Joëlle S. Nader
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View article: Disabling a key viral innate immunity antagonist converts measles vaccine into RIG-I-driven cancer immunotherapy
Disabling a key viral innate immunity antagonist converts measles vaccine into RIG-I-driven cancer immunotherapy Open
Oncolytic viruses can destroy tumors directly or by activating antitumor immunity, but balancing safety with potent immune stimulation remains challenging. Here, we show that deletion of the measles virus C protein, a key viral antagonist …
View article: Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment
Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment Open
Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in the tumor microenvironment (TME), such as m…
View article: Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma
Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma Open
Malignant mesothelioma (MM) still represents a devastating disease that is often detected too late, while the current effect of therapies on patient outcomes remains unsatisfactory. Invasiveness biomarkers may contribute to improving early…
View article: High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma
High Oncolytic Activity of a Double-Deleted Vaccinia Virus Copenhagen Strain against Malignant Pleural Mesothelioma Open
View article: S100A4 Is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma
S100A4 Is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma Open
Recent findings suggest that S100A4, a protein involved in communication between stromal cells and cancer cells, could be more involved than previously expected in cancer invasiveness. To investigate its cumulative value in the multistep p…
View article: The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma Open
The combination of zoledronic acid and everolimus has an antitumor effect and could increase gemcitabine efficacy.
View article: Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma
Characterization of increasing stages of invasiveness identifies stromal/cancer cell crosstalk in rat models of mesothelioma Open
Sarcomatoid mesothelioma (SM) is a devastating cancer associated with one of the poorest outcome. Therefore, representative preclinical models reproducing different tumor microenvironments (TME) observed in patients would open up new prosp…
View article: Modèles précliniques d’étude du mésothéliome : application à l’évaluation de la virothérapie anti-tumorale in vivo
Modèles précliniques d’étude du mésothéliome : application à l’évaluation de la virothérapie anti-tumorale in vivo Open
Au cours de ma these, j’ai travaille sur deux sujets complementaires. Le premier a concerne l’etude des interactions entre les cellules tumorales et leur microenvironnement, dans quatre modeles de mesotheliomes malins (MM) de rat. Les anal…
View article: Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma
Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma Open
A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration. The M5-T1 cell line, selected from a coll…
View article: Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine
Characterization of preneoplastic and neoplastic rat mesothelial cell lines: the involvement of TETs, DNMTs, and 5-hydroxymethylcytosine Open
Malignant mesothelioma (MM) is one of the worst cancers in terms of clinical outcome, urging the need to establish and characterize new preclinical tools for investigation of the tumorigenic process, improvement of early diagnosis and eval…