Joerg Buddenkotte
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View article: <scp>TDP</scp>‐43 proteinopathies and neurodegeneration: insights from <i>Caenorhabditis elegans</i> models
<span>TDP</span>‐43 proteinopathies and neurodegeneration: insights from <i>Caenorhabditis elegans</i> models Open
TDP‐linked proteinopathies, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and limbic‐predominant age‐related TDP‐43 encephalopathy (LATE), are characterised by pathogenic deposits containing transactive respo…
View article: Three cases of chronic photodermatitis successfully treated with upadacitinib
Three cases of chronic photodermatitis successfully treated with upadacitinib Open
Photodermatoses represent a varied collection of skin disorders characterized by cutaneous reactions provoked by exposure to ultraviolet radiation. The disease mechanism is based on an immune-mediated delayed hypersensitivity reaction. Cli…
View article: Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells Open
Curcumin, a plant derived natural product isolated from Curcuma longa. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of curcumin in Cutaneous T cell lymphoma (CTCL), a type of non-Hodg…
View article: Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea
Corneal Confocal Microscopy Identifies Neurodegeneration in Relation to Disease Severity and Neuropathic Symptoms in Rosacea Open
View article: Dermatitis herpetiformis successfully treated with dupilumab
Dermatitis herpetiformis successfully treated with dupilumab Open
View article: Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer
Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer Open
Interleukin 31 (IL-31) is a proinflammatory cytokine, mainly secreted by Type II helper T cells. It signals through a heterodimeric receptor complex composed of IL-31 receptor α and oncostatin-M receptor β chain. The hallmark feature of IL…
View article: Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy
Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy Open
A wide variety of inflammatory mediators, mainly cytokines and chemokines, are induced during SARS CoV‐2 infection. Among these proinflammatory mediators, chemokines tend to play a pivotal role in virus‐mediated immunopathology. The C‐C ch…
View article: Metabolomics analyses reveal the crucial role of <scp>ERK</scp> in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin
Metabolomics analyses reveal the crucial role of <span>ERK</span> in regulating metabolic pathways associated with the proliferation of human cutaneous T‐cell lymphoma cells treated with Glabridin Open
Cutaneous T‐cell lymphomas (CTC) are a heterogeneous group of T‐cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in orchestrating the unc…
View article: Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans
Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans Open
View article: Retrospective evaluation of a <scp>TEN</scp>/<scp>SJS</scp> series managed with a new treatment protocol
Retrospective evaluation of a <span>TEN</span>/<span>SJS</span> series managed with a new treatment protocol Open
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening diseases without standardized treatment. The mortality rate ranges from 20% to 50%, and can reach up to 90%, based on the severity index SCORTEN…
View article: Recalcitrant pityriasis rubra pilaris in a Middle Eastern patient and arguments for early anti‐IL‐23 targeting
Recalcitrant pityriasis rubra pilaris in a Middle Eastern patient and arguments for early anti‐IL‐23 targeting Open
Pityriasis rubra pilaris (PRP) is a rare, chronic cutaneous inflammatory disorder of keratinization affecting adults, children and patients with HIV. The pathogenesis of PRP is not fully understood with clinical presentations, and severity…
View article: Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway
Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway Open
View article: Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway
Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway Open
Background: The benzophenanthridine Sanguinarine (Sng) is one of the most abundant root alkaloids with a long history of investigation and pharmaceutical applications. The cytotoxicity of Sng against various tumor cells is well-established…
View article: Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation
Azithromycin downregulates ICOS (CD278) and OX40 (CD134) expression and mTOR activity of TCR-activated T cells to inhibit proliferation Open
View article: Sanguinarine triggers apoptosis in cutaneous squamous cell carcinoma cells through ROS-dependent JNK-kinase signaling
Sanguinarine triggers apoptosis in cutaneous squamous cell carcinoma cells through ROS-dependent JNK-kinase signaling Open
Cutaneous Squamous Cell Carcinoma (cSCC), the second most common non-melanoma skin cancer, originates from the malignant transformation of atypical epidermal keratinocytes. In recent decades, contemporary research has widened our comprehen…
View article: Itch in elderly patients: Origin, diagnostics, management
Itch in elderly patients: Origin, diagnostics, management Open
View article: Epigenetic control of inflammation in Atopic Dermatitis
Epigenetic control of inflammation in Atopic Dermatitis Open
View article: Efficacy of Dupilumab in severe Atopic Dermatitis (AD) using the AD Control Tool (ADCT) Score in the population of Qatar.
Efficacy of Dupilumab in severe Atopic Dermatitis (AD) using the AD Control Tool (ADCT) Score in the population of Qatar. Open
Atopic Dermatitis (AD) is a high-burden disease that affects approximately 2-5% of adults. AD patients experience intense pruritus and often report sleep and mental health disturbances accompanied by a diminished quality of life. The patie…
View article: Epidemiology of Geriatric-Dermatology virtual clinic: Teledermatology-Based care for elderly patients with skin diseases in Qatar.
Epidemiology of Geriatric-Dermatology virtual clinic: Teledermatology-Based care for elderly patients with skin diseases in Qatar. Open
Background: The 'GeriDerm' (geriatric dermatology) clinic, is a new dermatology-based service at Hamad Medical Corporation (HMC), accommodating the needs of our elderly population living in the State of Qatar. Due to the global demo…
View article: Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes
Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes Open
View article: Pristimerin mediated anticancer effects and sensitization of human skin cancer cells through modulation of MAPK signaling pathways
Pristimerin mediated anticancer effects and sensitization of human skin cancer cells through modulation of MAPK signaling pathways Open
Squamous cell carcinoma is a frequent skin cancer still demanding to understand the underlying mechanisms for better clinical outcomes. Pristimerin, a natural quinonemethide triterpenoid, has shown promising therapeutic outcome due to its …
View article: The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities Open
View article: Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance
Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance Open
View article: Table of Contents
Table of Contents Open
View article: The PLAUR signaling promotes chronic pruritus
The PLAUR signaling promotes chronic pruritus Open
Chronic itch is a complex sensation of the skin frequently associated with skin diseases, such as atopic dermatitis (AD) and psoriasis. Although Serpin E1 is implicated in chronic itch, its receptor and signaling pathways involved in itch …
View article: Recalcitrant Erythrodermic Ichthyosis with Atopic Dermatitis Successfully Treated with Dupilumab in Combination with Guselkumab
Recalcitrant Erythrodermic Ichthyosis with Atopic Dermatitis Successfully Treated with Dupilumab in Combination with Guselkumab Open
Background Autosomal recessive congenital ichthyosis refers to a group of rare inherited disorders of keratinization and defective epidermal barrier resulting in varying clinical presentations and severities ranging from harlequin ichthyos…
View article: Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways Open
Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive…
View article: Treatment and molecular profiling of acrodermatitis continua of Hallopeau during pregnancy using targeted therapy
Treatment and molecular profiling of acrodermatitis continua of Hallopeau during pregnancy using targeted therapy Open
View article: Neurokinin 1 Receptor Antagonists for Pruritus
Neurokinin 1 Receptor Antagonists for Pruritus Open
Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant dist…
View article: Interleukin‐31: The “itchy” cytokine in inflammation and therapy
Interleukin‐31: The “itchy” cytokine in inflammation and therapy Open
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD, IL‐31 has been identified as one of the main “driver…