Explanipedia

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference Open

Kelli L. Hvorecny, Tim S. Veth, Pavel Aprikian, Anna A. Manchenko, Veronika Tchesnokova , et al. · 2025

A critical step in infections is the attachment of microorganisms to host cells using lectins that bind glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, an adhesin in E. coli, undergoes an a…

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals Open

Risako Gen, Amin Addetia, Daniel Asarnow, Young‐Jun Park, Joel Quispe , et al. · 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, esp…

AlMnPdPtAu Quasicrystal Modulated Carbon Nanotubes for H<sub>2</sub> Sensors: Experimental and DFT Computational Analysis Open

Sumit Kumar, Anyesha Chakraborty, Joel Quispe, Rahul Mitra, Suraj Barala , et al. · 2025

Hydrogen (H₂) sensors are crucial for safety in H₂ storage and fuel cell systems. AlMnPdPtAu high-entropy alloy (HEA) quasicrystal nanosheets with high surface area, tunable electronic structure, and atomic disorder e…

SARS-CoV-2 nsp1 mediates broad inhibition of translation in mammals Open

Risako Gen, Amin Addetia, Daniel Asarnow, Young‐Jun Park, Joel Quispe , et al. · 2025

SARS-CoV-2 nonstructural protein 1 (nsp1) promotes innate immune evasion by inhibiting host translation in human cells. However, the role of nsp1 in other host species remains elusive, especially in bats which are natural reservoirs of sar…

Probing the Chemical Interaction of Neurotransmitter (Gaba: Γ-Aminobutyric Acid) with Two-Dimensional Cobalt Telluride Open

Anyesha Chakraborty, Joel Quispe, Solomon Demiss Negedu, Suman Sarkar, Prikshat Dadhwal , et al. · 2025

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference Open

Kelli L. Hvorecny, Gianluca Interlandi, Tim S. Veth, Pavel Aprikian, Anna Manchenko , et al. · 2024

A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, the most studied lectin …

Isolation and escape mapping of broadly neutralizing antibodies against emerging delta-coronaviruses Open

Megi Rexhepaj, Daniel Asarnow, Lisa Perruzza, Young‐Jun Park, Barbara Guarino , et al. · 2024

Porcine delta-coronavirus (PDCoV) spillovers were recently detected in febrile children, underscoring the recurrent zoonoses of divergent CoVs. To date, no vaccines or specific therapeutics are approved for use in humans against PDCoV. To …

Broadly neutralizing antibodies against emerging delta-coronaviruses Open

Megi Rexhepaj, Young‐Jun Park, Lisa Perruzza, Daniel Asarnow, Matthew McCallum , et al. · 2024

Porcine deltacoronavirus (PDCoV) spillovers were recently detected in children with acute undifferentiated febrile illness, underscoring recurrent zoonoses of divergent coronaviruses. To date, no vaccines or specific therapeutics are appro…

Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly Open

S. John Calise, Audrey G. O’Neill, Anika L. Burrell, Miles Sasha Dickinson, Josephine Molfino , et al. · 2024

Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in guanosine triphosphate (GTP) synthesis and assembles into filaments in cells, which desensitizes the enzyme to feedback inhibition and boosts nucleotide production.…

Hiding Encrypted Images in Audios Based on Cellular Automatas and Discrete Fourier Transform Open

José Cornejo, Esdras D. Vasquez, Joel Quispe, Roxana Flores-Quispe, Yuber Velazco-Paredes · 2024

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus Open

Jimin Lee, Samantha K. Zepeda, Young‐Jun Park, Ashley L. Taylor, Joel Quispe , et al. · 2023

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants Open

S. John Calise, Audrey G. O’Neill, Anika L. Burrell, Miles Sasha Dickinson, Josephine Molfino , et al. · 2023

Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in de novo guanosine triphosphate (GTP) synthesis and is controlled by feedback inhibition and allosteric regulation. IMPDH assembles into micron-scale filaments in ce…

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus Open

Jimin Lee, Samantha K. Zepeda, Young‐Jun Park, Ashley L. Taylor, Joel Quispe , et al. · 2023

Although Rhinolophus bats harbor diverse clade 3 sarbecoviruses, the structural determinants of receptor tropism along with the antigenicity of their spike (S) glycoproteins remain uncharacterized. Here, we show that the African Rinolophus…

Neutralization, effector function and immune imprinting of Omicron variants Open

Amin Addetia, Luca Piccoli, James Brett Case, Young‐Jun Park, Martina Beltramello , et al. · 2023

