Johan E. Gustafsson
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View article: Future generations and the evidential veil of ignorance
Future generations and the evidential veil of ignorance Open
Ideal Contractualism views principles of justice as corresponding to what rational, mutually disinterested persons would collectively choose behind a veil of ignorance. It is well-known that Ideal Contractualism faces profound challenges i…
View article: Pre-existing cytotoxic capacity of CD8+ and CD4+ T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy
Pre-existing cytotoxic capacity of CD8+ and CD4+ T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy Open
Immune checkpoint blockade (ICB) therapy has shown promising activity in Richter Transformation (RT), yet the tumor microenvironmental (TME) determinants of response and resistance to this therapy remain incompletely defined. Our previous …
View article: Stochastic Dominance for Incomplete Preferences
Stochastic Dominance for Incomplete Preferences Open
According to Stochastic Dominance, it is rationally obligatory to prefer one gamble to another if it gives you the same chances of getting final outcomes you prefer. According to Statewise Maximality, it is rationally permissible not to di…
View article: The Disjunctive Repugnant Conclusion
The Disjunctive Repugnant Conclusion Open
Critical-Level Utilitarianism entails one of the Repugnant Conclusion and the Sadistic Conclusion, depending on the critical level. Indeterminate Critical-Level Utilitarianism is a version of Critical-Level Utilitarianism where it is indet…
View article: Numbat-multiome: inferring copy number variations by combining RNA and chromatin accessibility information from single-cell data
Numbat-multiome: inferring copy number variations by combining RNA and chromatin accessibility information from single-cell data Open
Aberrant alterations in genome copy number, chromatin accessibility, and transcriptional programs all play pivotal roles in cancer. The Numbat algorithm has been widely adopted to perform copy number variation (CNV) inference from single-c…
View article: A behavioural money-pump argument for completeness
A behavioural money-pump argument for completeness Open
Completeness says that, for every pair of prospects, at least one of the prospects is at least as preferred as the other. I present a new money-pump argument that Completeness is a requirement of rationality. In comparison with earlier mon…
View article: A Universal Money Pump for the Myopic, Naive, and Minimally Sophisticated
A Universal Money Pump for the Myopic, Naive, and Minimally Sophisticated Open
The money-pump argument aims to show that cyclic preferences are irrational. The argument can be based on a number of different exploitation schemes that vary in what needs to be assumed about the agent. The Standard Money Pump works for m…
View article: The Foresight Response to Money Pumps Refuted in Words of One Syllable
The Foresight Response to Money Pumps Refuted in Words of One Syllable Open
I show, in words of one block of sound, that, while those whose likes form a loop could stop some wealth pumps if they now did what they would like most based on what they thought they would do next, there are wealth pumps they could not s…
View article: Workflows Community Summit 2024: Future Trends and Challenges in Scientific Workflows
Workflows Community Summit 2024: Future Trends and Challenges in Scientific Workflows Open
The 2024 Workflows Community Summit report presents the outcomes of a three-day international gathering that brought together 111 experts from 18 countries to discuss future trends and challenges in scientific workflows. The summit focused…
View article: Workflows Community Summit 2024: Future Trends and Challenges in Scientific Workflows
Workflows Community Summit 2024: Future Trends and Challenges in Scientific Workflows Open
The 2024 Workflows Community Summit report presents the outcomes of a three-day international gathering that brought together 111 experts from 18 countries to discuss future trends and challenges in scientific workflows. The summit focused…
View article: Binary act consequentialism
Binary act consequentialism Open
According to Act Consequentialism, an act is right if and only if its outcome is not worse than the outcome of any alternative to that act. This view, however, leads to deontic paradoxes if the alternatives to an act are all other acts tha…
View article: The Need for Merely Possible People
The Need for Merely Possible People Open
W. V. Quine wished to restrict the interests that matter to those of actual people. Actual-Population Utilitarianism is a version of utilitarianism whereby, following Quine, only the interests of actual people matter. It is well known that…
View article: WorkflowHub
WorkflowHub Open
View article: EOSC-Life Workflow Collaboratory for the Life Sciences
EOSC-Life Workflow Collaboratory for the Life Sciences Open
Workflows have become a major tool for the processing of Research Data, for example, data collection and data cleaning pipelines, data analytics, and data update feeds populating public archives. The EOSC-Life Research Infrastructure Clust…
View article: Dennett’s prime‐mammal objection to the consequence argument
Dennett’s prime‐mammal objection to the consequence argument Open
The Consequence Argument is the classic argument for the incompatibility of determinism and our ability to do otherwise. Daniel C. Dennett objects that the Consequence Argument suffers from the same error as a clearly unconvincing argument…
View article: Workflows Community Summit 2022: A Roadmap Revolution
Workflows Community Summit 2022: A Roadmap Revolution Open
Scientific workflows have become integral tools in broad scientific computing use cases. Science discovery is increasingly dependent on workflows to orchestrate large and complex scientific experiments that range from execution of a cloud-…
View article: Workflows Community Summit 2022: A Roadmap Revolution
Workflows Community Summit 2022: A Roadmap Revolution Open
Scientific workflows have become integral tools in broad scientific computing use cases. Science discovery is increasingly dependent on workflows to orchestrate large and complex scientific experiments that range from the execution of a cl…
View article: The possibility of undistinguishedness
The possibility of undistinguishedness Open
It is natural to assume that every value bearer must be good, bad, or neutral. This paper argues that this assumption is false if value incomparability is possible. More precisely, if value incommensurability is possible, then there is a f…
View article: Do Lefty and Righty Matter More Than Lefty Alone?
