Joel G. Wright
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View article: Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors
Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors Open
Optofluidic biosensors have become an important medical diagnostic tool because they allow for rapid, high-sensitivity testing of small samples compared to standard lab testing. For these devices, the practicality of use in a medical setti…
View article: Performance Comparison of Flow-Through Optofluidic Biosensor Designs
Performance Comparison of Flow-Through Optofluidic Biosensor Designs Open
Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), a…
View article: Optofluidic Flow-Through Biosensor Sensitivity – Model and Experiment
Optofluidic Flow-Through Biosensor Sensitivity – Model and Experiment Open
We present a model and simulation for predicting the detected signal of a fluorescence-based optical biosensor built from optofluidic waveguides. Typical applications include flow experiments to determine pathogen concentrations in a biolo…
View article: Greatly Enhanced Single Particle Fluorescence Detection Using High Refractive Index Liquid-Core Waveguides
Greatly Enhanced Single Particle Fluorescence Detection Using High Refractive Index Liquid-Core Waveguides Open
High sensitivity and easy integration with microfabrication techniques has made silicon photonics one of the leading technologies used to build biosensors for diagnostic applications. Here we introduce a new silicon dioxide based optofluid…
View article: Effects of Post-Etch Microstructures on the Optical Transmittance of Silica Ridge Waveguides
Effects of Post-Etch Microstructures on the Optical Transmittance of Silica Ridge Waveguides Open
Silica waveguides are often etched by reactive ion etch (RIE) processes. These processes can leave residual topography that can increase optical loss. We investigated the relation between optical loss and various RIE etch. A wet etch step …
View article: 3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer
3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer Open
Optofluidic devices are capable of detecting single molecules, but greater sensitivity and specificity is desired through hydrodynamic focusing (HDF). Three-dimensional (3D) hydrodynamic focusing was implemented in 10-μm scale microchannel…