Joel P. Schneider
YOU?
Author Swipe
View article: <i>Id1</i> promotes clonal hematopoiesis in mice with <i>Tet2</i> loss of function
<i>Id1</i> promotes clonal hematopoiesis in mice with <i>Tet2</i> loss of function Open
Hematopoietic malignancies emerge through the acquisition of genetic mutations within hematopoietic stem and progenitor cells (HSPCs). Some mutations impart a selective growth advantage to HSPCs, which expand and contribute to mature blood…
View article: Antibody Labeling With FITC Facilitates Controlled Release From Peptide Hydrogels Bearing Fc‐Binding Motifs
Antibody Labeling With FITC Facilitates Controlled Release From Peptide Hydrogels Bearing Fc‐Binding Motifs Open
Controlled release systems can enhance the efficacy of therapeutic antibodies, particularly for subcutaneous delivery where high or frequent doses are needed. Herein, we designed a peptide hydrogel that displays the binding motif HWRGWV, w…
View article: Elucidation and prevention of an unexpected methylamine byproduct formed during trifluoroacetic acid-mediated side chain deprotection of azido-containing peptides
Elucidation and prevention of an unexpected methylamine byproduct formed during trifluoroacetic acid-mediated side chain deprotection of azido-containing peptides Open
Purpose We found that during TFA-mediated cleavage of azide-containing peptides during solid-phase peptide synthesis a byproduct characterized by a difference of 12 mass units is formed. This study identifies this byproduct, provides a rat…
View article: Modulating Neutrophil Extracellular Trap Formation <i>In Vivo</i> with Locoregional Precision Using Differently Charged Self-Assembled Hydrogels
Modulating Neutrophil Extracellular Trap Formation <i>In Vivo</i> with Locoregional Precision Using Differently Charged Self-Assembled Hydrogels Open
Neutrophil extracellular traps (NETs) are DNA networks released by neutrophils, first described as a defense response against pathogens but have since been associated with numerous inflammatory diseases. Diverse physical material propertie…
View article: Exploring the temperature dependence of β-hairpin peptide self-assembly
Exploring the temperature dependence of β-hairpin peptide self-assembly Open
Herein, we study the role that hydrophobicity plays in the temperature-dependent self-assembly of a family of β-hairpin peptide amphiphiles through the lens of thermally folding a protein from its cold-denatured state.
View article: Creating better internships by understanding mentor challenges: findings from a series of focus groups
Creating better internships by understanding mentor challenges: findings from a series of focus groups Open
View article: <i>Id1</i>Promotes Clonal Hematopoiesis in Mice with<i>Tet2</i>Loss of Function
<i>Id1</i>Promotes Clonal Hematopoiesis in Mice with<i>Tet2</i>Loss of Function Open
Hematopoietic malignancies emerge through the gradual acquisition of genetic mutations within hematopoietic stem and progenitor cells (HSPCs). Mutations that occur early in disease progression impart a selective growth advantage to HSPCs, …
View article: “It's been a Process”: A Multiple Case Study of Biology Instructor Efforts to Reform their Sex and Gender Curriculum to be More Inclusive of Students with Queer Genders and Intersex Students
“It's been a Process”: A Multiple Case Study of Biology Instructor Efforts to Reform their Sex and Gender Curriculum to be More Inclusive of Students with Queer Genders and Intersex Students Open
We interviewed four undergraduate biology instructors who reformed their curriculum to include queer gender and intersex inclusive strategies. We found that instructors focused on changing language, often removing sexed or gendered languag…
View article: Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver
Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver Open
View article: Modulating Neutrophil Extracellular Trap Formation<i>In Vivo</i>with Locoregional Precision using Differently Charged Self-Assembled Hydrogels
Modulating Neutrophil Extracellular Trap Formation<i>In Vivo</i>with Locoregional Precision using Differently Charged Self-Assembled Hydrogels Open
Neutrophil extracellular traps (NETs) are DNA networks released by neutrophils first described as a defense response against pathogens but have since been associated with numerous inflammatory diseases. The ability to induce NETs with loco…
View article: Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver
Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver Open
Intratumoral injections have the potential for enhanced cancer treatment efficacy while reducing costs and systemic exposure. However, intratumoral drug injections can result in substantial off-target leakage and are invisible under standa…
View article: X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle-based locoregional drug delivery
X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle-based locoregional drug delivery Open
View article: Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma
Kinetically Controlled Polyelectrolyte Complex Assembly of microRNA‐Peptide Nanoparticles toward Treating Mesothelioma Open
Broad size distributions and poor long‐term colloidal stability of microRNA‐carrying nanoparticles, especially those formed by polyelectrolyte complexation, represent major hurdles in realizing their clinical translation. Herein, peptide d…
View article: X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle- based locoregional drug delivery
X-ray imageable, drug-loaded hydrogel that forms at body temperature for image-guided, needle- based locoregional drug delivery Open
Liver cancer ranks as the fifth leading cause of cancer-related death globally. Direct intratumoral injections of anti-cancer therapeutics may improve therapeutic efficacy and mitigate adverse effects compared to intravenous injections. So…
View article: The Design of a Participatory Peptide Nucleic Acid Duplex Crosslinker to Enhance the Stiffness of Self‐Assembled Peptide Gels
The Design of a Participatory Peptide Nucleic Acid Duplex Crosslinker to Enhance the Stiffness of Self‐Assembled Peptide Gels Open
