Johan Bengtsson‐Palme
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View article: Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation
Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation Open
Milk oligosaccharides are crucial for neonatal development and health in mammals. Yet most milk research focuses on humans, or on domesticated mammals that are poor in milk oligosaccharide complexity. Here, we perform an exhaustive mass sp…
View article: Correction: Low coverage of species constrains the use of DNA barcoding to assess mosquito biodiversity
Correction: Low coverage of species constrains the use of DNA barcoding to assess mosquito biodiversity Open
View article: Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol
Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol Open
Antibiotic resistance poses a global public health threat. Cefiderocol, a recently introduced siderophore cephalosporin, employs a “Trojan Horse” mechanism by exploiting bacterial iron uptake systems for cell entry. Yet, resistant clinical…
View article: Gender differences in global antimicrobial resistance
Gender differences in global antimicrobial resistance Open
Antimicrobial resistance is one of the leading causes of mortality globally. However, little is known about the distribution of antibiotic resistance genes (ARGs) in human gut metagenomes, collectively referred to as the resistome, across …
View article: Community-promoted antibiotic resistance genes show increased dissemination among pathogens
Community-promoted antibiotic resistance genes show increased dissemination among pathogens Open
Antibiotic resistance is increasing among bacterial pathogens, posing one of the most severe threats to future public health. A major contributor to the increasing resistance is the dissemination of mobile antibiotic resistance genes (ARGs…
View article: Fish are poor sentinels for surveillance of riverine antimicrobial resistance
Fish are poor sentinels for surveillance of riverine antimicrobial resistance Open
View article: Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update
Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update Open
Carbapenemase‐producing Enterobacterales (CPE) have been reported in the food chain in 14 out of 30 EU/EFTA countries. Commonly reported genes are blaVIM‐1, blaOXA‐48 and blaOXA‐181, followed by blaNDM‐5 and blaIMI‐1. Escherichia coli, tar…
View article: Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation
Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation Open
Breast milk oligosaccharides are crucial for neonatal development and health. Yet most milk research focuses on humans, or domesticated mammals that are historically poor in milk oligosaccharide complexity. Here, we perform an exhaustive m…
View article: Applying 3D cultures and high-throughput technologies to study host-pathogen interactions
Applying 3D cultures and high-throughput technologies to study host-pathogen interactions Open
Recent advances in cell culturing and DNA sequencing have dramatically altered the field of human microbiome research. Three-dimensional (3D) cell culture is an important tool in cell biology, in cancer research, and for studying host-micr…
View article: Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE
Genetic adaptation to amoxicillin in Escherichia coli: The limited role of dinB and katE Open
Bacteria can quickly adapt to sub-lethal concentrations of antibiotics. Several stress and DNA repair genes contribute to this adaptation process. However, the pathways leading to adaptation by acquisition of de novo mutations remain poorl…
View article: Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response
Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response Open
This study shows that the SOS response plays a crucial role in resistance development to certain fluoroquinolones, with varying dependencies per drug. The characteristic impact of fluoroquinolones on resistance mechanisms emphasizes the ne…
View article: Limited Effects of Tetracycline and Ciprofloxacin on Soil Bacterial Communities
Limited Effects of Tetracycline and Ciprofloxacin on Soil Bacterial Communities Open
View article: Adaptation of Escherichia coli to ciprofloxacin and enrofloxacin: Differential proteomics of the SOS response and RecA-independent mechanisms
Adaptation of Escherichia coli to ciprofloxacin and enrofloxacin: Differential proteomics of the SOS response and RecA-independent mechanisms Open
The results demonstrate that the slight structural variation between ciprofloxacin and enrofloxacin leads to unique proteomic adaptations. These findings suggest that even subtle chemical differences can lead to distinct adaptive trajector…
View article: Fish are poor sentinels for surveillance of riverine AMR
Fish are poor sentinels for surveillance of riverine AMR Open
Effective surveillance of antimicrobial resistance (AMR) in the environment is crucial for assessing the human and animal health risk of AMR pollution. Wastewater treatment plants (WWTPs) are one of the main sources of AMR pollutants disch…
View article: Metagenomic assemblies tend to break around antibiotic resistance genes
Metagenomic assemblies tend to break around antibiotic resistance genes Open
Background Assembly of metagenomic samples can provide essential information about the mobility potential and taxonomic origin of antibiotic resistance genes (ARGs) and inform interventions to prevent further spread of resistant bacteria. …
View article: Genetic Adaptation to Amoxicillin in<i>Escherichia coli</i>: The Limited Role of<i>dinB</i>and<i>katE</i>
