Explanipedia

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosis Open

Taylor Adams, Jonas C. Schupp, Agshin Balayev, Johad Khoury, A. Justet , et al. · 2025

Acute and repetitive lung epithelial injury can lead to irreversible and even progressive pulmonary fibrosis; Idiopathic pulmonary fibrosis (IPF) is a fatal disease and quintessential example of this phenomenon. The composition of epitheli…

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1 Open

Riham Smoom, Catherine Lee May, Dan Lichtental, Kamil Bar-Ness, Roberto Rangel , et al. · 2025

RTEL1 is an essential DNA helicase that plays multiple roles in genome stability and telomere length regulation. The ultra-long telomeres of the house mouse hinder its utility as a model for telomere-related diseases. We have previously ge…

Ticagrelor Versus Prasugrel in Acute Coronary Syndrome: Real-World Treatment and Safety Open

Fadel Bahouth, Boris Chutko, Haitham Sholy, Sabreen Hassanain, Gh. Zaid , et al. · 2025

Introduction: A direct head-to-head comparison between potent P2Y12 inhibitors: prasugrel versus ticagrelor is still lacking. Purpose: In this single-center study, we sought to address the efficacy and safety of these two third-generation …

Vascular endothelial growth factor-D improves lung vascular integrity during acute lung injury Open

Yifan Yuan, Lokesh Sharma, Wenwen Tang, Young Won Yoon, Susan E. Kirk , et al. · 2024

Disorders in pulmonary vascular integrity are a prominent feature in many lung diseases. Paracrine signaling is highly enriched in the lung and plays a crucial role in regulating vascular homeostasis. However, the specific local cell-cell …

The role of GPR87 in Pulmonary Fibrosis Open

Johad Khoury, Farida Ahangari, Taylor Adams, A. Justet, Edward P. Manning , et al. · 2024

Rationale G- protein coupled receptor 87 (GPR87), an alternative lysophosphatidic acid (LPA) receptor previously implicated in cancer, is highly expressed in basal and aberrant basaloid cells in idiopathic pulmonary fibrosis (IPF). We soug…

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury Open

Z.M. Harris, Asawari Korde, Johad Khoury, Edward P. Manning, Gail Stanley , et al. · 2024

While delivery of supplemental oxygen is a life-saving therapy, exposure to high levels of oxygen, called hyperoxia, is associated with increased mortality in the intensive care unit (ICU). Hyperoxia leads to oxidant-mediated acute lung in…

Association between COVID-19 Infection and Pulmonary Fibrosis: A Nested Case-Control Study Open

Ronza Najjar-Debbiny, Ofra Barnett‐Griness, Johad Khoury, Naomi Gronich, Regina Weber , et al. · 2023

Effectiveness of Molnupiravir in High-Risk Patients: A Propensity Score Matched Analysis Open

Ronza Najjar‐Debbiny, Naomi Gronich, Regina Weber, Johad Khoury, Maisam Amar , et al. · 2022

Background Molnupiravir was granted emergency use authorization for the treatment of mild to moderate coronavirus disease 2019 (COVID-19). In this study, we used population-based real-world data to evaluate the effectiveness of molnupiravi…

Impact of Adherence to Continuous Positive Airway Pressure on Outcomes in Obstructive Sleep Apnea Chronic Obstructive Pulmonary Disease Overlap Syndrome Open

Johad Khoury, Fahed Hakim · 2022

Effectiveness of Paxlovid in Reducing Severe Coronavirus Disease 2019 and Mortality in High-Risk Patients Open

Ronza Najjar‐Debbiny, Naomi Gronich, Regina Weber, Johad Khoury, Maisam Amar , et al. · 2022

Background Paxlovid was granted an Emergency Use Authorization for the treatment of mild to moderate coronavirus disease 2019 (COVID-19), based on the interim analysis of the Evaluation of Protease Inhibition for COVID-19 in High-Risk Pati…

Cognitive dysfunction following COVID-19 infection Open

Rafi Hadad, Johad Khoury, Chen Stanger, Tali Fisher, Sonia Schneer , et al. · 2022

The coronavirus (COVID-19) pandemic is still evolving, causing hundreds of millions of infections around the world. The long-term sequelae of COVID-19 and neurologic syndromes post COVID remain poorly understood. The present study aims to …

Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro Open

Dinesh Babu Uthaya Kumar, Efthymios Motakis, Marina Yurieva, Vivek Kohar, Jan Martínek , et al. · 2022

Although epithelial-mesenchymal transition (EMT) is a common feature of fibrotic lung disease, its role in fibrogenesis is controversial. Recently, aberrant basaloid cells were identified in fibrotic lung tissue as a novel epithelial cell …

The prognostic value of heart rate at discharge in acute decompensation of heart failure with reduced ejection fraction Open

Fadel Bahouth, Adi Elias, Itai Ghersin, Emad E. Khoury, Omer Bar , et al. · 2021

Aims The effect of elevated heart rate (HR) on morbidity and mortality is evident in chronic stable heart failure; data in this regard in acute decompensated heart failure (ADHF) setting are scarce. In this single‐centre study, we sought t…

COVID-19 vaccine – Long term immune decline and breakthrough infections Open

Johad Khoury, Ronza Najjar‐Debbiny, Ayman Hanna, Adel Jabbour, Yara Abu Ahmad , et al. · 2021

Direct antiviral agents for chronic hepatitis C virus infection improve health-related quality of life significantly in the long term Open

Mahmoud Atamla, Johad Khoury, Ihab Dabbah, Rimma Kramsky, Afif Yaacob , et al. · 2021

Treatment with DAAs improves HRQL significantly in the long term.

SOFA score and short-term mortality in acute decompensated heart failure Open

Adi Elias, Reham Agbarieh, Walid Saliba, Johad Khoury, Fadel Bahouth , et al. · 2020

ERS International Congress, Madrid, 2019: highlights from the Pulmonary Vascular Diseases Assembly Open

Sheila Ramjug, Jason Weatherald, Sandeep Sahay, Johad Khoury, Vasile Foris , et al. · 2020

The 2019 European Respiratory Society (ERS) International Congress, held in Madrid, Spain, had exciting sessions regarding the field of pulmonary vascular disease. The symposia related to the new ERS/European Society of Cardiology (ESC) Gu…

Natriuretic Peptides Attenuate the Ability of the Lungs to Clear Edema Open

Zaher S. Azzam, Y. Knany, Safa Kinaneh, Emad E. Khoury, Johad Khoury , et al. · 2020

Analyzing Medical Research Results Based on Synthetic Data and Their Relation to Real Data Results: Systematic Comparison From Five Observational Studies Open

Anat Reiner‐Benaim, Ronit Almog, Yuri Gorelik, Irit Hochberg, Laila Nassar , et al. · 2019

Background Privacy restrictions limit access to protected patient-derived health information for research purposes. Consequently, data anonymization is required to allow researchers data access for initial analysis before granting institut…

A Validation Study for Medical Research Based on Synthetic Hospital Data (Preprint) Open

Anat Reiner‐Benaim, Ronit Almog, Yuri Gorelik, Irit Hochberg, Laila Nassar , et al. · 2019

BACKGROUND Privacy restrictions limit access to protected patient-derived health information for research purposes. Consequently, data anonymization is required to allow researchers data access for initial analysis before granting Institu…

Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome Open

Halim Awadie, Johad Khoury, Yaniv Zohar, Afif Yaccob, Ella Veitsman , et al. · 2019

Idiopathic hypereosinophilic syndrome (HES) is a rare, heterogeneous disorder characterized by a strikingly high eosinophil count (>1,500 cells/μL), over a long period of time (>6 months), with end organ damage. We present a 60-year-old pa…

Blood urea nitrogen variation upon admission and at discharge in patients with heart failure Open

Johad Khoury, Fadel Bahouth, Yoav Stabholz, Adi Elias, Tanya Mashiach , et al. · 2019

Aims Heart failure (HF) is one of the leading causes for hospitalization and mortality. After first admission with acute decompensated HF, some patients are in high risk for short‐term and long‐term mortality. These patients should be iden…

Unexpected bleeding after Exenatide treatment: a causative relationship or a coincidence? Open

Johad Khoury, Elias Andrawus, Boaz Bishop, Zaher S. Azzam · 2018

Objectives. Diabetes mellitus is an endemic disease of the current era. It is important to treat it properly. All antidiabetic medications have side effects and various safety profiles. Case report. Fifty-two years old patient with type II…

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