Joel D. Cooper
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View article: The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD
The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in COPD Open
Rationale Peripheral airway obstruction is a key feature of chronic obstructive pulmonary disease (COPD), but the mechanisms of airway loss are unknown. This study aims to identify the molecular and cellular mechanisms associated with peri…
View article: The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF)
The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF) Open
The transition from normal lung anatomy to minimal and established fibrosis is associated with genes that are involved in the tissue repair processes, the activation of immune responses as well as the increased infiltration of CD4, CD8, B …
View article: Real-Time Prediction of Short Time Scale Fluctuations in Cognitive Workload
Real-Time Prediction of Short Time Scale Fluctuations in Cognitive Workload Open
Human operators often experience large fluctuations in cognitive workload over seconds time scales that can lead to sub-optimal performance, ranging from overload to neglect. Adaptive automation could potentially address this issue, but to…
View article: Comprehensive stereological assessment of the human lung using multiresolution computed tomography
Comprehensive stereological assessment of the human lung using multiresolution computed tomography Open
Stereology has been the gold standard to quantify the three-dimensional lung anatomy using two-dimensional microscopy images. However, such techniques are labor intensive. This study provides a method that applies stereology to volumetric …
View article: Manipulation and Patterning of Mammalian Cells Using Vibrations and Acoustic Forces
Manipulation and Patterning of Mammalian Cells Using Vibrations and Acoustic Forces Open
Recently, there has been a surge in researchers and scientists investigating different methods which move, manipulate, and pattern biological cells. Multiple different mechanisms can be used for cellular manipulation, microfluidics, bioche…
View article: Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue
Nondestructive cryomicro-CT imaging enables structural and molecular analysis of human lung tissue Open
Micro-computed tomography (CT) enables three-dimensional (3D) imaging of complex soft tissue structures, but current protocols used to achieve this goal preclude cellular and molecular phenotyping of the tissue. Here we describe a radioluc…
View article: Table of Contents
Table of Contents Open
The address represents the culmination of extensive research, multiple expert opinions from a range of relevant fields
View article: Surgery of the airway: historic notes.
Surgery of the airway: historic notes. Open
Prior to the 20(th) century, the need for surgical procedures on the airway was infrequent and consisted mainly of tracheostomy to relieve airway obstruction or repair of tracheal injuries such as lacerations. Even the ability of tracheal …
View article: Morphometric Analysis of Explant Lungs in Cystic Fibrosis
Morphometric Analysis of Explant Lungs in Cystic Fibrosis Open
Extensive changes of dilatation and obstruction in nearly all airway generations were observed in end-stage CF lung disease.
View article: Linking clinical phenotypes of chronic lung allograft dysfunction to changes in lung structure
Linking clinical phenotypes of chronic lung allograft dysfunction to changes in lung structure Open
Chronic lung allograft dysfunction (CLAD) remains the major barrier to long-term success after lung transplantation. This report compares gross and microscopic features of lungs removed from patients receiving a redo-transplant as treatmen…
View article: Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease
Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease Open
These results support the hypothesis that there is a host immune response to microorganisms within the lung microbiome that appears to contribute to the pathogenesis of COPD.