Do Lefty and Righty Matter More Than Lefty Alone? Open
Derek Parfit argues that fission is prudentially better for you than ordinary death. But is having more fission products with good lives prudentially better for you than having just one? In this paper, we argue that it is. We argue that, i…
View article: Money-Pump Arguments
Money-Pump Arguments Open
Suppose that you prefer A to B, B to C, and C to A. Your preferences violate Expected Utility Theory by being cyclic. Money-pump arguments offer a way to show that such violations are irrational. Suppose that you start with A. Then you sho…
View article: Bentham's Mugging
Bentham's Mugging Open
A dialogue, in three parts, on utilitarian vulnerability to exploitation.
View article: Second Thoughts About My Favourite Theory
Second Thoughts About My Favourite Theory Open
A straightforward way to handle moral uncertainty is simply to follow the moral theory in which you have most credence. This approach is known as My Favourite Theory. In this paper, I argue that, in some cases, My Favourite Theory prescrib…
View article: Decisions under Ignorance and the Individuation of States of Nature
Decisions under Ignorance and the Individuation of States of Nature Open
How do you make decisions under ignorance? That is, how do you decide when you lack subjective probabilities for some of your options’ possible outcomes? One answer is that you follow the Laplace Rule: you assign an equal probability to ea…
View article: Ex-Ante Prioritarianism Violates Sequential Ex-Ante Pareto
Ex-Ante Prioritarianism Violates Sequential Ex-Ante Pareto Open
Prioritarianism is a variant of utilitarianism. It differs from utilitarianism in that benefiting individuals matters more the worse off these individuals are. On this view, there are two standard ways of handling risky prospects: Ex-Post …
View article: Utilitarianism without Moral Aggregation
Utilitarianism without Moral Aggregation Open
Is an outcome where many people are saved and one person dies better than an outcome where the one is saved and the many die? According to the standard utilitarian justification, the former is better because it has a greater sum total of w…
View article: What Should We Agree on about the Repugnant Conclusion?
What Should We Agree on about the Repugnant Conclusion? Open
The Repugnant Conclusion is an implication of some approaches to population ethics. It states, in Derek Parfit's original formulation, For any possible population of at least ten billion people, all with a very high quality of life, there …
View article: Is Psychology What Matters in Survival?
Is Psychology What Matters in Survival? Open
According to the Psychological-Continuity Account of What Matters, you are justified in having special concern for the well-being of a person at a future time if and only if that person will be psychologically continuous with you as you ar…
View article: Permissibility Is the Only Feasible Deontic Primitive
Permissibility Is the Only Feasible Deontic Primitive Open
Moral obligation and permissibility are usually thought to be interdefinable. Following the pattern of the duality definitions of necessity and possibility, we have that something's being permissible could be defined as its not being oblig…
View article: The Levelling-Down Objection and the additive measure of the badness of inequality
The Levelling-Down Objection and the additive measure of the badness of inequality Open
The Levelling-Down Objection is a standard objection to monistic egalitarian theories where equality is the only thing that has intrinsic value. Most egalitarians, however, are value pluralists; they hold that, in addition to equality bein…
View article: Sources of Variation in Cell-Type RNA-Seq Profiles
Sources of Variation in Cell-Type RNA-Seq Profiles Open
This is the code and processed data associated with the paper "Sources of Variation in Cell-Type RNA-Seq Profiles" (to be updated once published), all details are explained in the paper. If you use the data, please cite that paper instead …