Explanipedia

Impact of thyroid dysfunction on clinical outcome in head and neck cancer: a systematic review and meta-analysis Open

Timothy Skinner, Tina S. Roberts, Johan Opperman, Johan Grobbelaar, Muhammed Ajmal · 2025

Background The influence of thyroid dysfunction on the clinical outcomes of head and neck cancer (HNC) patients remains an area of ongoing investigation, with previous studies yielding variable results. Treatments for HNC, particularly rad…

Solitary fibrous tumour of the parapharyngeal space – a case report Open

Herbert Melariri, Abdiwahab Mukhtar, Simone Labuschagne, E Joseph, N Siyeka , et al. · 2025

We present a case of a female patient with solitary fibrous tumour (SFT) originating in the parapharyngeal space which was successfully resected using an open transoral approach. The patient presented with a worsening airway obstruction, o…

Adenoid Ameloblastoma: A Case Report on this Newly Recognized Under-Treated Odontogenic Tumour Open

Fadi Titinchi, Moegamat Sallies, Johan Opperman · 2025

Introduction Adenoid ameloblastoma (AdAM) is a rare epithelial odontogenic tumour recently included in the 5th World Health Organization classification of head and neck tumours as a separate tumour from conventional ameloblastoma. It prese…

Extranodal NK/T-cell Lymphoma, Nasal Type: Report of a Case and Review of the South African Literature Open

Anneze Odendaal, Amir Afrogheh, Wasim Mahomed, Shaun Adam, Johan Grobbelaar , et al. · 2025

A 76-year-old African female was referred to the Ear, Nose and Throat (ENT) clinic at Tygerberg hospital in Cape Town, South Africa, with history of a progressively enlarging painful right-sided nasal mass with nasal obstruction. Her medic…

The description of diagnosed cases of oral epithelial dysplasia at the Tygerberg Oral Health Centre Open

Nocwaka Charlotte Nkomo, A. Jeftha, Faheema Kimmie‐Dhansay, Johan Opperman · 2025

Oral epithelial dysplasia (OED) is a growth anomaly which occurs due to atypical proliferation, change in the architectural and cytological features of cells of epithelial origin, resulting in the formation of a lesion with disturbed diffe…

Tertiary Treponematosis of the Nasal Cavity – Oral Medicine Case Book Open

Anneze Odendaal, Wasim Mahomed, Johan Opperman, Pawel Schubert, Peter M. Sadow · 2024

Both genital and non-genital treponematoses are overtly similar in pathogenesis, natural history and histologic features. In the head and neck, a relatively small percentage of untreated, infected patients may progress from latency to tert…

Advanced tumour-induced osteomalacia secondary to sinonasal phosphaturic mesenchymal tumour Open

Monica van Wijk, Leon Janse van Rensburg, Bianca D. Berndorfler, Johan Opperman, Johan Grobbelaar , et al. · 2024

Phosphaturic mesenchymal tumours (PMT) are rare, benign lesions and the most common tumour to cause tumour-induced osteomalacia (TIO), a paraneoplastic syndrome. Patients frequently exhibit severe osteomalacia, accompanied by multiple frac…

Surrogate Immunohistochemical Markers of Proliferation and Embryonic Stem Cells in Distinguishing Ameloblastoma from Ameloblastic Carcinoma Open

Liam Robinson, Chané Smit, Marlene B. van Heerden, Haroon Moolla, Amir Afrogheh , et al. · 2024

Correlative imaging and histopathology of a complicated sinonasal teratocarcinosarcoma Open

Tineke van Zyl, Leon Janse van Rensburg, Komeela Naidoo, Marc Merven, Johan Opperman · 2023

The contributed case involves the correlative CT, MRI and histopathology of a sinonasal teratocarcinosarcoma with intracranial involvement.

The Prevalence of Human Papillomavirus–Positive Oropharyngeal Squamous Cell Carcinoma at One of the Largest Tertiary Care Centers in Sub-Saharan Africa Open

Gloria Fremah Dapaah, Jos Hille, William C. Faquin, J Whittaker, C Dittrich , et al. · 2021

Context.— Limited data exist on the prevalence of human papillomavirus (HPV)–positive oropharyngeal squamous cell carcinoma in sub-Saharan Africa. Objective.— To determine the prevalence of HPV-positive oropharyngeal squamous cell carcinom…

Corrigendum: Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases Open

Jaanri Brugman, Gerard de Bruyn, Komeela Naidoo, Marc Merven, Johan Opperman , et al. · 2021

[This corrects the article DOI: 10.4102/sajr.v24i1.1978.].

Not always ‘squame’: The rare entity of follicular dendritic cell sarcoma of the tonsil presenting with cervical nodal metastases Open

Jaanri Brugman, Gerard de Bruyn, Komeela Naidoo, Marc Merven, Johan Opperman , et al. · 2020

Although squamous cell carcinoma accounts for the overwhelming majority of head and neck malignant neoplasms, extranodal follicular dendritic cell sarcoma (FDCS) of the pharyngeal region can have a similar clinical presentation. The histop…

Perforation of the palate - A report of two Syphilitic Gumma cases Open

Fadi Titinchi, Nashreen Behardien, Jean Morkel, Johan Opperman · 2020

Syphilis has recently shown resurgence in its incidence especially in immune-compromised patients. We present two cases of tertiary syphilis in middle-aged males with large perforations in the hard and soft palates, one of which had Human …

A Descriptive Epidemiological Study of Head and Neck cancers at a Major Referral Center in Southern Africa Open

Komeela Naidoo, Hannah Simonds, Abdul Kader Ebrahim, Leon Janse van Rensburg, Marc Merven , et al. · 2020

Background The aim was to describe the profile of Head and Neck Cancers (HNC) at a referral centre in South Africa.Methods Records from January 2015 to December 2017 were reviewed.Variables analysed were site, histologic type, age, sex, HI…

Oral Medicine Case Book: An intra-oral solitary Schwannoma of the lower lip, a rare diagnosis Open

Gadidja Abrahams, M.T. Peck, Lawrence Stephen, Johan Opperman · 2019

An intra-oral solitary Schwannoma of the

An Endotracheal Plasmablastic Lymphoma Open

Eva M.T. Bots, Johan Opperman, Fatima Bassa, Coenraad F.N. Koegelenberg · 2019

We describe an exceptionally rare case of a male patient with newly diagnosed advanced human immunodeficiency virus (HIV) infection, who presented with a plasmablastic lymphoma involving the right maxillary alveolar ridge with associated c…

https://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0011-85162019000900006&lng=en&nrm=iso&tlng=en Open

F Opondo, Shoayeb Shaik, Johan Opperman, Nortjé Cj · 2019

The glandular odontogenic cyst (GOC) remains a rare entity. It was initially named "sialo-odontogenic cyst" by Padayachee and Van Wyk in 1987 when they reported the first two cases. Thereafter the term glandular odontogenic cyst was sugges…

Giant maxillary gingival fibromatosis Open

KA Stephenson, Gerhard Johan Klopper, Johan Opperman, Claudio Favara · 2016

We present a case of both unusual pathology and severity – giant maxillary gingival fibromatosis – and discuss the disease and its management, accompanied by clinical imaging. This represents an overlap between maxillofacial and oral surge…

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