Johann F. Osma
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View article: A mathematical phase field model predicts superparamagnetic nanoparticle accelerated fusion of HeLa spheroids for field guided biofabrication
A mathematical phase field model predicts superparamagnetic nanoparticle accelerated fusion of HeLa spheroids for field guided biofabrication Open
In vitro tissue models are crucial for regenerative medicine, drug discovery, and the reduction of animal testing. 3D bioprinting, particularly when utilizing magnetic manipulation of cell spheroids, provides precise control over tissue ar…
View article: Iot-Enabled Automated Microfluidic System for the Functionalizing of Enzymatic Biosensors
Iot-Enabled Automated Microfluidic System for the Functionalizing of Enzymatic Biosensors Open
View article: Portable Miniaturized IoT-Enabled Point-of-Care Device for Electrochemical Sensing of Zopiclone in Cocktails
Portable Miniaturized IoT-Enabled Point-of-Care Device for Electrochemical Sensing of Zopiclone in Cocktails Open
This study proposes a portable and IoT-based electrochemical point-of-care sensing device for detecting zopiclone in cocktails. The system utilizes an electrochemical laccase biosensor and a potentiostat, offering a low-cost and portable d…
View article: Enhancing Magnetic Micro- and Nanoparticle Separation with a Cost-Effective Microfluidic Device Fabricated by Laser Ablation of PMMA
Enhancing Magnetic Micro- and Nanoparticle Separation with a Cost-Effective Microfluidic Device Fabricated by Laser Ablation of PMMA Open
Superparamagnetic iron oxide micro- and nanoparticles have significant applications in biomedical and chemical engineering. This study presents the development and evaluation of a novel low-cost microfluidic device for the purification and…
View article: Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA
Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA Open
Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broa…
View article: Impact of Nanoparticle Additions on Life Cycle Assessment (LCA) of Ceramic Tiles Production
Impact of Nanoparticle Additions on Life Cycle Assessment (LCA) of Ceramic Tiles Production Open
The ceramic tile industry, with significant energy and material demands in its manufacturing processes, has employed technological innovations in energy efficiency, advanced equipment and tile thickness reduction to address these challenge…
View article: Multifunctional Eco-Friendly Adsorbent Cryogels Based on Xylan Derived from Coffee Residues
Multifunctional Eco-Friendly Adsorbent Cryogels Based on Xylan Derived from Coffee Residues Open
Agricultural and animal farming practices contribute significantly to greenhouse gas (GHG) emissions such as NH3, CH4, CO2, and NOx, causing local environmental concerns involving health risks and water/air pollution. A growing need to cap…
View article: Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation
Specific nanoprobe design for MRI: Targeting laminin in the blood-brain barrier to follow alteration due to neuroinflammation Open
Chronic neuroinflammation is characterized by increased blood-brain barrier (BBB) permeability, leading to molecular changes in the central nervous system that can be explored with biomarkers of active neuroinflammatory processes. Magnetic…
View article: Embracing Sustainability in the Industry: A Study of Environmental, Economic, and Exergetic Performances in Large-Scale Production of Magnetite Nanoparticles
Embracing Sustainability in the Industry: A Study of Environmental, Economic, and Exergetic Performances in Large-Scale Production of Magnetite Nanoparticles Open
Magnetite nanoparticles (MNPs), with their distinct properties and controllability by using magnetic fields, have secured a central position in various industrial applications. Nevertheless, the surging demand for MNPs necessitates a metic…
View article: Low-cost inertial microfluidic device for microparticle separation: A laser-Ablated PMMA lab-on-a-chip approach without a cleanroom
Low-cost inertial microfluidic device for microparticle separation: A laser-Ablated PMMA lab-on-a-chip approach without a cleanroom Open
View article: Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices
Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices Open
Microfluidics is an interdisciplinary field that encompasses both science and engineering, which aims to design and fabricate devices capable of manipulating extremely low volumes of fluids on a microscale level. The central objective of m…
