Joey Ward
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View article: Exploring risk and protective factors which distinguish suicidal and self-harm behaviours from suicidal and self-harm ideation in young people: A systematic review
Exploring risk and protective factors which distinguish suicidal and self-harm behaviours from suicidal and self-harm ideation in young people: A systematic review Open
Background Self-harm and suicidal thoughts and behaviours among young people are significant global public health concerns. Although most young people with thoughts of self-harm or suicide do not act on their thoughts, it is important to i…
View article: <i> <b>PCSK9</b> </i> <b>genetic variants, carotid atherosclerosis and vascular remodelling</b>
<i> <b>PCSK9</b> </i> <b>genetic variants, carotid atherosclerosis and vascular remodelling</b> Open
Background Circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein chole…
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N = 252,340) Open
It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health on the risk of Alzheimer’s disease (AD). We tested for associations between measures of premorbid cognitive health, apolipoprotei…
View article: Genetic predisposition to adiposity, and type 2 diabetes: the role of lifestyle and phenotypic adiposity
Genetic predisposition to adiposity, and type 2 diabetes: the role of lifestyle and phenotypic adiposity Open
Aims Genetic predisposition to adiposity is associated with type 2 diabetes (T2D), even in the absence of phenotypic adiposity (obesity and central obesity). We aimed to quantify the overall contribution of obesity and modifiable lifestyle…
View article: Testing for associations and interactions between APOE e4 genotype and lifestyle, with brain structural imaging phenotypes in UK Biobank
Testing for associations and interactions between APOE e4 genotype and lifestyle, with brain structural imaging phenotypes in UK Biobank Open
Apolipoprotein E gene (APOE) e4 allele is the strongest common genetic risk factor for dementia. High genetic risk of dementia could be offset by healthy lifestyle. However, the effects of daily lifestyle and genetic risk on brain structur…
View article: <i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodelling
<i>PCSK9</i>genetic variants, carotid atherosclerosis and vascular remodelling Open
Background and aims Circulating PCSK9 is a crucial regulator of cholesterol metabolism. Loss-of-function variants in PCSK9 are associated with lower levels of circulating low-density lipoprotein cholesterol (LDL-C) and reduced cardiovascul…
View article: Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility
Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility Open
Background Associations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with incident CAD, com…
View article: Association of <scp> <i>GLP1R</i> </scp> locus with mental ill‐health endophenotypes and cardiometabolic traits: A trans‐ancestry study in <scp>UK</scp> Biobank
Association of <span> <i>GLP1R</i> </span> locus with mental ill‐health endophenotypes and cardiometabolic traits: A trans‐ancestry study in <span>UK</span> Biobank Open
Aims Glucagon‐like peptide 1 receptor agonists (GLP1RA), used to treat type 2 diabetes and obesity, have been associated with off‐target behavioural effects. We systematically assessed genetic variation in the GLP1R locus for impact on men…
View article: Associations and interactions between <i>APOE</i> e4 genotype and lifestyle with brain structural phenotypes
Associations and interactions between <i>APOE</i> e4 genotype and lifestyle with brain structural phenotypes Open
Apolipoprotein E gene (APOE) e4 allele is known as the strongest common genetic risk factor for Alzheimer’s disease. Various lifestyle factors are reported to have multiple associations with brain health, including smoking, alcohol intake,…
View article: Lifetime depression, sleep disruption and brain structure in the UK Biobank cohort
Lifetime depression, sleep disruption and brain structure in the UK Biobank cohort Open
Whether depression and poor sleep interact or have statistically independent associations with brain structure and its change over time is not known. Within a subset of UK Biobank participants with neuroimaging and subjective and/or object…
View article: Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340)
Associations and interactions between premorbid cognitive health, apolipoprotein e4 genotype, and incident Alzheimer’s disease in UK Biobank (N=252,340) Open
Background: It is unclear to what extent genetic risk offsets the protective effects of better premorbid cognitive health, on risk of Alzheimer’s disease (AD). To address this, we tested for associations between measures of premorbid cogni…
View article: Childhood maltreatment, adulthood obesity and incident type 2 diabetes: a retrospective cohort study using UK Biobank
Childhood maltreatment, adulthood obesity and incident type 2 diabetes: a retrospective cohort study using UK Biobank Open
Background This study aims to explore the association of childhood maltreatment with obesity and type 2 diabetes (T2D) in adulthood, and whether obesity is a mediator of the latter. Methods In a retrospective cohort study using UK Biobank …
View article: Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study
Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study Open
PCSK9-inhibitors (PCSK9i) are new drugs recently approved to lower LDL-cholesterol levels. However, due to the lack of long-term clinical data, the potential adverse effects of long-term use are still unknown. The PCSK9 genetic locus has b…
View article: How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank
How do lifestyle factors modify the association between genetic predisposition and obesity-related phenotypes? A 4-way decomposition analysis using UK Biobank Open
View article: <i>BMAL1</i> Genetic Variation in Metabolic and Mental Health
<i>BMAL1</i> Genetic Variation in Metabolic and Mental Health Open
Aims Epidemiological studies have previously shown a link between cardiometabolic disease and severe mental illness. The extent and mechanisms behind this link are poorly understood currently but links to impairments in the stress response…
View article: A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (<i>n</i> = 50 376)
A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (<i>n</i> = 50 376) Open
Traumatic brain injury (TBI) is a risk factor for neurodegenerative disease. We currently have no means to identify patients most at risk of neurodegenerative disease following injury and, resultantly, no means to target risk mitigation in…
View article: Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data
Head motion in the UK Biobank imaging subsample: longitudinal stability, associations with psychological and physical health, and risk of incomplete data Open
Participant motion in brain magnetic resonance imaging is associated with processing problems including potentially non-useable/incomplete data. This has implications for representativeness in research. Few large studies have investigated …
View article: Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts
Consistent effects of the genetics of happiness across the lifespan and ancestries in multiple cohorts Open
View article: Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank
Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank Open
Genetic variation in the DCC locus had distinct effects on BMI, smoking and mood traits, and therefore is unlikely to contribute to shared mechanisms underpinning mental and cardiometabolic traits.
