Johan De Houwer
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View article: Synthesis of Functionalized Pyrazin-2(1<i>H</i>)-ones via Tele-Nucleophilic Substitution of Hydrogen Involving Grignard Reactants and Electrophiles
Synthesis of Functionalized Pyrazin-2(1<i>H</i>)-ones via Tele-Nucleophilic Substitution of Hydrogen Involving Grignard Reactants and Electrophiles Open
The reaction of 6-chloro-1-methylpyrazin-2(1 H)-one with Grignard reactants followed by quenching with different electrophiles gave access to a variety of 3,6-difunctionalized 1-methylpyrazin-2(1 H)-ones. This regioselective three-componen…
View article: CCDC 1897429: Experimental Crystal Structure Determination
CCDC 1897429: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen
Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen Open
The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoic…
View article: Mechanism of the Cu<sup>II</sup>-catalyzed benzylic oxygenation of (aryl)(heteroaryl)methanes with oxygen
Mechanism of the Cu<sup>II</sup>-catalyzed benzylic oxygenation of (aryl)(heteroaryl)methanes with oxygen Open
A mechanistic study of the copper-catalyzed oxidation of the methylene group of aryl(di)azinylmethanes was performed.