View article: Life Cycle Assessment of Magnetite Production Using Microfluidic Devices: Moving from the Laboratory to Industrial Scale
Life Cycle Assessment of Magnetite Production Using Microfluidic Devices: Moving from the Laboratory to Industrial Scale Open
International audience
View article: Comparación de dos tecnologías verdes para el control del crecimiento de Staphylococcus aureus resistente a la meticilina
Comparación de dos tecnologías verdes para el control del crecimiento de Staphylococcus aureus resistente a la meticilina Open
Introducción. El Staphylococcus aureus resistente a la meticilina (MRSA) es una bacteria patógena que según la Organización Mundial de la Salud (OMS) debería incluirse en la lista de patógenos prioritarios frente a los que se deberían desa…
View article: Life Cycle Assessment of Functionalized Bionanocompounds with Ice Nucleation Protein for Freezing Applications
Life Cycle Assessment of Functionalized Bionanocompounds with Ice Nucleation Protein for Freezing Applications Open
The objective of this study was to assess the effectiveness of functionalized bionanocompounds with ice nucleation protein (INP) as a novel approach for freezing applications in terms of how much energy is used during each step of freezing…
View article: Low Toxicity of Magnetite-Based Modified Bionanocomposites Used for Wastewater Treatment: Evaluation in a Zebrafish Animal Model
Low Toxicity of Magnetite-Based Modified Bionanocomposites Used for Wastewater Treatment: Evaluation in a Zebrafish Animal Model Open
View article: Study of Spheroids Fusion via Multiphysics Simulations: Feasibility of Applying Permanent Magnetic Field Gradients
Study of Spheroids Fusion via Multiphysics Simulations: Feasibility of Applying Permanent Magnetic Field Gradients Open
Cell spheroids represent a scaffold-free route to form cell aggregates through maximizing cell-cell interactions. Spheroids have gained significant attention for the engineering of multilayer tissues as they offer a closer resemblance of p…
View article: Modeling and Simulation of Magnetoliposome Formation by Encapsulation of Core-Shell, Magnetite-Chitosan Nanoparticles in Liposomes Enabled by a Low-Cost Microfluidic System
Modeling and Simulation of Magnetoliposome Formation by Encapsulation of Core-Shell, Magnetite-Chitosan Nanoparticles in Liposomes Enabled by a Low-Cost Microfluidic System Open
Research in nanostructured materials has led to the development of different applications of relevance in the fields of medicine and biomedical engineering. In this regard, the field of drug delivery has probably benefited the most due to …
View article: Magnetic Torus Microreactor as a Novel Device for Sample Treatment via Solid-Phase Microextraction Coupled to Graphite Furnace Atomic Absorption Spectroscopy: A Route for Arsenic Pre-Concentration
Magnetic Torus Microreactor as a Novel Device for Sample Treatment via Solid-Phase Microextraction Coupled to Graphite Furnace Atomic Absorption Spectroscopy: A Route for Arsenic Pre-Concentration Open
This work studied the feasibility of using a novel microreactor based on torus geometry to carry out a sample pretreatment before its analysis by graphite furnace atomic absorption. The miniaturized retention of total arsenic was performed…
View article: CFD Analysis and Life Cycle Assessment of Continuous Synthesis of Magnetite Nanoparticles Using 2D and 3D Micromixers
CFD Analysis and Life Cycle Assessment of Continuous Synthesis of Magnetite Nanoparticles Using 2D and 3D Micromixers Open
Magnetite nanoparticles (MNPs) have attracted basic and applied research due to their immense potential to enable applications in fields as varied as drug delivery and bioremediation. Conventional synthesis schemes led to wide particle siz…
View article: Novel Magnetic Polymeric Filters with Laccase-Based Nanoparticles for Improving Congo Red Decolorization in Bioreactors
Novel Magnetic Polymeric Filters with Laccase-Based Nanoparticles for Improving Congo Red Decolorization in Bioreactors Open
In this work, five different magnetic biofilters, containing magnetic nanoparticles (142 nm), immobilized laccase on nanoparticles (190 nm) and permanent magnetic elements, such as neodymium magnets and metallic meshes, were designed, manu…
View article: Blood-Vessel-Inspired Hierarchical Trilayer Scaffolds: PCL/Gelatin-Driven Protein Adsorption and Cellular Interaction
Blood-Vessel-Inspired Hierarchical Trilayer Scaffolds: PCL/Gelatin-Driven Protein Adsorption and Cellular Interaction Open