Genetic Adaptation to Amoxicillin in<i>Escherichia coli</i>: The Limited Role of<i>dinB</i>and<i>katE</i> Open
Bacteria can quickly adapt to sub-lethal concentrations of antibiotics. Several stress and DNA repair genes contribute to this adaptation process. However, the pathways leading to adaptation by acquisition of de novo mutations remain poorl…
View article: Fluoroquinolone-Specific Resistance Trajectories in E. coli and their Dependence on the SOS-Response
Fluoroquinolone-Specific Resistance Trajectories in E. coli and their Dependence on the SOS-Response Open
Background Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge. The SOS response, a DNA repair pathway …
View article: Fluoroquinolone-Specific Resistance Trajectories in<i>E. coli</i>and their Dependence on the SOS-Response
Fluoroquinolone-Specific Resistance Trajectories in<i>E. coli</i>and their Dependence on the SOS-Response Open
Fluoroquinolones are essential for treating bacterial infections in both human and veterinary medicine. This study investigates the mechanisms behind acquired resistance to fluoroquinolones with a specific focus on the SOS response - a cri…
View article: Low coverage of species constrains the use of DNA barcoding to assess mosquito biodiversity
Low coverage of species constrains the use of DNA barcoding to assess mosquito biodiversity Open
Mosquitoes (Culicidae) represent the main vector insects globally, and they also inhabit many of the terrestrial and aquatic habitats of the world. DNA barcoding and metabarcoding are now widely used in both research and routine practices …
View article: Organelles in the ointment: improved detection of cryptic mitochondrial reads resolves many unknown sequences in cross-species microbiome analyses
Organelles in the ointment: improved detection of cryptic mitochondrial reads resolves many unknown sequences in cross-species microbiome analyses Open
The genomes of mitochondria and chloroplasts contain ribosomal RNA (rRNA) genes, reflecting their ancestry as free-living bacteria. These organellar rRNAs are often amplified in microbiome studies of animals and plants. If identified, they…
View article: Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice
Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice Open
Antibiotic resistance is a priority public health problem resulting from eco-evolutionary dynamics within microbial communities and their interaction at a mammalian host interface or geographical scale. The links between mammalian host gen…
View article: <i>Escherichia coli</i> in urban marine sediments: interpreting virulence, biofilm formation, halotolerance, and antibiotic resistance to infer contamination or naturalization
<i>Escherichia coli</i> in urban marine sediments: interpreting virulence, biofilm formation, halotolerance, and antibiotic resistance to infer contamination or naturalization Open
Marine sediments have been suggested as a reservoir for pathogenic bacteria, including Escherichia coli. The origins, and properties promoting survival of E. coli in marine sediments (including osmotolerance, biofilm formation capacity, an…
View article: Metagenomic assemblies tend to break around antibiotic resistance genes
Metagenomic assemblies tend to break around antibiotic resistance genes Open
Background Assembly of metagenomic samples can provide essential information about the mobility potential and taxonomic origin of antibiotic resistance genes (ARGs), and inform interventions to prevent further spread of resistant bacteria.…
View article: Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs?
Towards monitoring of antimicrobial resistance in the environment: For what reasons, how to implement it, and what are the data needs? Open
View article: A global baseline for qPCR-determined antimicrobial resistance gene prevalence across environments
A global baseline for qPCR-determined antimicrobial resistance gene prevalence across environments Open
The environment is an important component in the emergence and transmission of antimicrobial resistance (AMR). Despite that, little effort has been made to monitor AMR outside of clinical and veterinary settings. Partially, this is caused …
View article: Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments
Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments Open
View article: Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes
Latent antibiotic resistance genes are abundant, diverse, and mobile in human, animal, and environmental microbiomes Open
Background Bacterial communities in humans, animals, and the external environment maintain a large collection of antibiotic resistance genes (ARGs). However, few of these ARGs are well-characterized and thus established in existing resista…
View article: Development of Early Life Gut Resistome and Mobilome Across Gestational Ages and Microbiota-Modifying Treatments
Development of Early Life Gut Resistome and Mobilome Across Gestational Ages and Microbiota-Modifying Treatments Open
View article: A Risk Management Framework for Emergence of Novel Antibiotic Resistance Determinants
A Risk Management Framework for Emergence of Novel Antibiotic Resistance Determinants Open
View article: The global groundwater resistome: core antibiotic resistance genes, their dynamics and drivers
The global groundwater resistome: core antibiotic resistance genes, their dynamics and drivers Open
Despite the importance of groundwater as a drinking water resource, currently, no comprehensive picture regarding the global levels of antibiotic resistance genes (ARGs) in groundwater environments exists. Moreover, the biotic and abiotic …