View article: Testing for associations between <scp>HbA1c</scp> levels, polygenic risk and brain health in <scp>UK</scp> Biobank ( <i>N</i> = 39 283)
Testing for associations between <span>HbA1c</span> levels, polygenic risk and brain health in <span>UK</span> Biobank ( <i>N</i> = 39 283) Open
Aim To investigate whether continuous HbA1c levels and HbA1c‐polygenic risk scores (HbA1c‐PRS) are significantly associated with worse brain health independent of type 2 diabetes (T2D) diagnosis (vs. not), by examining brain structure and …
View article: Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism
Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism Open
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are associated with an increased risk of cardiovascular diseases, including venous thromboembolism (VTE). The reasons for this are complex and include obesity,…
View article: Normative values of the brain health index in UK biobank
Normative values of the brain health index in UK biobank Open
View article: Head motion in the UK Biobank imaging sub-sample: longitudinal stability, associations with psychological and physical health, and risk of non-useable data
Head motion in the UK Biobank imaging sub-sample: longitudinal stability, associations with psychological and physical health, and risk of non-useable data Open
Background: Participant motion in magnetic resonance imaging (MRI) is associated with processing problems including potentially non-useable data. This has implications for representativeness in research. Few large studies have investigated…
View article: Subjective and objective sleep and circadian parameters as predictors of depression-related outcomes: A machine learning approach in UK Biobank
Subjective and objective sleep and circadian parameters as predictors of depression-related outcomes: A machine learning approach in UK Biobank Open
View article: Cognitive Function in People With Familial Risk of Depression
Cognitive Function in People With Familial Risk of Depression Open
Importance Cognitive impairment in depression is poorly understood. Family history of depression is a potentially useful risk marker for cognitive impairment, facilitating early identification and targeted intervention in those at highest …
View article: Genetic architecture of the HLA/MHC locus in cardiometabolic disease, severe mental illness, and related traits.
Genetic architecture of the HLA/MHC locus in cardiometabolic disease, severe mental illness, and related traits. Open
Background The Human Leucocyte Antigen/Major Histocompatibility Complex (HLA/MHC) locus is highly complex, with very many genetic variants, extensive linkage disequilibrium blocks, population-specific linkage disequilibrium patterns and ma…
View article: Testing for associations between HbA1c levels, polygenic risk, and brain health in UK Biobank (N=39,283)
Testing for associations between HbA1c levels, polygenic risk, and brain health in UK Biobank (N=39,283) Open
Objective: Type-2 diabetes (T2D) has been associated with poorer brain health, and glycated haemoglobin (HbA1c) levels is a diagnostic test for diabetes. The aim of this study was to investigate whether continuous HbA1c levels, and HbA1c p…
View article: Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization
Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization Open
Prescription of PCSK9-inhibitors has increased in recent years but not much is known about its off-target effects. PCSK9 -expression is evident in non-hepatic tissues, notably the brain, and genetic variation in the PCSK9 locus has recentl…
View article: Genetic risk for severe mental illness does not influence adipose tissue functions.
Genetic risk for severe mental illness does not influence adipose tissue functions. Open
Background: Psychiatric disorders are associated with an increased risk of metabolic diseases, including obesity. The aim of this study was to determine whether genetic variants associated with severe mental illness (individually or combin…
View article: Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank
Genetic architecture of DCC and influence on psychological, psychiatric and cardiometabolic traits in multiple ancestry groups in UK Biobank Open
People with severe mental illness have a higher risk of cardiometabolic disease than the general population. Traditionally attributed to sociodemographic and behavioural factors and medication effects, recent genetic studies have provided …