Herein, peptide nucleic acids (PNAs) are employed in the design of a participatory duplex PNA‐peptide crosslinking agent. Biophysical and mechanical studies show that crosslinkers present during peptide assembly leading to hydrogelation pa…
View article: Solid organ and vascularized composite allotransplantation have distinct requirements for localized delivery of <i>enhanced costimulation blockade</i> to control rejection
Solid organ and vascularized composite allotransplantation have distinct requirements for localized delivery of <i>enhanced costimulation blockade</i> to control rejection Open
We recently demonstrated, in a mouse heart transplant model, the therapeutic effect of Enhanced Costimulation Blockade: the transient combination of CTLA4-Ig with the JAK inhibitor Tofacitinib (Tofa). In the same model, we also proved the …
View article: Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions
Hydrophilic Azide-Containing Amino Acid to Enhance the Solubility of Peptides for SPAAC Reactions Open
We report a new positively charged azidoamino acid for strain-promoted azide-alkyne cycloaddition (SPAAC) applications that overcomes possible solubility limitations of commonly used azidolysine, especially in systems with numerous ligatio…
View article: INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay
INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay Open
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the viral enzyme integrase (IN). Dolutegravir (DTG) is a l…
View article: Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies
Peptide hydrogels for affinity‐controlled release of therapeutic cargo: Current and potential strategies Open
The development of devices for the precise and controlled delivery of therapeutics has grown rapidly over the last few decades. Drug delivery materials must provide a depot with delivery profiles that satisfy pharmacodynamic and pharmacoki…
View article: Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application
Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application Open
View article: Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide
Antibacterial Gel Coatings Inspired by the Cryptic Function of a Mussel Byssal Peptide Open
Although the adhesive and cohesive nature of mussel byssal proteins have long served to inspire the design of materials embodying these properties, their characteristic amino acid compositions suggest that they might also serve to inspire …
View article: From structure to application: Progress and opportunities in peptide materials development
From structure to application: Progress and opportunities in peptide materials development Open
View article: Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes
Defining the Landscape of the Pauling-Corey Rippled Sheet: An Orphaned Motif Finding New Homes Open
When peptides are mixed with their mirror images in an equimolar ratio, two-dimensional periodic structural folds can form, in which extended peptide strands are arrayed with alternating chirality. The resultant topography class, termed th…
View article: Dopamine Self-Polymerization as a Simple and Powerful Tool to Modulate the Viscoelastic Mechanical Properties of Peptide-Based Gels
Dopamine Self-Polymerization as a Simple and Powerful Tool to Modulate the Viscoelastic Mechanical Properties of Peptide-Based Gels Open
Dopamine is a small versatile molecule used for various biotechnological and biomedical applications. This neurotransmitter, in addition to its biological role, can undergo oxidative self-polymerization to yield polydopamine, a robust univ…
View article: Serum Protein Adsorption Modulates the Toxicity of Highly Positively Charged Hydrogel Surfaces
Serum Protein Adsorption Modulates the Toxicity of Highly Positively Charged Hydrogel Surfaces Open
Hydrogels formed from peptide self-assembly are a class of materials that are being explored for their utility in tissue engineering, drug and cell delivery, two- and three-dimensional cell culture, and as adjuvants in surgical procedures.…
View article: Utilizing Frémy's Salt to Increase the Mechanical Rigidity of Supramolecular Peptide-Based Gel Networks
Utilizing Frémy's Salt to Increase the Mechanical Rigidity of Supramolecular Peptide-Based Gel Networks Open
Peptide-based supramolecular gels are an important class of biomaterials that can be used for biomedical applications ranging from drug delivery to tissue engineering. Methodology that allows one to readily modulate the mechanical properti…
View article: Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein–Protein Interactions
Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein–Protein Interactions Open
Here, we describe the use of peptide backbone N-methylation as a new strategy to transform membrane-lytic peptides (MLPs) into cytocompatible intracellular delivery vehicles. The ability of lytic peptides to engage with cell membran…
View article: Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival
Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival Open
Combination therapies that target multiple pathways involved in immune rejection of transplants hold promise for patients in need of restorative surgery. Herein, a noninteracting multiphase molecular assembly approach is developed to cryst…
View article: Structure‐based non‐nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants
Structure‐based non‐nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants Open
Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit reverse transcription and block the replication of HIV‐1. Currently, NNRTIs are usually used as part of a three‐drug combination given to patients as antiretroviral therapy. …
View article: National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library
National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library Open
An automated, high-capacity, and high-throughput procedure for the rapid isolation and identification of biologically active natural products from a prefractionated library is presented. The semipreparative HPLC method uses 1 mg of the pri…