting protein epitopes targeted by antibody repertoires using whole proteomes
A general approach for predicting protein epitopes targeted by antibody repertoires using whole proteomes Open
Antibodies are essential to functional immunity, yet the epitopes targeted by antibody repertoires remain largely uncharacterized. To aid in characterization, we developed a generalizable strategy to predict antibody-binding epitopes withi…
View article: A general approach for identifying protein epitopes targeted by antibody repertoires using whole proteomes
A general approach for identifying protein epitopes targeted by antibody repertoires using whole proteomes Open
Antibodies are essential to functional immunity, yet the epitopes targeted by antibody repertoires remain largely uncharacterized. To aid in characterization, we developed a generalizable strategy to identify antibody-binding epitopes with…
View article: High-titer antibody depletion enhances discovery of diverse serum antibody specificities
High-titer antibody depletion enhances discovery of diverse serum antibody specificities Open
The human antibody repertoire is a unique repository of information regarding infection, inflammation, and autoimmunity of the past, present, and future. However, antibodies can span vast ranges of concentrations with varying affinities an…
View article: Serum antibody repertoire analysis for high-throughput epitope discovery and characterization
Serum antibody repertoire analysis for high-throughput epitope discovery and characterization Open
The serum antibody repertoire is a unique repository of information regarding past immune encounters. Antibodies are produced in response to exposures and bind specifically to their target antigens. Antibodies associated with infection and…
View article: Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing
Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing Open