Johan Högberg
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View article: Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence sugge…
View article: Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Overexpression of HBx protein increases pAkt level in Huh7 cells.
View article: Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Atorvastatin decreases proliferation in hepatocytes.
View article: Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Supplemental Legends
View article: Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplemental Legends from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Supplemental Legends
View article: Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Data from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer-related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol-lowering drugs, and recent epidemiologic evidence sugge…
View article: Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 1 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Overexpression of HBx protein increases pAkt level in Huh7 cells.
View article: Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors
Supplementary Data Figure 2 from Atorvastatin Decreases HBx-Induced Phospho-Akt in Hepatocytes via P2X Receptors Open
Atorvastatin decreases proliferation in hepatocytes.
View article: Approaches for the setting of occupational exposure limits (OELs) for carcinogens
Approaches for the setting of occupational exposure limits (OELs) for carcinogens Open
This article addresses issues of importance for occupational exposure limits (OELs) and chemical carcinogens with a focus on non-threshold carcinogens. It comprises scientific as well as regulatory issues. It is an overview, not a comprehe…
View article: ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles
ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles Open
Crystalline silica particles (CSi) are an established human carcinogen, but it is not clear how these particles cause necessary mutations. A well-established scenario includes inflammation caused by retained particles in the bronchioles, a…
View article: Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs)
Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs) Open
BACKGROUND: Cancer risk assessment of complex exposures, such as exposure to mixtures of polycyclic aromatic hydrocarbons (PAHs), is challenging due to the diverse biological activities of these compounds. With the help of text mining (TM)…
View article: Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation
Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation Open
Autotaxin (ATX) and its product lysophosphatidic acid (LPA) have been implicated in lung fibrosis and cancer. We have studied their roles in DNA damage induced by carcinogenic crystalline silica particles (CSi). In an earlier study on bron…
View article: Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells
Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells Open
Background Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be …
View article: PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells
PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells Open
Characterization of Akt regulation may lead to a better understanding of tumor development and to novel strategies for treatment.
View article: LION LBD: a literature-based discovery system for cancer biology
LION LBD: a literature-based discovery system for cancer biology Open
Motivation The overwhelming size and rapid growth of the biomedical literature make it impossible for scientists to read all studies related to their work, potentially leading to missed connections and wasted time and resources. Literature…
View article: ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage?
ATM-activated autotaxin (ATX) propagates inflammation and DNA damage in lung epithelial cells: a new mode of action for silica-induced DNA damage? Open
Silica exposure is a common risk factor for lung cancer. It has been claimed that key elements in cancer development are activation of inflammatory cells that indirectly induce DNA damage and proliferative stimuli in respiratory epithelial…
View article: Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer
Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer Open
Motivation To understand the molecular mechanisms involved in cancer development, significant efforts are being invested in cancer research. This has resulted in millions of scientific articles. An efficient and thorough review of the exis…
View article: MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 IS ACTIVATED IN RESPONSE TO INHIBITED Akt SIGNALING.
MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 IS ACTIVATED IN RESPONSE TO INHIBITED Akt SIGNALING. Open
The image used to represent Mdm2 from DCA, PD98059, and U0126-treated HepG2 cells in Fig. 3B was mistakenly used to represent Mdm2 from anisomycin-treated cells in Fig. 3C.This error has now been corrected.This correction does not affect t…
View article: Exposure to polychlorinated biphenyls and prostate cancer: population-based prospective cohort and experimental studies
Exposure to polychlorinated biphenyls and prostate cancer: population-based prospective cohort and experimental studies Open
Polychlorinated biphenyls (PCBs) are highly persistent environmental pollutants and are undesirable components of our daily food. PCBs are classified as human carcinogens, but the evidence for prostate cancer is limited and available data …
View article: Gender differences in cancer susceptibility: role of oxidative stress
Gender differences in cancer susceptibility: role of oxidative stress Open
Cancer is a leading cause of death worldwide and environmental factors, including chemicals, have been suggested as major etiological incitements. Cancer statistics indicates that men get more cancer than women. However, differences in the…