Human PRPS1 filaments stabilize allosteric sites to regulate activity Open

Kelli L. Hvorecny, Kenzee Hargett, Joel Quispe, Justin M. Kollman · 2023

Abstract 2586: Light-sensitive phosphorylation regulates feedback inhibition and filament assembly of human IMPDH1 retinal splice variants Open

S.John Calise, Audrey O’Neill, Anika L. Burrell, Charlie Clarke, Josephine Molfino , et al. · 2023

Human PRPS1 filaments stabilize allosteric sites to regulate activity Open

Kelli L. Hvorecny, Kenzee A. Hargett, Joel Quispe, Justin M. Kollman · 2022

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a sp…

Computational design of mechanically coupled axle-rotor protein assemblies Open

Alexis Courbet, Jesse M. Hansen, Yang Hsia, Neville P. Bethel, Young‐Jun Park , et al. · 2022

Natural molecular machines contain protein components that undergo motion relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstanding challenge for comp…

IMPDH1 retinal variants control filament architecture to tune allosteric regulation Open

Anika L. Burrell, Chuankai Nie, Meerit Y. Said, Jacqueline C. Simonet, David Fernández‐Justel , et al. · 2022

Computational design of nanoscale rotational mechanics in <i>de novo</i> protein assemblies Open

Alexis Courbet, Jesse M. Hansen, Yang Hsia, Neville P. Bethel, YJ. Park , et al. · 2021

Natural nanomachines like the F 1 /F 0 -ATPase contain protein components that undergo rotation relative to each other. Designing such mechanically constrained nanoscale protein architectures with internal degrees of freedom is an outstand…

Author response: Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation Open

Jesse M. Hansen, Avital Horowitz, Eric M. Lynch, Daniel P. Farrell, Joel Quispe , et al. · 2021

Structural basis for isoform-specific inhibition of human CTPS1 Open

Eric M. Lynch, Michael A. DiMattia, Steven K. Albanese, Gydo C. P. van Zundert, Jesse M. Hansen , et al. · 2021

Significance An effective immune response depends on the proliferation of T cells, a process that requires the enzyme CTP synthase 1 (CTPS1). Individuals lacking CTPS1 due to a rare genetic disorder exhibit severe immunodeficiencies but la…

Cryo-EM Structures of CTP Synthase Filaments Reveal Mechanism of pH-Sensitive Assembly During Budding Yeast Starvation Open

Jesse M. Hansen, Avital Horowitz, Eric M. Lynch, Daniel P. Farrell, Joel Quispe , et al. · 2021

Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cyto…

IMPDH1 retinal variants control filament architecture to tune allosteric regulation Open

Anika L. Burrell, Chuankai Nie, Meerit Y. Said, Jacqueline C. Simonet, David Fernández‐Justel , et al. · 2021

IMP dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in metabolic demand. Humans have two isoforms: IMPDH2 filaments reduce sensitivity to feedback inh…

Structural basis for broad coronavirus neutralization Open

Maximilian M. Sauer, M. Alejandra Tortorici, Young‐Jun Park, Alexandra C. Walls, Leah J. Homad , et al. · 2021

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM Open

Betty Shen, Joel Quispe, Yvette A. Luyten, Benjamin E. McGough, Richard Morgan , et al. · 2021

Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM Open

Betty Shen, Joel Quispe, Yvette A. Luyten, Benjamin E. McGough, Richard Morgan , et al. · 2021

Restriction enzymes that combine DNA methylation and cleavage activities into a single polypeptide or protein assemblage and that modify just one DNA strand for host protection are capable of more efficient adaptation towards novel target …

Structural basis for broad coronavirus neutralization Open

Maximilian M. Sauer, Marcello Tortorici, Young‐Jun Park, Alexandra C. Walls, Leah J. Homad , et al. · 2020

Three highly pathogenic β-coronaviruses crossed the animal-to-human species barrier in the past two decades: SARS-CoV, MERS-CoV and SARS-CoV-2. SARS-CoV-2 has infected more than 64 million people worldwide, claimed over 1.4 million lives a…

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion Open

Alexandra C. Walls, Xiaoli Xiong, Young‐Jun Park, M. Alejandra Tortorici, Joost Snijder , et al. · 2020

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion Open

Alexandra C. Walls, Xiaoli Xiong, Young‐Jun Park, M. Alejandra Tortorici, Joost Snijder , et al. · 2019

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