Johann Gassenhuber
YOU?
Author Swipe
View article: First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of <scp>TNFR1</scp> Signaling in Healthy Participants
First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of <span>TNFR1</span> Signaling in Healthy Participants Open
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor …
View article: Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits Open
View article: The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy
The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy Open
View article: Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials Open
View article: Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist Open
View article: Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study Open
Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 mo…
View article: A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity
A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity Open
Context Glucagon is produced and released from the pancreatic alpha-cell to regulate glucose levels during periods of fasting. The main target for glucagon action is the liver, where it activates gluconeogenesis and glycogen breakdown; how…
View article: Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study
Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study Open
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research …
View article: Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration Open
View article: Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by <i>SLC29A4</i> ) and Organic Cation Transporter 1 (OCT1) (Encoded by <i>SLC22A1</i> ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study
Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by <i>SLC29A4</i> ) and Organic Cation Transporter 1 (OCT1) (Encoded by <i>SLC22A1</i> ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study Open
OBJECTIVE Gastrointestinal adverse effects occur in 20–30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5–10% of the cases. Gastrointestinal intolerance may reflect localized high concentratio…
View article: Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals
Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals Open
Targeted sequencing of genes linked with monogenic diabetes can identify disease-relevant mutations in individuals diagnosed with type 2 diabetes not suspected of having monogenic forms of the disease. Our data suggests that GCK-MODY frequ…
View article: Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels Open
View article: MOESM2 of Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels
MOESM2 of Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels Open
Additional file 2. Overview of proteins that were identified and quantified in at least three of the four replicate experiments.