Fabrication of scaffolds with hierarchical structures exhibiting the blood vessel topological and biochemical features of the native extracellular matrix that maintain long-term patency remains a major challenge. Within this context, scaff…
View article: Treatment of Wastewater, Phenols and Dyes Using Novel Magnetic Torus Microreactors and Laccase Immobilized on Magnetite Nanoparticles
Treatment of Wastewater, Phenols and Dyes Using Novel Magnetic Torus Microreactors and Laccase Immobilized on Magnetite Nanoparticles Open
In this work, the design, manufacture, and testing of three different magnetic microreactors based on torus geometries (i.e., one-loop, two-horizontal-loop, and two-vertical-loop) is explored to increase the enzyme-based transformation of …
View article: Continuous Nanoprecipitation of Polycaprolactone in Additively Manufactured Micromixers
Continuous Nanoprecipitation of Polycaprolactone in Additively Manufactured Micromixers Open
The polymeric ouzo effect is an energy-efficient and robust method to create nanoparticles with biologically degradable polymers. Usually, a discontinuous or semi-continuous process is employed due to its low technical effort and the fact …
View article: Comparison of Acetaminophen Degradation by Laccases Immobilized by Two Different Methods via a Continuous Flow Microreactor Process Scheme
Comparison of Acetaminophen Degradation by Laccases Immobilized by Two Different Methods via a Continuous Flow Microreactor Process Scheme Open
The presence of micropollutants in wastewater is one of the most significant environmental challenges. Particularly, pollutants such as pharmaceutical residues present high stability and resistance to conventional physicochemical and biolo…
View article: Toxicity of Modified Magnetite-Based Nanocomposites Used for Wastewater Treatment and Evaluated on Zebrafish (Danio rerio) Model
Toxicity of Modified Magnetite-Based Nanocomposites Used for Wastewater Treatment and Evaluated on Zebrafish (Danio rerio) Model Open
Magnetite-based nanocomposites are used for biomedical, industrial, and environmental applications. In this study, we evaluated their effects on survival, malformation, reproduction, and behavior in a zebrafish animal model. Nanoparticles …
View article: Microfluidic Synthesis and Purification of Magnetoliposomes for Potential Applications in the Gastrointestinal Delivery of Difficult-to-Transport Drugs
Microfluidic Synthesis and Purification of Magnetoliposomes for Potential Applications in the Gastrointestinal Delivery of Difficult-to-Transport Drugs Open
Magnetite nanoparticles (MNPs) have gained significant attention in several applications for drug delivery. However, there are some issues related to cell penetration, especially in the transport of cargoes that show limited membrane passi…
View article: Wearable and fully printed microfluidic nanosensor for sweat rate, conductivity, and copper detection with healthcare applications
Wearable and fully printed microfluidic nanosensor for sweat rate, conductivity, and copper detection with healthcare applications Open
View article: Low-Cost Platform for Multiplexed Electrochemical Melting Curve Analysis
Low-Cost Platform for Multiplexed Electrochemical Melting Curve Analysis Open
Detection and identification of single nucleotide polymorphisms (SNPs) have garnered increasing interest in the past decade, finding potential application in detection of antibiotic resistance, advanced forensic science, as well as clinica…
View article: Design and Manufacture of a Low-Cost Microfluidic System for the Synthesis of Giant Liposomes for the Encapsulation of Yeast Homologues: Applications in the Screening of Membrane-Active Peptide Libraries
Design and Manufacture of a Low-Cost Microfluidic System for the Synthesis of Giant Liposomes for the Encapsulation of Yeast Homologues: Applications in the Screening of Membrane-Active Peptide Libraries Open
The discovery of new membrane-active peptides (MAPs) is an area of considerable interest in modern biotechnology considering their ample applicability in several fields ranging from the development of novel delivery vehicles (via cell-pene…
View article: Design, Simulation, and Fabrication of a Copper–Chrome-Based Glass Heater Integrated into a PMMA Microfluidic System
Design, Simulation, and Fabrication of a Copper–Chrome-Based Glass Heater Integrated into a PMMA Microfluidic System Open
In this paper, the development of a copper–chrome-based glass microheater and its integration into a Polymethylmethacrylate (PMMA) microfluidic system are presented. The process highlights the importance of an appropriate characterization,…